sterol regulatory element binding proteins
Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress
... (10). Sterol regulatory element binding proteins (SREBPs) are endoplasmic reticulum (ER) membrane-bound transcription factors that activate genes encoding the enzymes that regulate the ...
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Sterol Regulatory Element Binding Proteins; Central Metabolic Regulators of Natural Killer Cells
... In many cell types, the activity of sterol regulatory element binding proteins (SREBP) is induced downstream of mTORC1 activation (Porstmann et al. 2008). SREBP transcription factors ...
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Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
... To date, in-depth characterizations of fungal SREBPs have been performed for S. pombe, C. neoformans, and A. fumigatus. However, many fungal species contain putative SREBPs and components of the SREBP pathway, including ...
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Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1
... nisms. Sterol regulatory element binding proteins (SREBPs) are the principal regulators to maintain the proper levels of intracel- lular lipids (15); their biology and means of ...
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Effects of sterol regulatory element-binding protein (SREBP) in chickens
... Sterol regulatory element binding proteins (SREBP) are basic helix-loop-helix-leucine zipper (bHLH-Zip) tran- scription factors that play an important role in control- ling genes ...
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Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance in Cryptococcus neoformans
... other proteins functionally related to the mutated protein might compensate for the defects in the ...other proteins of ...unidentified proteins may functionally substitute for Kap123 and reduce the ...
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Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue
... and sterol regulatory element binding protein 1c (SREBP-1c) at 60 kg and 100 kg; however, the mRNA level and enzyme activity of FAS were increased at 30 ...acid binding proteins ...
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Plastic Surgery Update on the Biology of Fat Cells and Adipose Derived Stem Cells for Fat Grafting
... enhancer- binding proteins α , β , δ ); PPAR γ (Transcriptional peroxisome proliferator-activated receptor gamma, a central regulator of differentiation); ADD1/SREEP1c (Transcription factor adipocyte ...
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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element binding protein 2
... encoded proteins terminate at a point be- tween the bHLH-Zip domain and the membrane-attachment ...Such proteins are never membrane bound, and they enter the nucleus directly without a requirement for ...
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An in silico study on the interaction between RU486, a glucocorticoid antagonist and some regulatory proteins of lipid metabolism
... lipogenic proteins namely hairy enhancer of split -1 (HES-1), peroxisome proliferator- activated receptor γ (PPARγ), sterol regulatory element-binding protein 1c (SREBP-1c), cluster ...
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Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
... Glycolysis provides the biosynthetic precursors that are essential for the synthesis of proteins, nucleic acids and lipids (Hume et al., 1978). Pro- inflammatory immune cells have the ability to engage in robust ...
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Sterol Regulatory Element-Binding Protein 2 Couples HIV-1 Transcription to Cholesterol Homeostasis and T Cell Activation
... HIV-infected individuals develop a series of metabolic dis- orders, including lipodystrophy and dyslipidemia (12). Mi- croarray and proteomic studies have revealed that HIV-1 in- fection of CD4 ⫹ T cells results in ...
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
... We found that oleic acid was the most abundant free fatty acid and constitutes approximately 30% of the total pool of free fatty acids in control cells (Additional file 6: Table S2). Interestingly, SREBP depletion caused ...
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FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
... Forkhead box class O (FoxO) is a nuclear protein sub- family that includes four homologous proteins in mam- mals: FoxO1, FoxO3, FoxO4 and FoxO6. These proteins share a highly conserved Forkhead DNA ...
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AMPK: A POTENT TARGET FOR TREATING OBESITY
... AMPK mediates a number of physiological functions like carbohydrate and lipid metabolism, growth and differentiation, ion transport and blood flow, appetite regulation etc by regulating the genes (shown in ...
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Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death
... Our results are in accordance with a previous study in which the SREBF-2 C allele in combination with the SCAP G allele was associated with an increased risk of MI in males [17]. Our results extend the existing data, ...
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Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity
... bHLH proteins, also known as E proteins [124] which form homo- or hetero-dimers and bind to specific DNA sequences ...[125]. Sterol regulatory element-binding protein 1 (SREBP1) ...
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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
... encoding proteins involved in cholesterol uptake (LDL receptor) and synthesis (HMG CoA synthase, HMG CoA reductase, and squalene synthase); and 9–16-fold elevations in mRNAs en- coding enzymes of fatty acid ...
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Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells
... lipogenic proteins: ACC (acetyl-CoA carboxylase), FASN (fatty acid synthase) and SREBP1c (sterol regulatory element binding protein-1c), whereas there is no modification in DU145 and ...
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Sterol regulatory element binding protein 1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
... [27]. Schernhammer ES, Holly JM, Hunter DJ, Pollak MN, Hankinson SE. Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health ...
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