surfactant protein-B
Population-Based Estimates of Surfactant Protein B Deficiency
... Conclusions. The close approximation of these inde- pendent estimates suggests accurate gene frequency (ap- proximately one 121ins2 mutation per 1000 –3000 individ- uals) despite its rare occurrence and that this ...
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Original Article Surfactant protein B gene polymorphisms is associated with risk of bronchopulmonary dysplasia in Chinese Han population
... between Surfactant protein B (SP-B) gene polymorphisms and bronchopulmonary dysplasia (BPD) development in preterm infants of China Han ethnic ...
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Original Article Surfactant protein B deficiency and gene mutations for neonatal respiratory distress syndrome in China Han ethnic population
... mature Surfactant protein B was found in both lung tissue and bronchoalveolar lavage fluid in 8 ...mature Surfactant protein B in both lung tissue and bronchoalveolar lavage ...
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Environmental pollutant ozone causes damage to lung surfactant protein B, SP B
... of surfactant material to prevent alveolar ...the surfactant material at the interface varies between species but contains mainly lipids, ∼ 90% by weight, and two hydrophobic proteins, surfactant ...
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Disaturated-phosphatidylcholine and Surfactant protein-B turnover in human acute lung injury and in control patients
... Surfactant Protein B (SP-B) is a small hydrophobic pro- tein synthesized as a preprotein (pro-SP-B) and pro- cessed to mature form en route from the Golgi complex to the lamellar bodies ...
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Fetal and neonatal samples of a precursor surfactant protein B inversely related to gestational age
... lung-specific protein, so SP-B in amniotic fluid is believed to come directly from the alveolar space, whereas SP-B in blood is thought to have permeated into the circulation from the alveolar ...
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A Combination of Short and Simple Surfactant Protein B and C Analogues as a New Synthetic Surfactant: In Vitro and Animal Experiments
... 4. Soll R, Ozek E. Multiple versus single doses of exogenous surfac- tant for the prevention or treatment of neonatal respiratory dis- tress syndrome. Cochrane Database Syst Rev 2009;(1):CD000141. 5. Kim SM, Park YJ, ...
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A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds
... homozygous for this mutation, which segregated in a fashion consistent with autosomal recessive inheritance of disease. The same mutation was found in two other unrelated infants who died from alveolar proteinosis, one ...
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Environmental pollutant ozone causes damage to lung surfactant protein B, SP B
... length protein SP-‐B has not yet been reported but circular dichroism and FTIR experiments reveal about 40-‐50% alpha-‐helical content when in micelles and lipid ...
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Original Article The relationship between single nucleotide polymorphisms of pulmonary surfactant protein B gene and respiratory distress syndrome in premature infants
... Ninety-two NRDS preterm infants admitted to the Affiliated Hospital of Hebei University from March 2017 to March 2018 were selected as the NRDS group. The inclusion criteria consist- ed of (A) premature infants who met ...
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Partial Deficiency of Surfactant Protein B in an Infant With Chronic Lung Disease
... Postmortem lung tissue contained normal levels of SP-A and its mRNA, a low but detectable level of SP-B, and near.. normal content of SP-B mRNA.[r] ...
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Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect
... of surfactant homeostasis are a rare cause of respiratory failure in newborns and infants ...encoding surfactant protein-B (SP-B) [2,3] and ABCA3, which encodes ATP-binding cassette ...
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Pulmonary Alveolar Proteinosis: A Comprehensive Clinical Perspective
... The label PAP is merely an overall description of alveolar filling with surfactant. It is very important to classify all cases definitively according to etiology and on the basis of new knowledge generated by ...
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A Review on Preparation and Evaluation of Nanoemulsions
... varies from 10 to 1,000 nm. These carriers are solid spheres and their surface is amorphous and lipophilic with a negative charge. The term ‘nanoemulsion’ also refers to a mini emulsion which is fine oil/water or ...
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Neglected evidence in idiopathic pulmonary fibrosis and the importance of early diagnosis and treatment
... FIGURE 1 Telomere length and telomerase mutations in a) familial and b) sporadic idiopathic pulmonary fibrosis. SP: surfactant protein; TERT : telomerase reverse transcriptase; TERC: tel[r] ...
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On the significance of Surfactant Protein-A within the human lungs
... [2]. Surfactant is a complex mixture of lipids, carbohydrates and four proteins (SP-A, SP-B, SP-C, ...of surfactant lead back to the 1950s, but little attention was given to the surfactant ...
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Surfactant Protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
... Supernatants were taken after 8 hours incubation with unlabelled SPP and further 72 hour incubation with CD4 + -T-cells in fresh medium. All cytokines and che- mokines were measured by bead-based protein quantifi- ...
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Pulmonary Alveolar Proteinosis: A Comprehensive Clinical Perspective
... treatment with WLL in those patients was only transiently effective, reducing the need for oxygen and improving imaging. The amount of protein recovered was low, which also differentiated this form of PAP from the ...
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Rituximab for auto-immune alveolar proteinosis, a real life cohort study
... Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by deposition of extracellular lipoprotei- naceous material within pulmonary alveoli [1]. PAP usually results from failure of clearance of ...
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The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
... volunteers. Surfactant protein (SP)-A, SP-D, and Krebs von den Lungen-6 (KL-6) levels in serum and pulmonary function tests were also evaluated in IPF ...
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