Substrates for Protein Phosphatase 2A
Therapeutic relevance of the protein phosphatase 2A in cancer
... specific substrates of the Class I subunits and disrupting these substrate-specific interactions may be highly beneficial for sensitizing PLK1- overexpressing ...
18
FAM122A, a new endogenous inhibitor of protein phosphatase 2A
... PP2A-Cα protein by the ubiquitination The previous investigations showed that PP2A activity can be regulated by the alteration of protein expression of its subunits, post-translational modifications of ...
14
Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules
... (MT)-associated protein tau are major components of Alzheimer’s disease paired helical ...of protein phosphatase 2A (PP2A), is localized on MTs, binds directly to tau, and is a major tau ...
9
Biochemical and functional characterization of disease-associated aberrations in Protein Phosphatase 2A
... Aα protein (R183Q or R183G) instead of WT Aα were assayed in the presence of TIPRL1, a clear inhibition of PP2A activity could be observed ( Figure 10D,E ...suppresses phosphatase activity of specific PP2A ...
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Genetic Analysis of B55α/Cdc55 Protein Phosphatase 2A Subunits: Association with the Adenovirus E4orf4 Protein
... key substrates involved in mitotic and cell cycle pro- gression ...normal substrates, and the present studies are certainly consistent with this ...reduce phosphatase ac- ...␣ substrates in ...
10
B56δ related protein phosphatase 2A dysfunction identified in patients with intellectual disability
... Taken together, for all but one (P53S in PPP2R5D) of the de novo mutations identified, our biochemical data are consistent with a common defect in PP2A-B56δ–dependent dephosphorylation. A-C binding–defective B56δ ...
13
Adenovirus Protein E4orf4 Induces Premature APCCdc20 Activation in Saccharomyces cerevisiae by a Protein Phosphatase 2A-Dependent Mechanism
... We propose that E4orf4 may provide a unique tool for specific interrogation of the role that PP2A Cdc55 plays in the regulation of mitotic events and for identification of PP2A Cdc55 substrates. In the present ...
12
Protein Phosphatase 2A Enhances Activation of Human Immunodeficiency Virus Type 1 by Phorbol Myristate Acetate
... sponse elements than does PMA (19). This was supported by the minimal contribution of the B elements to the PP2A response seen upon direct testing (data not shown). This study demonstrates that the stimulation of HIV-1 ...
6
The Adenovirus E4orf4 Protein Induces G2/M Arrest and Cell Death by Blocking Protein Phosphatase 2A Activity Regulated by the B55 Subunit
... critical substrates, reduction of endoge- nous B55-B ␣ levels alone might be expected to induce similar ...␣ protein levels compared to a random shRNA se- ...
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Role of B Regulatory Subunits of Protein Phosphatase Type 2A in Myosin II Assembly Control in Dictyostelium discoideum
... the phosphatase activity to specific substrates or specific sub- cellular locations, thereby conferring specificity to the enzyme ...the phosphatase activity, either positively or negatively, in ...
7
Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase 1 in Tat activated HIV 1 transcription
... One of the major nuclear subunits of PP1 is Nuclear Inhibitor of PP1 (NIPP1) that binds to the catalytic subu- nit of PP1 and form an inactive holoenzyme complex which can be activated by phosphorylation of NIPP1 ...
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Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Chronic Myeloid Leukaemia
... The observed reduction in CIP2A levels is very promising when considered clinically. Ponatinib is already proving effective in the combat of BCR-ABL1, T315I and other BCR-ABL1 mutants; these results would tentatively ...
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The role of Protein Phosphatase 2A (PP2A) in myocardial ischaemia/reperfusion injury
... A decade after the first descriptions of PTPA, Fellner et al. (2003) made the observation, using yeast homologs of PTPA, that it is not only involved in the activation of a PTP activity in PP2A, but it is actually also ...
355
PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B
... between protein kinases and phosphatases has been well recognized as the direct cause for the AD-like tau hyperphosphorylation [3] ...tau phosphatase activities and can dephosphory- late tau isolated from ...
9
Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer
... key phosphatase, protein phosphatase 2A (PP2A), and its regulatory role in inflammatory and tumour suppression in both disease settings suggests that it may be critical in the progression of ...
18
Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice
... revealed that proteinuria results from defects in the actin cytoskeleton, the slit diaphragm, the glomerular base- ment membrane, and podocyte loss. Interestingly in present study, deletion of PP2A in podocytes leads to ...
12
Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase.
... Furthermore, we detected protein kinase activity in PP2A immunoprecipitates and protein phosphatase activity in src immune complexes from extracts of middle T-antigen-transformed, but no[r] ...
10
TORC2 Signaling Is Antagonized by Protein Phosphatase 2A and the Far Complex in Saccharomyces cerevisiae
... Lst8 interacts with the kinase domain of Tor2 in yeast TORC2 (Wullschleger et al. 2005). Since far11D bypasses lst8D and tor2-21, but not tor2D, avo1D, and avo3D, our data suggest that neither lst8D nor the ...
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A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
... plasticity. Protein kinases and protein phos- phatases are important players in the induction of both long-term potentiation (LTP) and long-term depression ...
12
Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila
... ABSTRACT Protein phosphatase type 2A complex (PP2A) has been known as a tumor suppressor for over two decades, but it remains unclear exactly how it suppresses tumor ...E protein levels, ...
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