Suicide gene therapy
Prodrug activating systems in suicide gene therapy
... in suicide gene therapy to date have been clinical- ly licensed anticancer agents with known pharmaco- logical, pharmacokinetic, dosage, and safety ...
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Purification and characterization of Aspergillus parasiticus cytosine deaminase for possible deployment in suicide gene therapy
... Cytosine deaminase is employed in the so-called sui- cide gene therapy to treat tumours. Currently, the CD used in this therapy are either from bacterial or yeast sources. The enzyme from either of ...
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In vitro and in vivo double enhanced suicide gene therapy mediated by generation 5 polyamidoamine dendrimers for PC 3 cell line
... that suicide gene therapy is the focus of the cancer gene therapy research because of its “ bystander effect ” ...the suicide gene can result in widespread tumor cell ...
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An Enterovirus-Like RNA Construct for Colon Cancer Suicide Gene Therapy
... In gene therapy, the use of RNA molecules as therapeutic agents has shown advantages over plasmid DNA, including higher levels of ...reporter gene (enhanced green fluorescent protein) and a ...
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T-cell suicide gene therapy in the management of graft versus host disease following allogeneic bone marrow transplatation
... cell suicide gene therapy used amphotropic virus supernatant-based gene transfer protocols (Tiberghien et al, ...Neo^ gene co-expression and the transduction procedure required 12 days ...
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STAT3/NF-κB-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer
... cancer. Suicide gene therapy has been used for the in vivo treatment of various solid tumors in recent clinical ...STAT3-NF-κB-TK/GCV suicide gene therapy ...
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Fiber-modified adenovirus-mediated suicide gene therapy can efficiently eliminate bladder cancer cells in vitro and in vivo
... In our previous studies, we constructed a recombinant oncolytic adenovirus Ad-UPII-E1A that targeted bladder cancer cells for E1A expression under the control of the UPII promotor [16, 17]. The oncolytic effects of ...
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<p>GADD45α-targeted suicide gene therapy driven by synthetic CArG promoter E9NS sensitizes NSCLC cells to cisplatin, resveratrol, and radiation regardless of p53 status</p>
... with suicide gene therapy vector ...upon gene therapy treatment, while the levels of cleaved caspase-3 and cleaved PARP were increased (Figure ...our suicide gene ...
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Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma
... downstream suicide gene, herpes simplex virus thymidine kinase (HSVtk) for hepatocellular car- cinoma (HCC) gene ...therapeutic gene (HSVtk) was expressed inside tumor and how effectively a ...
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Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suicide gene therapy to fight malignant glioma
... Tumor necrosis factor-related apoptosis-inducing lig- and (TRAIL) is a highly potent therapeutic agent that has been shown to significantly increase the apoptosis as well as decrease the migration capacity of GBM cells ...
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Gene therapy with tumor specific promoter mediated suicide gene plus IL 12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma
... of suicide gene therapy, it is important to explore new strategies of combined therapy, which employ targeted suicide gene in combination with immunotherapy that cooperatively ...
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The human somatostatin receptor type 2 as an imaging and suicide reporter gene for pluripotent stem cell-derived therapy of myocardial infarction
... Rationale: Pluripotent stem cells (PSCs) are being investigated as a cell source for regenerative medicine since they provide an infinitive pool of cells that are able to differentiate towards every cell type of the ...
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Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicity
... the suicide gene, maximizing the potential for therapeutic ...of therapy-related ...combined suicide gene therapy with dexamethasone or radiation, both known immu- nomodulators ...
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Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach
... the suicide gene therapy field is that the initial, limited intratumoral killing of both stem cells and tumor cells, caused by injection of the stem cells and the inhos- pitable tumor ...
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GENE THERAPY OF CANCEROUS DISEASES
... Suicide gene therapy is based on introducing viral or bacterial genes to tumor cells, which allows the conversion of a non-toxic compound to a lethal ...many suicide systems described, the ...
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Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics
... prodrug-suicide gene therapy modality as applied for cancer therapeutics holds the potential to kill the tumour cells while triggering no collateral impairment to healthy cells [1, ...(HSV-TK) ...
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Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas
... conventional suicide gene therapy, stem cell-mediated suicide gene therapy can ablate therapeutic stem cells after treatment with ...combination therapy with neural stem ...
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DNA as therapeutics; an update
... Human gene therapy is the introduction of new genetic material into the cells of an individual with the intention of producing a therapeutic benefi t for the ...in gene therapy. Over time and ...
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Prinz, Christoph (2018): Biopharmaceutical characterization of porcine mesenchymal stromal cells as a model system for a human cell therapy product. Dissertation, LMU München: Medizinische Fakultät
... The transduction process itself is influenced by many variables. Although the same batch of vector supernatant was used, all cell transductions were performed on different days after isolation from the tissue due to the ...
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When Death Seems Suddenly Appealing, Defeated by the Long, Hard Struggle to Stay Alive
... attempting suicide needs to be provided immediate emergency mental health services, and arrangements need to be made for providing consistent emotional and psychological and psychiatric support for the next few ...
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