Sterol Response Element Binding Protein
Les “Liver X receptors” (LXRs) et le métabolisme lipidique dans l’épididyme murin
... Puisque les LXRs sont connus pour reguler I'expression de srebplc et de fas, codant respectivement pour la <<sterol response element binding protein >> et la &l[r] ...
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Sterol Regulatory Element-Binding Protein 2 Couples HIV-1 Transcription to Cholesterol Homeostasis and T Cell Activation
... The results of recent studies on the pathogenesis of AIDS suggest that our findings may have important implications be- yond HIV transcription. Sedaghat et al. have reported that activated CD4 ⫹ T cells from untreated ...
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Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
... transcriptional response revealed a sterol-independent mechanism for the reg- ulation of Sre1 ...domain-containing protein Ofd1 (20, ...transcriptional response under low-oxygen ...nuclear ...
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Conservation of the Sterol Regulatory Element-Binding Protein Pathway and Its Pathobiological Importance in Cryptococcus neoformans
... Sre1 pathway mutants manifest growth defects under low- oxygen conditions. To identify the genes important for C. neo- formans to grow under low-oxygen conditions, we used the ATMT system and generated an insertional ...
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Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
... To accurately characterize the metabolic changes occurring following NK cell activation requires detailed metabolic analyses, which require cell numbers that cannot realistically be generated and isolated from in vivo ...
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Analysis of hepatic gene transcription in mice expressing insulin insensitive GSK3
... insulin response element) that can be regu- lated by several transcription factors such as members of the Forkhead (FOXO) family ...phosphoinositide-dependent protein kinase-1) [16] and ...regulatory ...
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
... unfolded protein response (UPR) is a stress path- way that is activated in response to the accumulation of misfolded proteins in the ER (also referred to as ...general protein translation and ...
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<p>Therapeutic targets of hypercholesterolemia: HMGCR and LDLR</p>
... mitogen-activated protein kinase 1 (MEK1)/ERK-PCSK9 ...cer binding protein (c/EBP), cAMP-responsive element binding protein (CBP) and early growth response gene 1 (Egr1) ...
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Sterol Regulatory Element Binding Proteins; Central Metabolic Regulators of Natural Killer Cells
... 25HC can ligate and activate the liver X receptor (LXR). The LXR is a ligand- activated transcription factor whose ligands include various oxysterol species and intermediates derived from the cholesterol synthesis ...
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Effects of sterol regulatory element-binding protein (SREBP) in chickens
... the binding of acetylcholine to M2 muscarinic receptors localized primarily on atrial ...Acetylcholine binding con- sequences in the dissociation of the heterotrimeric G protein, Ga2, into a12 and bg ...
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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
... in response to fasting and feeding is an important adapta- tion allowing survival of intermittent food ...regulatory element binding protein (SREBP) 1, a basic-helix-loop-helix protein ...
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Protein-protein interactions of transcription factor CREB 1
... polymerase activities (Promega TN T systems) enables coupled transcription- translation from linearized DNA templates with strikingly uniform efficiency between related templates (that is, templates which share common ...
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Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1
... SREBP, sterol regulatory element binding protein; SCAP, SREBP cleavage-activation protein; INSIG-1, insulin-induced gene 1; ER, endoplasmic ...
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<p>Glucocorticoid Receptor α Mediates Roflumilast’s Ability to Restore Dexamethasone Sensitivity in COPD</p>
... Figure 3 Ro fl stimulates GR α promoter activity and induces GR α transcriptional activity. (A) Promoter activity. COPD HBE cells were treated with Ro fl (0.5 or 1 µM) or Veh for 6 h, and then nuclear extracts were ...
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Anxiolytic effects of Formononetin in an inflammatory pain mouse model
... Knowing that inflammation plays a key role in the de- velopment of anxiety [66], the anti-inflammatory effects of FMNT were also explored by monitoring the expres- sions of (i) NF-κB, the first responder to inflammation, ...
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Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid
... is a multifunctional enzyme produced by many tissues, including adipose tissue, cardiac and skeletal muscle, islets, and macrophages, but LPL is in normally not made in the adult liver [17]. Sterol regulatory ...
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Human papillomavirus type 16 E6 protein transcriptionally modulates fibronectin gene expression by induction of protein complexes binding to the cyclic AMP response element.
... a protein whose interaction with members of the AP-1/ATF fam- ily (21), which bind CRE, has been extensively researched (30, 34, ...no response to the expression of E1A, to the coexpression of E6 and E1A, ...
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Sterol regulatory element binding protein 1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
... endometrial Sterol Regulatory Element Binding Protein-1 gene (SREBP1) expression in PCOS and EC endometrium, and to correlate endometrial SREBP1 expression with serum lipid ...
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Dual functions of Insig proteins in cholesterol homeostasis
... structures binding to SREBPs [38,39] and also coat proteins clustering SCAP/SREBP complexes into CopII vesicles that bud from the ER ...of sterol regulation [43,44], and the C terminal extensions can be ...
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Transcriptional regulation of the thyrotropin releasing hormone gene by leptin and melanocortin signaling
... heterologous mammalian cells. Our data demonstrates that the MC4R and ObRb signaling pathways are able specifically to activate the human TRH promoter through distinct cis-acting elements. The MC4R, like the other ...
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