sterol regulatory element binding proteins 2
Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress
... the histological grade of steatosis (28). The molecular mecha- nism(s) underlying the altered cholesterol/lipid homeostasis in response to HCV gene expression has not been characterized. In the present study, we ...
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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
... encoding proteins involved in cholesterol uptake (LDL receptor) and synthesis (HMG CoA synthase, HMG CoA reductase, and squalene synthase); and 9–16-fold elevations in mRNAs en- coding enzymes of fatty acid ...
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AMPK: A POTENT TARGET FOR TREATING OBESITY
... responsive element binding ...kinase 2. SD: succinate dehydrogenase. SREBP-1: sterol regulatory element binding ...
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Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1
... cellular sterol level and requires expression of viral ...cellular sterol levels; cleavage is enhanced by sterol depletion and inhibited by sterol supplement (1, ...by sterol levels in ...
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Sterol Regulatory Element-Binding Protein 2 Couples HIV-1 Transcription to Cholesterol Homeostasis and T Cell Activation
... HIV-infected individuals develop a series of metabolic dis- orders, including lipodystrophy and dyslipidemia (12). Mi- croarray and proteomic studies have revealed that HIV-1 in- fection of CD4 ⫹ T cells results in ...
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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein 1 in human and mouse organs and cultured cells
... two proteins can form heterodimers, this does not appear neces- sary for their function ...both proteins is enhanced by sterol depletion and inhibited by sterol supplementation (1, ...NH ...
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
... including proteins and ...and 2 (S6K1 and S6K2) and eukaryotic translation initi- ation factor 4E binding protein 1 ...the sterol regulatory element binding pro- teins ...
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Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid
... is a multifunctional enzyme produced by many tissues, including adipose tissue, cardiac and skeletal muscle, islets, and macrophages, but LPL is in normally not made in the adult liver [17]. Sterol ...
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Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death
... Our results are in accordance with a previous study in which the SREBF-2 C allele in combination with the SCAP G allele was associated with an increased risk of MI in males [17]. Our results extend the existing ...
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Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
... a sterol-independent mechanism for the reg- ulation of Sre1 ...the 2-oxo- glutarate Fe(II) dioxygenase domain-containing protein Ofd1 (20, ...the 2-oxoglutarate Fe(II) dioxygenase prolyl hydroxylase ...
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Sterol Regulatory Element Binding Proteins; Central Metabolic Regulators of Natural Killer Cells
... inhibitors 2-deoxyglucose (2DG) and oligomycin that limit but do not completely inhibit glycolysis and OxPhos, respectively, are found to inhibit the production of IFNg and the expression of granzyme b in both ...
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FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
... SREBP1c; 2) adenovirus or plasmid mediated overexpression of FoxO3 resulted in increased expression of SREBP1c; 3) SREBP1c expression was increased in the livers of Ad-FoxO3-treated mice; and 4) the constitutively ...
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Sterol regulatory element binding protein 1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
... SREBP is a gene that regulates lipogenesis. Its expression is regulated by the insulin and sterol levels in the cell. In mammalian cells, three isoforms of SREBP have been identified, namely SREBP1a, SREBP1c and ...
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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element binding protein 2
... The SREBP-2 transgene construct was injected into mouse eggs, and we derived two independent lines of transgenic mice, designated A and B. To increase expression, mice from line B were bred to homozygosity for the ...
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Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue
... and sterol regulatory element binding protein 1c (SREBP-1c) at 60 kg and 100 kg; however, the mRNA level and enzyme activity of FAS were increased at 30 ...acid binding proteins ...
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Host Factors in Enterovirus 71 Replication
... Figure 2 summarizes the roles of host factors described above for EV71 ...of proteins controlling IRES-dependent translation initiation is dependent on their subcellular localization ...cellular ...
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Tissue-specific and ubiquitous factors binding next to the glucocorticoid receptor modulate transcription from the mouse mammary tumor virus promoter.
... In the absence of a sufficiently differentiated transfectable liver cell line which could prevent MMTV transcription, it is not yet possible to test our hypothesis that the protein(s) bind- ing to the DRa site may ...
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Sterol Binding by the Tombusviral Replication Proteins Is Essential for Replication in Yeast and Plants
... require sterol-rich microdomains to facilitate the efficient sequestration of viral replication proteins and co-opted host factors, while other host components should be excluded from ...replication ...
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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
... In the work presented here, insulin regulates ADD1/ SREBP1 on at least two levels. It increases greatly its expres- sion at the mRNA level and does so at doses of insulin consis- tent with a function through the insulin ...
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Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
... Glycolysis provides the biosynthetic precursors that are essential for the synthesis of proteins, nucleic acids and lipids (Hume et al., 1978). Pro- inflammatory immune cells have the ability to engage in robust ...
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