stromal fibroblasts
Notch1—WISP-1 axis determines the regulatory role of mesenchymal stem cell-derived stromal fibroblasts in melanoma metastasis
... of fibroblasts, which is partially mediated by WISP-1, was relievable when the Notch activation was countered with dominant-negative mutant of Master-mind like 1 (DN-MAML-1) ...in fibroblasts could ...
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AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells
... activated fibroblasts in organotypic cultures with recombinant IL1B inhibited epithelial cell ...between stromal fibroblasts and cancer cells has been shown in other cancers and in addition to ...
14
Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells
... in stromal fibroblasts, because far fewer fibroblasts in the tumor tissue showed detectable levels of the Int6 ...on fibroblasts, we silenced INT6 expression in immortalized human mammary ...
10
Original Article Mucinous and serous ovarian carcinoma cells interact differently with stromal fibroblasts
... In addition to inhibiting the activation of MMPs, TIMP2 is associated with tumor development and progression by MMP-dependent and -inde- pendent mechanisms [28]. However, paradoxi- cal results have been reported, such as ...
11
Genomics and proteomics approaches to the study of cancer-stroma interactions
... tumor stromal fibroblasts were grown in culture chambers (Nunc, Naperville, IL, USA) and, after 3 days, the chambers were carefully removed, and the slides with adherent cells were fixed in 4% par- ...
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PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis
... precursor fibroblasts differentiate into white adipocytes in the ...of stromal fibroblasts. This imbalance between adipocytes and stromal cells was accompanied by overexpression of the cell ...
12
Syndecan 1 induction in lung microenvironment supports the establishment of breast tumor metastases
... in stromal fibroblasts within the metastatic microenvironment and in normal airway epithelial cells but not in other cells (endothelial cells, α -smooth muscle actin positive cells, leucocytes, ...
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Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures
... This study is the first to report the response of primary oesoph- ageal cells (epithelial cells and stromal fibroblasts) to synthetic self-assembling peptide hydrogels. A library of peptide hydro- gels ...
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Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma
... Since stromal fibroblasts play critical roles in tissue regeneration and FAP + stromal cells have been demonstrated to present in injury sites and atherosclerotic lesions (Brokopp et ...
242
Li Fraumeni syndrome, cancer and senescence: a new hypothesis
... activated stromal fibroblasts respond to the oxidative stress generated by tumours by becoming autophagic and switching metabolism to aerobic glycolysis, which gener- ates high-energy fuels that can drive ...
6
SDF-1 in Mammary Fibroblasts of Bovine with Mastitis Induces EMT and Inflammatory Response of Epithelial Cells
... of stromal fibroblasts in the process of inflammatory response and even progressive fibrosis if it was caused by the inflammation in bovine mammary ...of fibroblasts, their differentiation into ...
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Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells
... as fibroblasts to establish reactive ...cancer-associated fibroblasts set up a synergistic relationship with tumour cells, that contributes to their malignancy and resistance to ...transform stromal ...
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Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression
... Over the years, an increasing number of studies have revealed that the A2B receptor (A2BR) plays an important role in tumor-promoting effects of adenosine. A2BR activates multiple downstream pathways, including cAMP and ...
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EXPERIMENTAL AUTORADIOGRAPHY AUTORADIOGRAPHICAL STUDY OF THE REGENERATION OF DAMAGED CORNEA STROMA
... [14] Stromal keratocyte apoptosis has been well-characterized as an early initiating event of the corneal wound healing response triggering subsequent cellular process that include bone marrow-derived cell ...
6
Breast Cancer Regulation and Progression: A Review on Genetics and Microenvironment of Breast Cancer
... 62 A co- culture model has compared the luminal cells, myoepithelial cells and stromal fibroblasts between normal and malignant breast tissue.. The 3D heterotypic culture [r] ...
8
Bone marrow mesenchymal stem cells as nuclear donors improve viability and health of cloned horses
... multipotent stem cells that are easy to maintain in culture and behave similar to fibroblasts in vitro, which facilitates their manipulation and cell cycle synchronization. Not only the multipotent capacity of the ...
10
Impaired osteoblast and osteoclast function characterize the osteoporosis of Snyder - Robinson syndrome
... cultured fibroblasts and ...in fibroblasts and ...patient fibroblasts, * p < ...marrow stromal cells (hBMSCs) isolated from Patient II-1 sample is markedly lower than that of an unaffected ...
13
Role of mesenchymal cells in the natural history of ovarian cancer: a review
... resulting stromal modifications (increased ves- sel stability and matrix degradation) are compatible with tumor expansion, stimulated simultaneously by CAFs re- lease of tumor-supportive growth factors, including ...
17
Adipocyte derived endotrophin promotes malignant tumor progression
... and fibroblasts during the wound repair ...activates fibroblasts in the tumor stroma, drasti- cally increasing local fibrosis and eventually enhancing metastatic ...
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Modulation of stromal cell-derived factor 1 alpha (SDF-1α) and its receptor CXCR4 in Porphyromonas gingivalis-induced periodontal inflammation
... by fibroblasts, the most numerous resident non-professional immune cells in the periodontium, controls the secretion of important cyto- kines that modulate the inflammatory ...
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