store-operated calcium
The Potential Role of Store-Operated Calcium Entry (SOCE) Pathways in the Pathophysiology of Epilepsy and Migraine-Like Headaches in Patients with Neurocysticercosis
... the store-operated calcium entry (SOCE) pathways are involved in the regulation of the intracellular ionic equilibrium and are determinants of the neuronal excitability ...
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Activation of the Endoplasmic Reticulum Calcium Sensor STIM1 and Store-Operated Calcium Entry by Rotavirus Requires NSP4 Viroporin Activity
... ER calcium stores and activation of plasma membrane (PM) calcium influx channels, ultimately causing a 2- to 4-fold elevation in cytoplasmic ...cytoplasmic calcium is abso- lutely required for virus ...
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FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry
... intracellular calcium concentration and expression of ORAI1 and STIM1 – two key regulatory proteins of store-operated calcium entry ...
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FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma
... Several fibroblast growth factor (FGF) isoforms act to stimulate epithelial- mesenchymal transition (EMT) during cancer progression. FGF4 and FGF7 are two ligands of FGF receptor 2 (FGFR2). Using two lung adenocarcinoma ...
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Systems Modeling of Calcium Homeostasis and Mobilization in Platelets Mediated by Ip3 and Store-Operated Calcium Entry
... mediated calcium regulation was extended to include mechanisms for calcium influx from the extracellular ...cytosolic calcium responses to a transient stimulatory ...platelet calcium signaling ...
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Activation of store operated calcium entry in airway smooth muscle cells: insight from a mathematical model
... to assume that a small fraction of STIM proteins reside in close proximity to the PM, and may thus bind Orai quickly upon store depletion. Hence, a weak SOCE is likely to occur almost instantaneously upon ...
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A key role for STIM1 in store operated calcium channel activation in airway smooth muscle
... 4. Corteling RL, Li S, Giddings J, Westwick J, Poll C, Hall IP: Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue. Am J ...
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Role of Dicer Enzyme in the Regulation of Store Operated Calcium Entry (SOCE) in CD4+ T Cells
... with calcium containing Fluo4 and Fluo3 (Invitrogen, Germany) for 30 minutes in a 37 °C incubator as described earlier ...intracellular calcium levels were measured by flow cytometry analysing 20,000 ...
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Inhibition of store-operated calcium entry in microglia by helminth factors: implications for immune suppression in neurocysticercosis
... in microglia and (2) what are the mechanisms involved in this process. Helminth-induced modulation of microglial activation and regulation of production of inflammatory mediators from these brain cells is poorly ...
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Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling
... on calcium signaling underlying transmission mediated by human M3 muscarinic receptors expressed in Chinese hamster ovary (CHO) ...intracellular calcium concentrations were determined using a fura-2 ...
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RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry
... Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ...
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Excess NO stabilizes the luminal domain of STIM2 in a Cys-specific manner thereby regulating basal calcium homeostasis and store-operated calcium entry
... The luminal region of STIMs (i.e. residing within the ER lumen) contains an ER targeting signal peptide (SP) sequence, an N-terminal region that is not conserved among phylogeny as well as canonical and non-canonical ...
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Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability
... calpain-dependent cyclin A proteolysis has been implicated in centrosome overduplication in HBV- mediated hepatocarcinogenesis [26]. We measured the number of centrosomes in hepatocytes with or without LHBS. Compared ...
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Activation of ERK1/2 by Store-Operated Calcium Entry in Rat Parotid Acinar Cells
... operated Ca 2+ entry (SOCE). Ca 2+ entry is also increased in a store-independent manner by arachidonate-regulated Ca 2+ (ARC) channels. Using rat parotid salivary gland cells, we examined multiple pathways ...
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Original Article Upregulated TRPC5 plays an important role in development of nasal polyps by activating eosinophilic inflammation and NF-κB signaling pathways
... TRPC channels are recognized as one of the store-operated calcium channels involved in regulating functions of different mammalian cell types [7-11, 24]. Recently, TRPC channels have been found to ...
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Role of Inositol 1, 4, 5-Triphosphate on Heart Rate in Isolated Heart Models of Wistar Rats
... of calcium and refill the ...as Store operated Calcium Entry (SOCE)(Putney, 1990, ...highly calcium selective, inward rectifying current and not voltage selective (Hoth and Penner, ...
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Orai1: CRACing the Th17 response in AKI
... A strong Th17 inflammatory response aggravates ischemia reperfusion– induced (IR-induced) acute kidney injury (AKI), tissue fibrosis, and AKI-to–chronic kidney disease (CKD) progression. However, the underlying ...
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S-Nitrosylation Suppresses Stromal Interaction Molecule-1 Activation and Ameliorates Cardiomyocyte Hypertrophy
... stromal interaction molecule-1, nitric oxide synthase, S -nitrosylation, phenylephrine, cardiomyocyte, hypertrophy, store-operated calcium entry, nuclear magnetic resonance spectrosco[r] ...
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The 2β Insert Perturbs Folding, Stability and Hydrophobic Exposure of Stromal Interaction Molecules
... Stromal interaction molecule-1 (STIM1), stromal interaction molecule-2 (STIM2), store- operated calcium entry (SOCE), calcium, alterative splicing, coiled-coil domains, stability oligom[r] ...
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Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells
... observations suggest some degree of cooperation among the various signaling events activated by vasoconstrictors via G-protein coupled receptors. In canine pulmonary vein smooth muscle cells, activation or inhibition of ...
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