SURFACTANT PROTEIN D
Plasma surfactant Protein-D levels in healthy subjects and COPD patients
... Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot ...of surfactant protein D ...associated surfactant ...
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MOLECULAR DOCKING AND MUTATIONAL STUDIES OF HUMAN SURFACTANT PROTEIN –D
... space surfactant proteins plays active role in the defense mechanism among all the surfactant proteins, Surfactant protein-D (SP-D) plays a crucial role in the host defense and ...
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Surfactant protein-D and pulmonary host defense
... Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the ...specific ...
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Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease
... (Surfactant protein D (SP-D), Club cell protein 16 (CC-16), and Pulmonary and activation-regulated chemokine (PARC/CCL-18)) and systemic inflammatory biomarkers (C-reactive ...
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Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study
... circulating surfactant protein D (SPD) or Clara Cell protein-16 (CC16) levels are associated with lung function or health status in patients with severe ...
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Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages
... gpA. Surfactant protein D (SP-D) is a recently described component of the airspace lining material that possesses a calcium- dependent lectin domain capable of interacting with glycoconjugates ...
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Value of serum and induced sputum surfactant protein-D in chronic obstructive pulmonary disease
... The statistical analyses of our study were performed using SPSS statistical software version 15.0. The variables were investigated using visual (histograms, probability plots) and analytical methods (Kolmogorov-Simirnov ...
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The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia
... A number of pulmonary pathogens, including Streptococ- cus pneumoniae, have been reported to be agglutinated by lung surfactant protein D in vitro [10-13]. In one such study using SP-D ...
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Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D
... In inflammatory lung diseases, airway epithelial cells act as important immunomodulators [10] and by interac- tion with inhaled allergen, they may play an essential role in allergic asthma [11]. Thereby, epithelial cells ...
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Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D
... [3-6]. Surfactant protein D (SP-D) has particularly important roles in restricting IAV replication and limiting the severity of inflammatory responses during the first several days of ...
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Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D
... Surfactant protein-D (SP-D), a pattern-recognition mole- cule of the pulmonary innate immune system, enhances the phagocytosis and clearance of various inhaled patho- gens, allergens, and ...
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Interactions of surfactant protein D with bacterial lipopolysaccharides Surfactant protein D is an Escherichia coli binding protein in bronchoalveolar lavage
... collagenous C-type lectins, including serum conglutinin, serum mannose-binding proteins, and surfactant protein A. Preliminary studies showed calcium- and saccharide-dependent binding of ...
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Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D
... of protein required to fully inhibit the hemaggluti- nating activity of the viral suspension was determined by noting the highest dilution of protein that still inhibited ...highest protein ...
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Surfactant Protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
... junction protein in MDM and MDDC which was suggested to preserve the epithelial integrity in a trans-epithelial network maintained by both immune cells in order to capture and translocate inhaled particulate ...
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Surfactant protein D modulates HIV infection of both T cells and dendritic cells
... particles (Figure 1D) and what has been observed for whole SP-D molecules and hexoses [46]. This was confirmed by the finding that SP-D has a stronger affinity for gp120 than seen for MBL (Figure 3D) which ...
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Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease
... SP-D protein in the lungs. Furthermore over-expression of SP-D in A549 cells was found to increase survival in vitro after exposure to 4% cigarette smoke ...SP-D protein quantification ...
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Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β
... In either chronic antigen exposure asthma model or gene-modified model, both peribronchial fibrosis and TGF-β production were related to eosinophils [26,27]. In airways of asthmatic patients, 75-80% of TGF-β1 mRNA ...
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Circulating surfactant protein D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis
... In order to further elucidate the possible role of SP-D in joint inflammation, we quantified SP-D in paired serum and synovial samples and studied the molecular size distri- bution in serum and synovial ...
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Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study
... tails and globular lectin heads containing C-type carbohy- drate recognition domains. Produced in alveolar type-II cells and Clara cells, SP-D is a 43-kD monomer that forms a higher order quaternary structure ...
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Surfactant protein-D (SP-D) gene polymorphisms and serum level as predictors of susceptibility and prognosis of acute kidney injury in the Chinese population
... SP-D protein thereby impacting on its function [10]. Further- more, SP-D protein posttranslational modifications such as nitrosylation of multimeric SP-D could cause collagen tail ...
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