Surfactant protein D (SFTPD)
MOLECULAR DOCKING AND MUTATIONAL STUDIES OF HUMAN SURFACTANT PROTEIN –D
... space surfactant proteins plays active role in the defense mechanism among all the surfactant proteins, Surfactant protein-D (SP-D) plays a crucial role in the host defense and ...
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Plasma surfactant Protein-D levels in healthy subjects and COPD patients
... Methods: The comparative study was conducted at the University of Health Sciences, Lahore, Pakistan, from January to December 2015, and comprised chronic obstructive pulmonary disease patients and healthy smokers of ...
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Surfactant protein-D and pulmonary host defense
... Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the ...specific ...
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Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease
... (Surfactant protein D (SP-D), Club cell protein 16 (CC-16), and Pulmonary and activation-regulated chemokine (PARC/CCL-18)) and systemic inflammatory biomarkers (C-reactive ...
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Value of serum and induced sputum surfactant protein-D in chronic obstructive pulmonary disease
... The statistical analyses of our study were performed using SPSS statistical software version 15.0. The variables were investigated using visual (histograms, probability plots) and analytical methods (Kolmogorov-Simirnov ...
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Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study
... C-reactive protein, CRP) correlate with disease severity and with adverse health outcomes of patients with mild to moderate disease ...desirable. Surfactant protein D (SPD) and Clara cell pro- ...
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Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D
... Surfactant protein-D (SP-D), a pattern-recognition mole- cule of the pulmonary innate immune system, enhances the phagocytosis and clearance of various inhaled patho- gens, allergens, and ...
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Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D
... [3-6]. Surfactant protein D (SP-D) has particularly important roles in restricting IAV replication and limiting the severity of inflammatory responses during the first several days of ...
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Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages
... gpA. Surfactant protein D (SP-D) is a recently described component of the airspace lining material that possesses a calcium- dependent lectin domain capable of interacting with glycoconjugates ...
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Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium
... SP- D TaqMan assay probe (Hs00358340_m1 SFTPD) or hypoxanthine phosphoribosyltransferase (HPRT) Taq- Man assay probe (Hs99999909_m1HPRT1) in 384-well ...
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Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients
... Our data are, at least in part, in line with results from a previous study. In a sub-analysis of the ARDS Net- work trial comparing lower tidal volumes with conven- tional tidal volumes systemic levels of SP-D ...
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Surfactant protein D modulates HIV infection of both T cells and dendritic cells
... recombinant protein CVN neutralises HIV by targeting a specific mannose-dependent epitope on gp120 [43] the observa- tion here with the differential results shows that the SP-D and CVN proteins probably ...
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Interactions of surfactant protein D with bacterial lipopolysaccharides Surfactant protein D is an Escherichia coli binding protein in bronchoalveolar lavage
... several strains of enteric Gram-negative bacteria. Immunogold studies demonstrated strong and uniform surface labeling of the bacteria. Rat and human bronchoalveolar lavage (BAL) caused Ca(++)-dependent agglutination of ...
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Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D
... Table 2 shows concentrations of SP-D needed to inhibit chronologically listed H3N2, H1N1, and H5N1 IAV strains. The table also shows the sites of N-linked glyco- sylation on the HA "head" of these strains. ...
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Surfactant Protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
... (collagen containing lectins) and is built of 12 mono- mers (43 kDa) each consisting of a N-terminal region, a collagen-like domain, a neck region and a globular head carbohydrate recognition domain (CRD) [7]. Three of ...
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Evidence for a protective role of pulmonary surfactant protein D (SP D) against influenza A viruses
... viruses (IAVs). SP-D potently inhibited hemagglutination activity of several strains of IAV as well as causing viral aggregation. SP-D enhanced neutrophil binding of IAV and neutrophil respiratory burst ...
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Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
... SP-D is synthesized in type II pneumocytes and Clara cells. It is composed of monomers (43 kDa), which assemble into trimers via disulfid crosslinking and undergo further multimerization to higher order such as ...
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No effect of ablation of surfactant protein-D on acute cerebral infarction in mice
... SP-D KO mice at day five indicates that SP-D modu- lates the microglial-macrophage TNF response to is- chemia in WT mice in the late phase after induction of ischemia. SP-D is known to bind TLR2 and ...
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The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D
... [4], surfactant protein (SP)-A and SP-D [5,6], matrix metalloproteinase (MMP)1 and MMP7 [7], brain natriuretic peptide [8], and, most recently CC- chemokine ligand 18 [9] are elevated in patients ...
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Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis
... Results: The most prevalent lung phyla were Firmicutes, Proteobacteria and Bacteroidetes. Decreased microbial diversity was found in patients with low forced vital capacity (FVC) and early mortality. Additionally, the ...
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