structure-activity relationship
A Review of Structure Activity Relationship of Amiodarone and Its Derivatives
... Structure Activity Relationship forms the basis of Rational Drug Design in the circles of pharma- ceutical and medicinal ...the structure activity relationship of some of the ...
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Design, Synthesis and Studies of Structure Activity Relationship of γ butyrolactones for Evaluation of Analgesic Activity
... In the analgesic studies (Figure 3) it has been observed that the compounds substituted with halogens, hydroxyl and methoxy group shows significant analgesic activity. The compounds are found to increase in ...
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3D QSAR STUDIES ON THIAZOLIDINONE DERIVATIVES AS POTENTIAL EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS
... Quantitative Structure Activity Relationship (QSAR) technique belongs to the paradigm of rational drug ...statistical relationship between the properties of amolecule (physicochemical, ...
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Validation of quantitative structure activity relationship (QSAR) model for photosensitizer activity prediction
... Verloop parameters are sets of multi-dimensional steric descriptors. They can be used to characterize the shape and volume of the substituent, which are important in explaining the steric influence of substituents in the ...
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Quantitative Structure Activity Relationship Study of Some Antipsychotics by Multiple Linear Regressions
... Quantitative structure-activity relationship studies have been performed to correlate the molecular characteris- tics of observed compounds with their retention as well as with their ...
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3D QSAR OF N SUBSTITUTED IMIDAZOLES AS ANTIFUNGAL AGENTS
... crystal structure of Candida albican cytochrome P450 dependent 14-α-demethylase (CA-CYP51), the rational design of new antifungals has been carried out using various methods such as homology modeling, [6] ...
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A structure activity relationship for induction of meningeal inflammation by muramyl peptides
... adjuvant effects, cytotoxicity, and induction of sleep. Mixtures of peptidoglycan components also induce inflammation in the lung, subarachnoid space, and joint, but the structural requirements for activity are ...
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Structure Activity Relationship and Mechanism of Action of Hydrazide Derivatives as Antimicrobial Molecule
... Hydrazide and their heterocyclic derivatives exhibiting wide range of biological activities. Among different biological activities antimicrobial, antitubercular, antiamoebic and antimalarial are noteworthy. Further, ...
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Role of calmodulin in platelet aggregation Structure activity relationship of calmodulin antagonists
... their structure-activity relationships with calmodulin antagonistic actions and their potencies in inhibiting human platelet aggregation in vitro were ...
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Quantitative structure activity relationship study of parasubstituted trans and cis tamoxifen derivatives
... crystal structure of the 4-hydroxytamoxifen (4OHT) bound to the human estrogen receptor alpha (hER α ) ligand-binding domain (LBD) retrieved from the Protein Data Bank (PDB ID code ...
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Quantitative structure activity relationship of matrix metalloproteinase inhibitors based on topological descriptors
... variable. The Project Leader program associated with CAChe Pro of Fujitsu has been used for multiple linear regressions (MLR) analysis and ninety equations were developed. The study concluded that topological ...
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Structure-activity relationship models for hazard assessment and risk management of engineered nanomaterials
... quantitative structure activity relationship analysis (QSAR), with nanotoxicology will facilitate the risk assessment of the large number of ENMs and their ...
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Validation Method Used In Quantitative Structure Activity Relationship
... Quantitative structure activity relationship is study of relationship between physiochemical (independent) properties and biological (dependent) activity of bioactive ...the ...
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Application of QSAR Methods on the Study of Bioactive Molecules Derived from Isatin
... anticancer activity could be explained by a number of electronic and topologic ...isatin activity reveals that a decrease in the value of pIC 50 , While the positive correlation of the descriptors ...
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IN VITRO EVALUATION OF ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF SERIES OF NEW PYRAZOLE DERIVATIVES; A STUDY ON THE STRUCTURE ACTIVITY RELATIONSHIP
... The stability of the title compounds was expected to be the driving force for antioxidant activity of the title compounds. From the experimental results, the stiochiometry of the reaction was found to be 1:2 for ...
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Original Article Structure-activity relationship of berberine derivatives for their glucose-lowering activities
... As BBR could activate AMPK, which was a key molecule for cellular energy balance [2, 5, 10, 11], we determined the influence of 3e on AMPK activity by western blot. The results proved that 20 μM of 3e treatment ...
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Synthesis, characterization, and anticancer activity of benzoxazole derivatives
... The anti-microbial activity for the sample was carried out by Disc Diffusion Technique [14]. The test microorganisms (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida ...
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Scalable total synthesis and comprehensive structure–activity relationship studies of the phytotoxin coronatine
... phytotoxic activity separately, however, this is greatly enhanced when the components are coupled to give the parent structure 24 ...biological activity, mimicking the side chain configuration of JA- ...
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Scalable total synthesis and comprehensive structure–activity relationship studies of the phytotoxin coronatine
... Natural phytotoxins are valuable starting points for agrochemical design. Acting as a jasmonate agonist, coronatine represents an attractive herbicidal lead with novel mode of action and has been an important synthetic ...
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The relationship of physico chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids
... Each mono-protonated cinchona alkaloid structure was built in HyperChem Release 7 for Windows (Hypercube Inc. Gainesville, Florida) using a molecular mechanics procedure under MM+ [34] with bond-length restraints ...
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