stroke-prone spontaneously hypertensive rat
Association and cosegregation of stroke with impaired endothelium dependent vasorelaxation in stroke prone, spontaneously hypertensive rats
... of hypertensive ventricular hypertrophy mirror observations in human hypertension, these animals, by and large, fail to mani- fest any of the morbid conditions, such as coronary, peripheral, or cerebrovascular ...
7
Regulation of blood pressure and glucose metabolism induced by L- tryptophan in stroke-prone spontaneously hypertensive rats
... Plasma levels of total cholesterol, triacylglycerol, NEFA, HDL-cholesterol, glucose, blood urea nitrogen, and crea- tinine levels were measured by colorimetric enzymatic methods (Wako Pure Chemical Co.). The LDL-choles- ...
7
Arginine vasopressin altered the expression of monocarboxylate transporters in cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats
... Primary dissociated astrocytes were isolated from fetal cerebral WKY/Izm, SHR/Izm, and SHRSP/Izm rats (Japan SLC, Inc., Tokyo, Japan) and the congenic rat strain, SHRpch1_18, as described previously [30, 31]. The ...
12
Behavioural effects of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis protocol
... The study selection and inclusion is going to be performed with a prescreening based on the title and abstract. If an exclusion criterion is not clearly observed (eg, reviews or editorials, studies in human subjects), a ...
5
Effects of Angiotensin II Type 1 receptor blocker and adiponectin on adipocyte dysfunction in stroke-prone spontaneously hypertensive rats
... On the other hand, the mRNA expression levels of adiponectin and PPARγ were also increased in the candesartan-treated group. PPARγ is nuclear transcription factor in adipocytes, where it control the expression of nu- ...
6
Differential effects of dietary canola and soybean oil intake on oxidative stress in stroke-prone spontaneously hypertensive rats
... The stroke-prone spontaneously hypertensive (SHRSP) rat is a model of human essential hypertension and stroke, and is derived from the spontaneously hyperten- sive ...
8
The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats
... The results of the present study show an increase in blood pressure in both the canola oil and soybean oil groups with salt compared to the dietary groups without salt at the end of the feeding trial. The association ...
10
Stimulation of Adipose Tissue Lipoprotein Lipase Activity Improves Glucose Metabolism and Increases High Density Lipoprotein Cholesterol in the Spontaneously Hypertensive Stroke-Prone Rat
... In studies reviewed by Pape and Bisgaier (1998) reviewed the discovery of HDL-elevating therapy and how that impacted TG-rich lipoproteins, and suggested that the reduction in apoC-III allows for more rapid uptake of ...
10
Cardiopulmonary responses of Wistar Kyoto (WKY), spontaneously hypertensive rats (SHR) and stroke prone SHR (SHRSP) to particulate matter (PM) exposure
... The selection of exposure dose and method is guided by the hypothesis being evaluated. Ideally, exposures should mimic real world exposures-in this case, long term inhalation of PM at low concentrations. However, it is ...
83
Fermented rice bran supplementation mitigates metabolic syndrome in stroke prone spontaneously hypertensive rats
... The serum levels of glucose, total cholesterol (TC), tri- glycerides (TG), and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic colorimetric methods (Wako Pure Chemical Industries, Ltd.) according ...
11
Protective Effects of Nobiletin on Hypertension and Cerebral Thrombosis in Stroke Prone Spontaneously Hypertensive Rats (SHRSP)
... in hypertensive animal models stimulated platelets [38], and others have shown that chronic exposure to oxidative stress in spon- taneously hypertensive rat (SHR) and SHRSP might contribute to ...
8
Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat
... connected to catheters implanted in the lower abdominal aorta (Data Sciences Intl., St. Paul, MN) (19–22). Pulsatile pressures and heart rates were recorded in 5-s bursts every 5 min during the day (0600– 1800) and night ...
6
Sympathetic Hyperactivity during Hypothalamic Stimulation in Spontaneously Hypertensive Rats
... To determine whether sympathetic hyperactivity of hypothalamic origin contributes to keep blood pressures high in spontaneous hypertension, aortic pressures and sympathetic nerve spike potentials were recorded during ...
8
Control of intestinal fluid transport in normotensive and spontaneously hypertensive rats
... Exogenous angiotensin II inhibits renin release without effecting renal blood flow or aldosterone secretion Vander and Geelhoed, 1965; Bunag et al., 1967, SL^gesting that endogenous angi[r] ...
267
Prestroke Proteomic Changes in Cerebral Microvessels in Stroke-Prone, Transgenic[hCETP]-Hyperlipidemic, Dahl Salt-Sensitive Hypertensive Rats
... Processing of proteins and tandem mass spectral analysis was done as de- scribed (18). Tandem MS/MS spectra were collected for the top 10 ions of each MS scan. Spectra were queried against the rat NCBI RefSeq ...
11
Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat
... to rat AHSG (Santa Cruz Biotechnology, Santa Cruz, CA) at a 1:10,000 dilution and to human CES3 (Santa Cruz Biotechnology) at a 1:10,000 dilution, and a rabbit polyclonal antibody to MGLL (Abcam, Cambridge, UK) at ...
9
Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats
... slices were acquired in short-axis orientation covering the entire heart. To cover the cardiac cycle ten time frames for each slide of the heart were retrospectively reconstructed with the customized program IntraAngio ...
10
Spontaneously hypertensive rat vascular smooth muscle cells in culture exhibit increased growth and Na+/H+ exchange
... The cellular mechanisms responsible for abnormalities in spontaneously hypertensive rat (SHR) vascular smooth muscle cell (VSMC) growth and vasoreactivity are not defined. Because Na+/H+ exchange, ...
9
Defective dopamine 1 receptor adenylate cyclase coupling in the proximal convoluted tubule from the spontaneously hypertensive rat
... The natriuretic effect of DA-1 agonists is less in the spontaneously hypertensive rat (SHR) than its normotensive control, the Wistar-Kyoto rat (WKY). To determine a mechanism of the decreased ...
9
Enrichment Discrimination Behavior in Spontaneously Hypertensive Rats
... The ED-low phenotype represented by left part of the distribution was characterized by the ED-ratio range 0 - 199 and mean 104.8 ± 6.2. The ratio shows that the rats spend almost the same time in the enriched arms of the ...
6