1-& 5-substituted tetrazoles
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 5-SUBSTITUTED 1(H)-TETRAZOLES
... because of their wide utility. [6] These include the cyclization reaction of amines, or its hydrochloride salt, with an orthocarboxylic acid ester and a hydrazoic acid metal salt in the presence of acetic acid or ...
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Nano Silica Melamine Trisulfonic Acid as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 5-Substituted-1H-Tetrazoles
... Tetrazoles are an important class of nitrogen-rich heterocycles with a wide range of applications in organic synthesis, coordination and medicinal chemistry ...[4-6]. Tetrazoles have also been frequently ...
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Theoretical Studies on Mild Steel Corrosion Inhibition by 5- Substituted 1H-Tetrazoles in Acidic Media
... 2-(1H-Tetrazole- 5-yl)-3-(4- hydroxyphenyl acrylonitrile) 1, 2-(1H-Tetrazole-5-yl)-3-(4-nitrophenylacrylonitrile)-2, and 2-(1H-Tetrazole-5-yl)-3-phenylacrylonitrile -3 were performed to ...
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MCM-41-SO3H as an efficient reusable nano-ordered heterogeneous catalyst for the synthesis of divers 1- & 5-substituted 1H-tetrazoles
... suer from drawbacks such as the use of a catalyst con- taining transition metals, harsh and stringent reaction conditions (e.g., volatile or highly corrosive solvents), metal and expensive catalase, longer reaction time, ...
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Heterogeneous Copper Nanoparticle on Charcoal (Cu/C) Mediated Efficient Synthesis of 1-Substituted 1H-Tetrazoles under Solvent Free Condition
... Tetrazoles are a group of nitrogenous heterocyclic compounds with a five-membered ring including one carbon and four nitrogen atoms, ...[1]. Tetrazoles have attracted considerable attention due to ...
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Benign synthesis of 5-substituted 1H-tetrazoles via [3+2] cycloaddition of nitriles and sodium azide employing SO3H-carbon as an efficient heterogeneous catalyst
... (Table 1, entry ...the substituted benzonitriles (1b–h) with sodium azide in order to obtain the corresponding tetrazole derivatives (2b–h) in good to excellent ...corresponding tetrazoles in ...
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Synthesis, Spectral, Theoretical, Antimicrobial Evaluation, and Molecular Docking Studies of Some Novel Ethyl 5 (1 Methyl 1h Tetrazol 5 Ylthio) 4 Oxo 2,6 Substituted Diphenylpiperidine 3 Carboxylate Derivatives
... [4,5]. Tetrazoles and their derivatives have been reported as antibacterial [6], antiviral [7], herbicidal [8], anti-inflammatory [9], antitumor [10], analgesic [11], and antiproliferative [12] ...
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AN IMPROVED AND CONVENIENT ROUTE FOR THE SYNTHESIS OF 5 METHYL 1H TETRAZOL 1 YL SUBSTITUTED BENZENAMINES
... The successive progress in medicinal chemistry continues to emphasize the need for convenient and efficient routes to spawn bioactive molecules. [1] Due to their high degree of atom economy, convergence and ...
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Electrochemical and Quantum Chemical Studies of 5 Substituted Tetrazoles as Corrosion Inhibitors for Copper in Aerated 0 5 M H2SO4 Solution
... As can been seen from Figure 2, both anodic and ca- thodic reactions of corrosion process were significantly inhibited while the tetrazole derivatives were added to the acid solution. The addition of the compounds ...
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Synthesis of 1,5 and 2,5-disubstituted tetrazoles using NiO nanoparticles and their evaluation as antimicrobial agents
... of tetrazoles is known as a highly main moiety in organic; organometallic; medicinal chemistry [1-6], and in diverse materials science including propellants [7], and inflammables [8], 1,5- and ...
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FeCl3 Catalyzed One Pot Synthesis of 1 Substituted 1H 1,2,3,4 Tetrazoles under Solvent Free Conditions
... of 1-substituted tetrazoles involve acid-catalyzed cycloaddition be- tween hydrazoic acid and isocyanides [5] or trimethylsilylazide [6], cyclization between primary amines with an ...
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Water Mediated One Pot Synthesis of pyrazolo[1,5-a] Pyrimidine Derivatives and their Antimicrobial Activity Dr. Jayesh Babariya 1, Dr. Yogesh T. Naliapara2
... The minimum inhibitory concentration (MIC) values of compounds (1-24) were determined by using the broth microdilution method with 96 micro test plate (Andrews, 2001). The samples were dissolved in DMSO at 1250 ...
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ABSTRACT : Certain organic compounds such as formic acid, acetic acid, substituted piperazine-1-carbonylchloride
... acid, substituted piperazine-1-carbonylchloride and 2-bromomethylbenzoate are reacted with compound 2-(5-fluoro-2-methyl-1H-inden-3-yl)acetohydrazide to form new ...
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An Efficient and Green Synthesis of 1, 5-Benzodiazepines
... Benzodiazepines are a class of agents that work on the central nervous system, acting selectively on gamma- aminobutyric acid-A (GABA-A) receptors in the brain. It enhances response to the inhibitory neurotransmitter ...
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Synthesis and biological evaluation of (4 substituted benzylidene) 3 methyl 1 (substituted phenyl sulfonyl and substituted benzoyl) 1H pyrazol 5(4H) one asanti inflammatory agent
... Melting points were taken in open capillary takes and are therefore uncorrected. Purity of the compound was checked on silica gel G TLC plates of 2 mm thickness using n-hexane and ethyl acetate as solvent system, The ...
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SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW [1-BENZYL-2- PHENYL-SUBSTITUTED]-1H-5, 6-SUBSTITUTED-BENZO (d) IMIDAZOLES DERIVATIVES
... IR, 1 H NMR and Mass Spectroscopic ...position 1 and 2 of benzimidazoles, considerably enhanced the activities when compared to the benzimidazoles having no substituents on the ...
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Coordination polymers of 5 substituted isophthalic acid
... Type 1 and one Type 2, in which the methyl groups of both layers are di- rected towards the centre of the ...and 5-methyl isophthalic acid, differing only in which or- ganic solvent is used in conjunction ...
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Synthesis and anticonvulsant activity of 1 [(4, 5 dihydro 5 phenyl 3 (phenylamino)pyrazol 1 yl)]ethanone derivatives
... These compounds obtained by convenient synthetic method in Ist step. The relatively simple structure and high affinity of chalcones towards colchicines binding site is because of similarity of the two-aryl group where ...
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1 [2 (Dicarboxymethyl) 3 oxocyclopent 4 en 1 yl]pyrrolidin 1 ium bromide hydrate
... of substituted cyclopentenes obtained from activated 2-substituted furan derivatives, we have reported the synthesis of (5-amino-sub- stituted-cyclopenten-3-en-1-yl)-4H-1,3-dioxin-4-ones ...
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Synthesis, antihelmintic and insilico evaluation of 5 (substituted styryl) 5 (benzylideneamino) 1, 2, 4 triazolidine 3 ones
... of 5-(substitutedstyryl)-5-(benzylideneamino) - 1, 2, 4-triazolidine-3-one derivatives were synthesized by condensation of oxazol-5-ones by reaction of hippuric acid and different aldehydes ...
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