Stroke-Prone Spontaneously Hypertensive Rat (SHRSP)
Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains
... The stroke-prone spontaneously hypertensive rat (SHRSP) develops severe hypertension and, as opposed to its related control strain, the stroke-resistant SHR, shows an increased ...
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Association and cosegregation of stroke with impaired endothelium dependent vasorelaxation in stroke prone, spontaneously hypertensive rats
... of hypertensive ventricular hypertrophy mirror observations in human hypertension, these animals, by and large, fail to mani- fest any of the morbid conditions, such as coronary, peripheral, or cerebrovascular ...
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Protective Effects of Nobiletin on Hypertension and Cerebral Thrombosis in Stroke Prone Spontaneously Hypertensive Rats (SHRSP)
... in hypertensive animal models stimulated platelets [38], and others have shown that chronic exposure to oxidative stress in spon- taneously hypertensive rat (SHR) and SHRSP might contribute to ...
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Arginine vasopressin altered the expression of monocarboxylate transporters in cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats
... In summary, we demonstrated that cultured astrocytes iso- lated from SHRSP/Izm and SHRpch1_18 rats differed from those obtained from the WKY/Izm strain in regard to their responsiveness to AVP or H/R conditions. Namely, ...
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Cardiopulmonary responses of Wistar Kyoto (WKY), spontaneously hypertensive rats (SHR) and stroke prone SHR (SHRSP) to particulate matter (PM) exposure
... The selection of exposure dose and method is guided by the hypothesis being evaluated. Ideally, exposures should mimic real world exposures-in this case, long term inhalation of PM at low concentrations. However, it is ...
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The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats
... The results of the present study show an increase in blood pressure in both the canola oil and soybean oil groups with salt compared to the dietary groups without salt at the end of the feeding trial. The association ...
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Differential effects of dietary canola and soybean oil intake on oxidative stress in stroke-prone spontaneously hypertensive rats
... The stroke-prone spontaneously hypertensive (SHRSP) rat is a model of human essential hypertension and stroke, and is derived from the spontaneously hyperten- sive ...
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Stimulation of Adipose Tissue Lipoprotein Lipase Activity Improves Glucose Metabolism and Increases High Density Lipoprotein Cholesterol in the Spontaneously Hypertensive Stroke-Prone Rat
... In studies reviewed by Pape and Bisgaier (1998) reviewed the discovery of HDL-elevating therapy and how that impacted TG-rich lipoproteins, and suggested that the reduction in apoC-III allows for more rapid uptake of ...
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Regulation of blood pressure and glucose metabolism induced by L- tryptophan in stroke-prone spontaneously hypertensive rats
... We divided 9-week-old SHRSP into three groups and fed them an AIN-93M-based diet for 3 weeks. The diet of the control group was not supplemented, whereas the diets of the other two groups were supplemented with L-Trp at ...
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Fermented rice bran supplementation mitigates metabolic syndrome in stroke prone spontaneously hypertensive rats
... pressure as well as blood glucose and insulin levels [31]. It was observed that the L-tryptophan content of FRB (30 mg/100 g) is much higher than that of Non-FRB (4 mg/100 g). In the liver, there is de novo glucose ...
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Behavioural effects of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis protocol
... The study selection and inclusion is going to be performed with a prescreening based on the title and abstract. If an exclusion criterion is not clearly observed (eg, reviews or editorials, studies in human subjects), a ...
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Effects of Angiotensin II Type 1 receptor blocker and adiponectin on adipocyte dysfunction in stroke-prone spontaneously hypertensive rats
... On the other hand, the mRNA expression levels of adiponectin and PPARγ were also increased in the candesartan-treated group. PPARγ is nuclear transcription factor in adipocytes, where it control the expression of nu- ...
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Instrumental conditioning for food reinforcement in the spontaneously hypertensive rat model of attention deficit hyperactivity disorder
... The spontaneously hyperten- sive rat (SHR) is one suggested animal model of ADHD, considered to best model ADHD-C [18], but it is gener- ally accepted to exhibit good ...
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Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat
... individual rat liver tissue sam- ples was used for cDNA synthesis using a T7 promoter primer with Agilent low RNA input fluorescent linear amplification ...a rat Agi- lent Oligo 22 k microarray ...
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Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen deficient mice by the human renin and human angiotensinogen genes
... Experimental strategy. The long term goal of the studies of which the present experiments are a part is to develop animal models to examine the physiological importance of candidate AGT gene variants reported to be ...
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A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure
... the spontaneously hypertensive rat, cosegregates with an increase in blood pressure in F2 rats derived from a cross of the spontaneously hypertensive rat with normotensive ...
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Enrichment Discrimination Behavior in Spontaneously Hypertensive Rats
... SH rat population with regard to attention to objects en- riching an empty cross-maze (enrichment discrimination, ED) and, in case of non-homogeneity, to evaluate effects of clinically efficient drug atomoxetine ...
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EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR A AND ITS RECEPTORS IN UTEROPLACENTAL TISSUES OF THE NORMOTENSIVE AND HYPERTENSIVE PREGNANT RAT
... normal rat uteroplacental tissues at early, mid and late ...the spontaneously hypertensive rat (SHR) at 7, 11 and 19 days of ...gestation. Spontaneously hypertensive rats have ...
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Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure
... In the study in Dahl rats in which an RFLP in the renin gene cosegregated with increased blood pressure 15, it appeared that two doses of the Dahl S renin allele conferred a greater incr[r] ...
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Calcium and sodium transport and vitamin D metabolism in the spontaneously hypertensive rat
... the spontaneously hypertensive (SH) rat than in the normotensive Wistar- Kyoto (WKy) ...SH rat is ...SH rat was decreased (P less than ...
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