Substituted imidazoles
BF3/nano-sawdust as a green, biodegradable and inexpensive catalyst for one-pot synthesis of tri-substituted imidazoles under solvent free conditions
... 2,4,5-trisubstituted imidazoles was explored using dierent aldehydes, benzil, and ammonium acetate (Table ...tri- substituted imidazoles in higher yield than that of aliphatic ...
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Synthesis of Substituted Imidazoles via a Multi-Component Condensation Catalyzed by p-toluene Sulfonic Acid, PTSA
... Appropriately substituted imidazoles are extensively used as glucagon receptors 6 and CB1 cannabinoid receptor antagonists 7 , modulators of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) 8 , ...
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COMPARATIVE STUDY OF SYNTHESIS OF 2, 4, 5 TRIARYL SUBSTITUTED IMIDAZOLES UNDER SOLVENT FREE CONDITIONS USING DIFFERENT LEWIS ACIDS AS CATALYSTS
... 5-triaryl substituted imidazoles have been synthesized in very good yields under solvent-free conditions by grinding 1, 2- diketone, aromatic aldehydes and ammonium acetate in the presence of I 2 , NaH 2 PO ...
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Green Approach for the Synthesis of Tetra Substituted Imidazoles Derivatives on NH4OAc/NaHSO4 Supported onto Silica Gel under Microwave Irradiation
... catalyst can actas eco-friendly for a variety of organic transformations. It is non-volatile, recyclable, non-explosive, easy to handle. In view of the emerging importance of the heterogeneous catalyst, we wish to ...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF SOME NEW SUBSTITUTED IMIDAZOLES
... All the synthesised compounds were characterized and identified by using different physico-chemical parameters. Such as, TLC, melting point, elemental analysis, IR and 1 HNMR. From the literature survey it reveals that, ...
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Nano Copper Ferrite Catalyzed Sonochemical, One Pot Three and Four Component Synthesis of Poly Substituted Imidazoles
... of substituted imidazoles such as the hetero-cope rearrangement [11], four com- ponent condensation of arylglyoxals, primary amines, carboxylic acids and isocyanides on wangresin [12] and three component ...
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Synthesis of 2,4,5-Tri substituted Imidazoles Using Nano-[Zn-2BSMP]Cl2 as a Schiff Base Complex and Catalyst
... 2,4,5-tri substituted imidazoles by the one-pot multi- component condensation reaction of benzil with various aldehydes and ammonium acetate at 80 °C under solvent- free ...
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ANTI-ULCER ACTIVITY OF 1-SUBSTITUTED IMIDAZOLES AGAINST GASTRIC ULCERS IN RATS
... that imidazoles are very much effective on Histamine receptors which are found principally in the parietal ...1-substituted imidazoles (1a-1d, ...1-substituted imidazoles possibly led ...
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Synthesis and pharmacological evaluation of some substituted imidazoles
... 3- substituted phenyl indolo (2, 3) imidazole was prepared by condensing different aryl aldehydes with N-1-phenyl isatin in presence of ammonium acetate and glacial acetic ...
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3D QSAR OF N SUBSTITUTED IMIDAZOLES AS ANTIFUNGAL AGENTS
... The CoMFA method has been applied to a set of antifungal agents active against C. albicans. The compounds taken for the study belong to chemically diverse families of imidazole derivative. The CoMFA model explains the ...
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MOLECULAR DOCKING STUDIES OF NOVEL IMIDAZOLE ANALOGS AS HIV 1 RT INHIBITORS
... N- substituted imidazoles was performed in the non nucleoside inhibitory binding pocket of reverse transcriptase enzyme of wild type as well as resistant strains of HIV-1 virus with PDB ID 1RT2, 1JLB, 3BGR ...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEWER TETRA ARYL IMIDAZOLES
... synthesized substituted imidazoles have shown moderate to good anthelmintic ...synthesized imidazoles possessed significant antimicrobial activity against gram +ve bacteria ...
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Design, Synthesis and Evaluation of Some Novel 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) Thiourea Derivatives as Anti-HIV Agents
... of imidazoles, 2-methylimidazoles and 2-methyl-5-nitroimidazoles have been synthesized, characterized and evaluated for their antibacterial, antifungal, antidiarrheal, anticonvulsant and miscellaneous other ...
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Nano silica phosphoric acid: as a suitable catalyst for synthesis of trisubstituted imidazoles via sonication condition
... 1,2,4,5-tetra-substituted imidazoles", Tetrahedron, 65, ...1,2,4,5-tetrasubstituted imidazoles catalyzed via solid acid nano-catalyst", ...
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Molecular docking study on the interaction between 2-substituted-4,5-difuryl Imidazoles with different Protein Target for antileishmanial activity
... the imidazoles can be attributed to its hydrogen bond donor-acceptor capability as well as its high affinity for metals ...2006). Substituted imidazoles have been reported to possess ...
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Nano-SbCl5/SiO2 as an Efficient Catalyst for One-Pot Synthesis of 2, 4, 5-Trisubstituted Imidazoles Under Solvent- Free Condition
... 5-tri substituted imidazoles by condensation of aldehydes with benzil and ammonium acetate under solvent-free conditions in the presence of nano SbCl 5 /SiO 2 as catalyst (Scheme ...
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Triarylimidazoles as potent antiwear agents: Eco-friendly synthesis and materialistic approach
... triaryl substituted imidazoles were evaluated using a four-ball test ...these substituted imidazole derivatives can be used as an antiwear agent for steel ...
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Synthesis of new phenanthro imidazole derivatives in solvent free condition
... In conclusion, we benefit from one pot synthesis for the preparation of substituted imidazoles through three-component condensation of aldehyde, [9,10] phenanthroquinone, and ammonium acetate in Microwave ...
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H2-Receptor Antagonistic Activity of Some N-Substituted 2-Methyl Imidazoles
... bromo substituted phenacyl imidazoles showed significant antagonistic action against histamine only at ...phenyl substituted phenacyl imidazoles were found to be more effective in their ...
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Schiff’s bases and amides of selected five membered heterocyclic compounds: A review
... derivatives, imidazoles are common scaffolds in highly significant biomolecules, including biotin, the essential amino acid histidine, histamine, purines, the pilocarpine alkaloids [8,9]and other alkaloids, which ...
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