Structure activity Relationship
Quantitative structure activity relationship of matrix metalloproteinase inhibitors based on topological descriptors
... Quantitative structure-activity relationship of nineteen matrix metalloproteinase inhibitors based on topological descriptors has been ...biological activity in term of IC 50 values as ...
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A Categorical Structure-Activity Relationship Analysis of the Developmental Toxicity of Antithyroid Drugs
... of structure-activity relationship (SAR) models generated by MultiCASE for studying and predicting developmental toxicity in diverse species including humans ...
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A structure activity relationship for induction of meningeal inflammation by muramyl peptides
... disaccharide-tetrapeptide, the major component of all gram-negative peptidoglycans, induced CSF leukocytosis and protein influx at doses as low as 0.4 microgram (0.42 nM). Modification of the N-acetyl muramic acid or ...
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Design, Synthesis and Studies of Structure Activity Relationship of γ butyrolactones for Evaluation of Analgesic Activity
... analgesic activity in mice by hot plate ...analgesic activity and can serve as future potential to be active as analgesic agents by inhibiting cyclooxygenase II ...analgesic activity of the compounds ...
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Quantitative Structure Activity Relationship Study of Some Antipsychotics by Multiple Linear Regressions
... Chromatography is a powerful technique for the measurement of physicochemical properties that are used as parameters to correlate biological activities with structures in quantitative structure-activity ...
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QSAR DataBank repository: open and linked qualitative and quantitative structure–activity relationship models
... Background: Structure–activity relationship models have been used to gain insight into chemical and physical processes in biomedicine, toxicology, biotechnology, ...quantitative ...
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Multi-task learning with a natural metric for quantitative structure activity relationship learning
... quantitative structure activity relationship; MTL: multi-task learning; DHFR: dihydrofolate reductase; MHC: histocompatibility complex; RNA: ribonucleic acid; DRN: deep relationship networks; ...
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Quantitative Structure Activity Relationship Study of Naphthoquinone Analogs as Possible DNA Topoisomerase Inhibitors
... anticancer activity against HT-29 ...quantitative structure-activity relationship between anticancer activities with the series of 26 bioactive molecules derived from NQ moieties were ...
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Novel Inhibitors of Influenza Virus Fusion: Structure-Activity Relationship and Interaction with the Viral Hemagglutinin
... defined structure-activity relationship was ...No activity was observed for A/H1N1, A/H5N1, A/H7N2, and B ...The activity of 4c was reduced considerably when added 30 min or later ...
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Scalable total synthesis and comprehensive structure–activity relationship studies of the phytotoxin coronatine
... COR (1) is composed of two constituent natural products: the cis-fused 5,6-bicyclic polyketide core unit, coronafacic acid (CFA, 2), coupled to an isoleucine (Ile)-derived amino acid, coronamic acid (CMA, 3), through an ...
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Quantitative structure-activity relationship of some 1-benzylbenzimidazole derivatives as antifungal agents
... antifungal activity of some 1-benzylbenzimidazole derivatives against yeast Saccharomyces cerevisiae was ...antifungal activity and minimum inhibitory concentration (MIC) was determined for all the ...
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Design, Synthesis, and Structure Activity Relationship of a Novel Series of GluN2C-Selective Potentiators
... a structure − activity relationship, which led to the identi fi cation of a novel series of compounds with potency in the low micromolar range and high selectivity for recombinant GluN2C-containing ...
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Structure Activity Relationship and Mechanism of Action of Hydrazide Derivatives as Antimicrobial Molecule
... Hydrazide and their heterocyclic derivatives exhibiting wide range of biological activities. Among different biological activities antimicrobial, antitubercular, antiamoebic and antimalarial are noteworthy. Further, ...
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Structure- Activity Relationship (Sar) Of Cyanoethylated Aromatic Amines
... The structure activity relationship among the synthesized azo dyes were measured against eight pathogens [5], ...The activity of the compounds against bacterial strains are provided in table ...
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A Review of Structure Activity Relationship of Amiodarone and Its Derivatives
... Structure Activity Relationship forms the basis of Rational Drug Design in the circles of pharma- ceutical and medicinal ...the structure activity relationship of some of the ...
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Structure-activity relationship models for hazard assessment and risk management of engineered nanomaterials
... quantitative structure activity relationship analysis (QSAR), with nanotoxicology will facilitate the risk assessment of the large number of ENMs and their ...
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Quantitative Structure Activity Relationship Analysis of Selected Chalcone Derivatives as Mycobacterium tuberculosis Inhibitors
... anti-tuberculosis activity by chalcone derivatives of 1,3-diphenylprop-2-ene-1-one, quantitative structure activity relationship (QSAR) was performed using genetic function approximation ...
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Validation Method Used In Quantitative Structure Activity Relationship
... Quantitative structure activity relationship is study of relationship between physiochemical (independent) properties and biological (dependent) activity of bioactive ...the ...
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Quantitative Structure Activity Relationship (QSAR) Analysis on Arylbenzofuran Derivatives as Histamine H3 Antagonists
... The thirst for discovery of new chemical entities of therapeutic interest has been continued since for many years to medicinal chemistry experts. In recent years, a substantial progress that has been made by ...
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Scalable total synthesis and comprehensive structure–activity relationship studies of the phytotoxin coronatine
... Natural phytotoxins are valuable starting points for agrochemical design. Acting as a jasmonate agonist, coronatine represents an attractive herbicidal lead with novel mode of action and has been an important synthetic ...
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