Substance P
Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase
... Substance P and related tachykinins contribute to the airway hyperresponsiveness caused by toluene diisocyanate (TDI) in guinea ...of substance P-induced ...to substance P by ...
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Relationship between Dysphagia and Serum Substance P Level in Chronic Central Nervous Disease
... Substance P (SP) is a neurotransmitter belonging to the tachykinin peptide family. Widely distributed throughout the peripheral and central nervous systems of vertebrates, SP is known to have a wide range ...
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Interactions of bombesin and substance P at the feline lower esophageal sphincter
... The substance P antagonist [D-Pro2, D-Trp7,9]substance P also significantly inhibited the LES response to bombesin (P less than ...mmHg, P less than ...
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Substance P and Neurotensin: Discovery, Isolation, Chemical Characterization and Physiological Studies
... Release of immunoreactive substance P I-SP has been demonstrated in vivo from mammalian spinal cord after activation of nociceptive afferents.. Neurotensin is also unevenly distributed t[r] ...
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Measurement of Plasma-Derived Substance P: Biological, Methodological, and Statistical Considerations
... The undecapeptide substance P (SP) is a member of the tachykinin family and was first sequenced by Chang et al. (8). SP was subsequently characterized as a neurotransmitter (31, 32, 33). Elevation of serum ...
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Development and Evaluation of a Chromatographic Procedure for Partial Purification of Substance P with Quantitation by an Enzyme Immunoassay
... Substance P (SP), a bioactive undecapeptide, was discovered in 1930 (7) and is found at varying concentrations in the central nervous system (11). Observations by Lembeck that there is a much higher ...
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Serum substance P levels in patients with chronic schizophrenia treated with typical or atypical antipsychotics
... serum substance P levels comparable with control subjects ...respectively; p = ...serum substance P levels ...serum substance P levels at ...serum substance ...
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Measles virus substance P receptor interactions Possible novel mechanism of viral fusion
... substance P (SP). In addition, the oligopeptide Z-D-Phe-L-Phe-Gly, also homologous to F and SP, inhibits MV fusion with target cells. These observations raise the question of whether MV uses the SP receptor ...
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Review Article Substance P and its role in viral infection
... Abstract: Substance P (SP) is an 11-amino acid neuropeptide of the tachykinin family that preferentially activates the neurokinin-1 receptor (NK1R). Early studies identified a role for SP and the NK1R in ...
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Substance P in Polymicrobial Sepsis: Molecular Fingerprint of Lung Injury in Preprotachykinin-A−/− Mice
... neuropeptide substance P, has been shown to protect against lung injury and mortality in ...of substance P resulted in a significantly different expression profile of genes involved in ...
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Original Article The effects and mechanism of substance P in sedative and hypnotic of isoflurane mice
... neuropeptide substance found in the ...tained substance P and the axonal fibers proj- ect to the pontine reticular formation that induces paradoxical ...
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Evaluation of Serum Substance P Level in Chronic Urticaria and Correlation with Disease Severity
... As for the pathogenesis of CU, there have been numerous theories. Yet, none have been proven on an absolute basis. Though the majority of the related literature has looked into the autoimmunity theory, there are several ...
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Original Article Expression of substance P in rat periodontal alveolar bone after denervation
... neuropeptide substance P changes in peri- odontal alveolar bone after ...that substance P significantly decreases in the early stages after injury, and may be use- ful as a sensitive index to ...
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Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig Possible role of free radicals
... aerosolized substance P in the absence or presence of the NEP inhibitor ...to substance P were greater in cigarette smoke-exposed guinea pigs than in air-exposed ...to substance ...
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Substance P and Antagonists of the Neurokinin-1 Receptor in Neuroinflammation Associated with Infectious and Neurodegenerative Diseases of the Central Nervous System
... that substance P (SP) and its preferred receptor neurokinin-1 (NK1R) play in neuroinflammation associated with select bacterial, viral, parasitic, and neurodegenerative diseases of the central nervous ...
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Substance P recognition by a subset of human T lymphocytes
... fluorescein-labeled substance P and [3H]substance P to T-lymphocytes at concentrations that suppressed the proliferative response to substance ...P. Substance P, ...
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Neutral endopeptidase inhibitors potentiate substance P and capsaicin induced cough in awake guinea pigs
... whether substance P or diluent alone was aerosolized, substance P (10(-16) M) caused ...potentiated substance P-induced cough; NEP inhibitors also potentiated capsaicin-induced ...
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Increased expression of matrix metalloproteinase 10, nerve growth factor and substance P in the painful degenerate intervertebral disc
... neuropeptide substance P in surgical degenerate samples but not in either PM normal or PM degen- erate ...in substance P ...through substance P) in symp- tomatic IVD ...
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Focus on the role of substance P in chronic urticaria
... NK: neurokinin; SP: substance P; FcεRI: high affinity IgE receptor; MRGPRX2: Mas-related G-protein-coupled receptor expressed on human mast cells; TNF: tumor necrosis factor; IL: inter[r] ...
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<p>Substance P modulates electroacupuncture analgesia in humanized mice with sickle cell disease</p>
... SCD. Strategies such as acupuncture have fewer side- effects than pharmacological agents. Limited evidence to date suggests that acupuncture offers pain relief in patients with SCD 2,3 and in humanized HbSS-BERK (BERK) ...
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