SURFACTANT PROTEIN A
A novel nanobody specific for respiratory surfactant protein A has potential for lung targeting
... Pulmonary surfactant protein A (SPA) is predominantly synthesized by type II alveolar epithelial cells, and may serve as a potential lung-targeting ...
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The Porcine Pulmonary Surfactant Protein A (pSP A) Immunogenicity Evaluation in the Murine Model
... produce surfactant protein A, SP-A. This protein belongs to a group of soluble humoral pat- tern recognition receptors, called collectins, which mod- ulate the immune response to microorganisms ...
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Surfactant protein A enhances respiratory syncytial virus clearance in vivo
... Surfactant protein-A (SP-A) is a 28- to 34-kDa member of the collectin subgroup of the mammalian C-type lectins that also includes surfactant protein-D (SP-D), mannose-binding protein, ...
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Generation of lyso phospholipids from surfactant in acute lung injury is mediated by type II phospholipase A2 and inhibited by a direct surfactant protein A phospholipase A2 protein interaction
... that surfactant is a major lung target of ...hydrolyze surfactant phospholipids in ...by surfactant protein A (SP-A) through a direct and selective protein–protein inter- action ...
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The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
... volunteers. Surfactant protein (SP)-A, SP-D, and Krebs von den Lungen-6 (KL-6) levels in serum and pulmonary function tests were also evaluated in IPF ...
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Cholesterol-Mediated Dysfunction of Surfactant Effects of Surfactant Protein-A and Diet-Induced Hypercholesterolemia
... dysfunctional surfactant (Gregory et ...the surfactant associated proteins and the presence of inhibitory agents (Cockshutt et ...serum protein in the lungs which can occur as a result of pulmonary ...
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Assessment of Surfactant Protein A (SP-A) dependent agglutination
... extensive protein networks when it interacts with phospholipid mono- layers [22], possibly preventing collapse of the surfactant lipid films in the presence of protein inhibitors, as they occur in ...
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On the significance of Surfactant Protein-A within the human lungs
... Since SP-A represents a central molecule in pulmonary immunoregulation as well as in host-defense it is obvious that defects in the surfactant system may have functional influence in the course of these pulmonary ...
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120 kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A
... internalized or degraded by the P. carinii organism. Furthermore, SP-A binding to P. carinii is time- and calcium-dependent and is competitively inhibited by mannosyl albumin. In the absence of calcium or the presence of ...
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Interactions of surfactant protein D with bacterial lipopolysaccharides Surfactant protein D is an Escherichia coli binding protein in bronchoalveolar lavage
... collagenous C-type lectins, including serum conglutinin, serum mannose-binding proteins, and surfactant protein A. Preliminary studies showed calcium- and saccharide-dependent binding of ...
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Plasma surfactant Protein-D levels in healthy subjects and COPD patients
... Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot ...of surfactant protein D ...associated surfactant protein A and D: ...
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Population-Based Estimates of Surfactant Protein B Deficiency
... of surfactant protein B, one of us ...of surfactant pro- teins A, B, and proSP-C in lung tissue from all 14 available ...detectable surfactant protein B, had increased staining for ...
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Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction
... of surfactant protein A (SP-A), sur- factant protein D (SP-D), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloprotei- nase-1 (TIMP-1) in young and middle aged/elderly smo- ...
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The Effects of NaCl, CaCl2, Lactose and pH on the Foaming Properties of Whey Proteins
... interfacial adsorption to protein structure (Mackie et al., 1999). These variants differ by only two amino acids, but the B variant was shown to adsorb more rapidly via surface tension measurements. The valine (A) ...
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EMC3 coordinates surfactant protein and lipid homeostasis required for respiration
... of surfactant proteins and lipids required for adaptation to air ...the surfactant-associated proteins and lipids, rendering them sen- sitive to alterations in surfactant homeostasis that cause ER ...
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Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
... SP-D is synthesized in type II pneumocytes and Clara cells. It is composed of monomers (43 kDa), which assemble into trimers via disulfid crosslinking and undergo further multimerization to higher order such as ...
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Metachronous adenocarcinoma of lung mimicking metastatic papillary thyroid carcinoma: A case report
... The mixed patterns of lepidic and papillary subtypes which are positive for surfactant protein SP-A, Napsin A and negative for thyroglobulin are concordant with the cytological impres[r] ...
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Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study
... regulating surfactant homeostasis in the lungs by modulating surfactant ultra- structure and promoting reuptake of surfactant by type II pneumocytes ...
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Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect
... and surfactant protein ...and surfactant homeostasis dis- ruption (focal alveolar septal fibrosis, alveolar type II cell hypertrophy and clusters of alveolar macrophages) ...
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MOLECULAR DOCKING AND MUTATIONAL STUDIES OF HUMAN SURFACTANT PROTEIN –D
... wild protein (2GGU) and with the mutant protein molecules (F335G and R343V) among all the lipid molecules distearoylphosphatidylcholine is showing highest docking score with all the three protein ...
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