Store-operated calcium entry
FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma
... Several fibroblast growth factor (FGF) isoforms act to stimulate epithelial- mesenchymal transition (EMT) during cancer progression. FGF4 and FGF7 are two ligands of FGF receptor 2 (FGFR2). Using two lung adenocarcinoma ...
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FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry
... intracellular calcium concentration and expression of ORAI1 and STIM1 – two key regulatory proteins of store-operated calcium entry ...
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The Potential Role of Store-Operated Calcium Entry (SOCE) Pathways in the Pathophysiology of Epilepsy and Migraine-Like Headaches in Patients with Neurocysticercosis
... the store-operated calcium entry (SOCE) pathways are involved in the regulation of the intracellular ionic equilibrium and are determinants of the neuronal excitability ...
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Systems Modeling of Calcium Homeostasis and Mobilization in Platelets Mediated by Ip3 and Store-Operated Calcium Entry
... mediated calcium regulation was extended to include mechanisms for calcium influx from the extracellular ...cytosolic calcium responses to a transient stimulatory ...platelet calcium signaling ...
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Activation of the Endoplasmic Reticulum Calcium Sensor STIM1 and Store-Operated Calcium Entry by Rotavirus Requires NSP4 Viroporin Activity
... ER calcium stores and activation of plasma membrane (PM) calcium influx channels, ultimately causing a 2- to 4-fold elevation in cytoplasmic ...cytoplasmic calcium is abso- lutely required for virus ...
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Activation of store operated calcium entry in airway smooth muscle cells: insight from a mathematical model
... 10. Moynihan B, Tolloczko B, Michoud MC, Tamaoka M, Ferraro P, et al. (2008) MAP kinases mediate interleukin-13 effects on calcium signaling in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol ...
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Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling
... Honokiol’s effect on SOCE was selective insofar as honokiol inhibited SOCE at lower concentrations than it affected ER calcium release induced by either IP3 re- ceptor activation or thapsigargin inhibition of ...
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Role of Dicer Enzyme in the Regulation of Store Operated Calcium Entry (SOCE) in CD4+ T Cells
... with calcium containing Fluo4 and Fluo3 (Invitrogen, Germany) for 30 minutes in a 37 °C incubator as described earlier ...intracellular calcium levels were measured by flow cytometry analysing 20,000 ...
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Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability
... calpain-dependent cyclin A proteolysis has been implicated in centrosome overduplication in HBV- mediated hepatocarcinogenesis [26]. We measured the number of centrosomes in hepatocytes with or without LHBS. Compared ...
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Excess NO stabilizes the luminal domain of STIM2 in a Cys-specific manner thereby regulating basal calcium homeostasis and store-operated calcium entry
... The luminal region of STIMs (i.e. residing within the ER lumen) contains an ER targeting signal peptide (SP) sequence, an N-terminal region that is not conserved among phylogeny as well as canonical and non-canonical ...
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Inhibition of store-operated calcium entry in microglia by helminth factors: implications for immune suppression in neurocysticercosis
... to store-operated Ca 2+ entry (SOCE) has been implicated in induction of downstream signaling, we tested the inhibitory effect of HSFs on agonist-induced Ca 2+ influx and specific Ca 2+ channel ...ER ...
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RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry
... Indeed, RPGR and RPGRIP1 have been reported to co-localize in the connecting cilia of photoreceptors and centrosomes/basal bodies of differentiating cells [8, 18, 23, 24]. RPGRIP1L is also localized to the basal bodies ...
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Activation of ERK1/2 by Store-Operated Calcium Entry in Rat Parotid Acinar Cells
... the entry of Ca 2+ via SOCE ...the entry of Ca 2+ into cells in which Ca 2+ stores were first depleted by TG (as in Figure 8) was not affected when ERK1/2 activation was blocked by exposing cells to MEK ...
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Resveratrol reduces store-operated Ca2+ entry and enhances the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats model via targeting ORAI1–STIM1 complex
... [5]. Store operated calcium entry (SOCE) is an intracellular biolog- ical process, in which a specific group of calcium chan- nels mediate extracellular calcium influx for ...
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Role of Inositol 1, 4, 5-Triphosphate on Heart Rate in Isolated Heart Models of Wistar Rats
... of calcium and refill the ...as Store operated Calcium Entry (SOCE)(Putney, 1990, ...highly calcium selective, inward rectifying current and not voltage selective (Hoth and ...
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S-Nitrosylation Suppresses Stromal Interaction Molecule-1 Activation and Ameliorates Cardiomyocyte Hypertrophy
... stromal interaction molecule-1, nitric oxide synthase, S -nitrosylation, phenylephrine, cardiomyocyte, hypertrophy, store-operated calcium entry, nuclear magnetic resonance spectrosco[r] ...
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The 2β Insert Perturbs Folding, Stability and Hydrophobic Exposure of Stromal Interaction Molecules
... Stromal interaction molecule-1 (STIM1), stromal interaction molecule-2 (STIM2), store- operated calcium entry (SOCE), calcium, alterative splicing, coiled-coil domains, stability oligom[r] ...
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Photoactivated fullerene C(60) induces store-operated Ca(2+) entry and cytochrome c release in Jurkat cells
... of calcium homeostasis: underfilling of ER calcium pool and reducing of SOCE in cancer cells is directed at prevention of Ca 2+ -dependent way of apoptosis induction [1, ...
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A key role for STIM1 in store operated calcium channel activation in airway smooth muscle
... both store depletion and agonist activation by ...induced calcium entry in Drosophilia S2 cells, Jurkat T cells [5] and Hela cells [6] with the latter study also impli- cating a role for ...of ...
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Activation of store – operated Ca(2+) entry in cisplatin resistant leukemic cells after treatment with photoexcited fullerene C(60) and cisplatin
... 9. Gélébart P, Kovács T, Brouland JP, van Gorp R, Grossmann J, Rivard N, Panis Y, Martin V, Bredoux R, Enouf J, Papp B. Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of ...
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