Stress-induced apoptosis
ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription
... oxidative stress, including hypoxia and altered metabolism, ZNF32 performs an important function in the protection of cells from oxidative stress-induced apoptosis, and this function enables ...
20
(+) Catechin protects dermal fibroblasts against oxidative stress induced apoptosis
... oxidative stress-induced apoptosis in fibroblasts, we focused on the effects of (+)-catechin on the phosphorylation of p38 and JNK, both of which are key molecules for oxidative ...
7
ILK modulates stress-induced apoptosis in epidermal keratinocytes
... Integrin-linked kinase (ILK) is a ubiquitous scaffold protein that mediates cellular responses to integrin stimulation by extracellular matrix proteins. Mice with inactivation of the Ilk gene in squamous epithelia ...
142
Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway
... To investigate the mechanistic basis for the effects of ketamine, TUNEL staining was used to examine neural cells in injured brain tissue. TUNEL-positive cells were detected at a low frequency in the brains of mice in ...
9
Bufalin Induces the Interplay between Apoptosis and Autophagy in Glioma Cells through Endoplasmic Reticulum Stress
... ER stress has not been reached, in part because the broad range of intracellular effects varies in different cell ...bufalin induced UPR in glioma cells: increased GRP78 and GRP94, cleavage of ATF6, ...
13
The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration
... genes induced by tunicamycin was maximally decreased by both mometasone and GRT10 (Figure ...ER stress, which was efficiently diminished both at RNA and protein levels by mometasone and GRT10 (Figure 4B), ...
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Engineered nanoparticles induce cell apoptosis: potential for cancer therapy
... status. Apoptosis-related genes (bax and chop) and proteins (caspase 3/9/12 and JNK) were seen to be highly ...oxidative stress promoted by nano-ZnO ...oxidative stress and ER stress ...
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Original Article Effect of HSP70 on cardiomyocyte apoptosis induced by endoplasmic reticulum stress
... ER stress. To study the molecular mechanism of HSP70 regulated ER stress-induced apoptosis, flow cytometry was used to detect apoptosis rate of neonatal rat myocardial cells, western ...
9
Original Article Hydrogen sulfide preconditioning protects against myocardial ischemia/reperfusion injury in rats through inhibition of endo/sarcoplasmic reticulum stress
... rats induced by myocardial ...ER/SR stress [5, 7, ...ER/SR stress-induced ...ER/SR stress and is recognized as an important mediator of ER/SR stress ...ER/SR stress ...
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Regulation of apoptosis in postmitotic cells
... ER stress has been implicated as the underlying cause of the death of many neurodegenerative disorders (Lindholm et ...ER stress induced apoptosis has been the subject of much ...ER ...
193
Reactive Oxygen Species Related Noncoding RNAs as Regulators of Cardiovascular Diseases
... cell apoptosis and ROS production in the rat model ...cell apoptosis by activating cleaved-caspase ...the apoptosis of cardiomyocytes mediated by caspase3 through targeting ...inhibited ...
8
Augmenting autophagy for prognosis based intervention of COPD-pathophysiology
... aggresome-bodies (insoluble protein fraction) in alveolar epithelial or structural cells and lungs (human and murine) [10, 11, 17, 18, 20, 22, 25, 29, 30]. Although acute CS exposure initiates modest changes in autophagy ...
8
In vitro cytotoxicity and induction of apoptosis by silica nanoparticles in human HepG2 hepatoma cells
... oxidative stress and apoptosis were induced after exposure to 7–20 nm silica ...oxidative stress mediated by reactive oxygen species may be involved in apoptosis induced by ...
13
PCV2 replication promoted by oxidative stress is dependent on the regulation of autophagy on apoptosis
... Autophagy is an evolutionarily conserved catabolic process involved in the degradation and recycling of cytoplasmic components. It plays an essential role in nor- mal development and responds to changing environmen- tal ...
11
Methacryloxylethyl Cetyl Ammonium Chloride Induces DNA Damage and Apoptosis in Human Dental Pulp Cells via Generation of Oxidative Stress
... DMAE-CB induced oxidative DNA damage and subsequent cell cycle arrest is related to the availability of GSH, at least, to some extent, under the current culture ...DSBs induced by methacrylic monomers ...
14
PubMedCentral-PMC4808044.pdf
... cycle, apoptosis and cellular stress. Inhibition of growth induced by simvastatin led to G1 cell cycle arrest and an increase in Annexin V expression in our ovarian cancer cells, which was ...
15
Diabetes mellitus-induced male reproductive impairment: The role of natural products: A review
... Several reports have linked DM with disruption of the hypothalamic–pituitary–gonadal (HPG) axis, thus altering the concentrations of testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) in males. ...
10
Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
... The impact of IFNα on the iPSC-derived beta cells was similar to the human adult beta cell situation, but some differences were detected. Thus, iPSC-derived pan- creatic endocrine cells express the IFNα receptor and ...
15
Angiotensin II-Induced Mesangial Cell Apoptosis: Role of Oxidative Stress
... Fig. 5. (A) The effects of various inhibitors of NADPH oxidase on ANG II- induced mesangial cell superoxide production. Equal numbers of MCs were incubated in media containing either buffer (control), DPI (10 ...
11
Original Article Protective effects of melatonin on lung and liver injuries in a rat model of acute sepsis
... oxidative stress, as shown by the reduction of malondialdehyde, increased activities of superoxide dismutase and catalase, and elevation of glutathione ...cell apoptosis by reducing caspase-3 activity, ...
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