Stromal keratitis
Reversible Nerve Damage and Corneal Pathology in Murine Herpes Simplex Stromal Keratitis
... Herpes simplex virus type 1 (HSV-1) shedding from sensory neurons can trigger recurrent bouts of herpes stromal keratitis (HSK), an inflammatory response that leads to progressive corneal scarring and ...
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Is Microsporidial keratitis an emerging cause of stromal keratitis? – a case series study
... microsporidial stromal keratitis diagnosed between January 2002 and June 2004 were reviewed retrospectively for clinical data, microbiologic and histopathologic ...deep stromal infiltrates, of ...
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Absence of CXCL10 Aggravates Herpes Stromal Keratitis with Reduced Primary Neutrophil Influx in Mice
... Herpes simplex virus 1 (HSV-1) replication initiates inflammation and angiogenesis responses in the cornea to result in herpetic stromal keratitis (HSK), which is a leading cause of infection-induced vision ...
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Absence of Macrophage Inflammatory Protein-1α Prevents the Development of Blinding Herpes Stromal Keratitis
... T-cell count per field (36 fields counted) in 1 / 1 hosts was 26 6 2 (P < 0.001). In addition, neutrophil counts in the 2 / 2 mouse corneas were reduced by >80% in comparison to the wild-type controls. At 2 weeks ...
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Azacytidine Treatment Inhibits the Progression of Herpes Stromal Keratitis by Enhancing Regulatory T Cell Function
... ABSTRACT Ocular infection with herpes simplex virus 1 (HSV-1) sets off an inflamma- tory reaction in the cornea which leads to both virus clearance and chronic lesions that are orchestrated by CD4 T cells. Approaches that ...
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Role of Inflammatory Cytokine-Induced Cycloxygenase 2 in the Ocular Immunopathologic Disease Herpetic Stromal Keratitis
... Herpetic stromal keratitis (HSK) is a chronic immunoin- flammatory reaction in the corneal stroma caused by ocular infection with herpes simplex virus (HSV) ...the stromal keratitis (SK) ...
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Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice
... ABSTRACT Sex differences related to immune response and inflammation play a role in the susceptibility and pathogenesis of a variety of viral infections and disease (S. L. Klein, Bioessays 34:1050 –1059, 2012, ...
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Contribution of Vascular Endothelial Growth Factor in the Neovascularization Process during the Pathogenesis of Herpetic Stromal Keratitis
... Clinical scoring system. Mice were examined at different time points after infection for the development of clinical lesions by slit lamp microscopy (Kowa Co., Nagoya, Japan) and stereomicroscopy (Leica Microscopy ...
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Dendritic Cell Autophagy Contributes to Herpes Simplex Virus Driven Stromal Keratitis and Immunopathology
... ABSTRACT Herpetic stromal keratitis (HSK) is a blinding ocular disease that is initiated by HSV-1 and characterized by chronic inflammation in the cornea. Although HSK immunopathology of the cornea is well ...
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Successful resolution of stromal keratitis and uveitis using canakinumab in a patient with chronic infantile neurologic, cutaneous, and articular syndrome: a case study
... syndrome-related stromal keratitis and uve- itis in an adult female, which was successfully treated with ...recurrent stromal keratitis and anterior ...
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Innate Recognition Network Driving Herpes Simplex Virus-Induced Corneal Immunopathology: Role of the Toll Pathway in Early Inflammatory Events in Stromal Keratitis
... The most dramatic effects were observed when TLR2 ⫺/⫺ mice were infected with a low dose of a virulent strain of HSV. Compared to WT animals, TLR2 ⫺/⫺ mice showed consider- able resistance to disease expression. Fewer ...
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Herpes simplex virus-induced stromal keratitis: role of T-lymphocyte subsets in immunopathology.
... Depleted and nonspecific mouse ascites-treated control mice were infected topically on the corneas with herpes simplex virus type 1, and the induction of various immune parameters during[r] ...
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Herpetic stromal keratitis in the reconstituted scid mouse model.
... I One day after infection or sham infection, mice were given an adoptive transfer of various concentrations of unfractionated immune lymphocytes from donor BALB/c mice or splenocytes fro[r] ...
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Clinical pattern of recurrent herpes simplex keratitis
... Their use is restricted to the management of stromal keratitis and herpetic uveitis. Steroids do not appear to increase the risk of acquiring herpes simplex virus infection but certainly promote severity of ...
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<em>Candida albicans</em> keratitis in an immunocompromised patient
... infiltrates, stromal keratitis, disciform keratitis, uveitis, and increased intraocular ...Varicella keratitis is a self-limited ...rare. Stromal keratitis and uveitis occur in ...
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<p>Clinical Pattern And Visual Impairment Associated With Herpes Simplex Keratitis</p>
... epithelial keratitis was made if the lesion comprised either dendritic ulcers (lesions with a branching, linear pattern with terminal bulbs), or geographic ulcers (broad ulcers with swollen, scalloped, or ...
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Original Article Clinical Spectrum of Herpes Simplex Keratitis in Patients Attending various Health Institutions in North India
... the stromal keratitis was accounted for by five zones: central, superonasal, superotemporal, inferonasal and ...epithelial keratitis just, stromal keratitis or endothelitis/kerato ...
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Ocular involvement associated with varicella in adults
... A 39-year-old man, complained about a 3-day history of bilateral blurred vision. He had a past medical history of kidney transplantation 5 years ago and was receiving systemic immunosuppressive therapy. The patient was ...
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... bacterial keratitis showed a good ...HSV stromal keratitis, one had a history of previous corneal graft because of HSV keratitis and had a good response to ...infectious keratitis are ...
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Translationally Controlled Tumour Protein (TCTP) is present in human cornea and increases in herpetic keratitis
... Background: Translationally Controlled Tumour protein is a multifunctional calcium binding protein which has an important role in apoptosis, calcium levels balance and immunological response. The aim of this study was to ...
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