Surgical randomised controlled trial
Ankle Injury Management (AIM): design of a pragmatic multi centre equivalence randomised controlled trial comparing Close Contact Casting (CCC) to Open surgical Reduction and Internal Fixation (ORIF) in the treatment of unstable ankle fractures in patients over 60 years
... This is a pragmatic study. We will monitor and analyse data to establish the extent, if any, of learning or expertise effects. It is common practice that surgeons have particu- lar expertise in selected techniques, and ...
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The effect of triclosan coated sutures on rate of Surgical Site Infection after hip and knee replacement: a protocol for a double blind randomised controlled trial
... this trial is the ease with which the intervention could be applied pragmatically into any NHS ...pragmatic trial with an appropriate sample size calculation, double blind, with clearly defined inclusion ...
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Ankle injury management (AIM) : design of a pragmatic multi centre equivalence randomised controlled trial comparing close contact casting (CCC) to open surgical reduction and internal fixation (ORIF) in the treatment of unstable ankle fractures in patients over 60 years
... Methods/Design: This study is a pragmatic multi-centre equivalence randomised controlled trial. 620 participants will be randomised to receive ORIF or CCC after sustaining an isolated ...
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The effect of triclosan coated sutures on rate of Surgical Site Infection after hip and knee replacement : a protocol for a double blind randomised controlled trial
... superficial surgical site infection at 30 ...deep surgical site infection at 12 months, length of hospital stay, critical care stay, and payer ...orthopaedic randomised controlled trials on ...
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Randomised Ambulatory Management of Primary Pneumothorax (RAMPP): protocol of an open-label, randomised controlled trial
... The primary outcome measure will be total length of stay in hospital to include primary hospital stay and readmissions up to 30 days postrandomisation. Patients remaining in hospital overnight will be classed as 1 day; ...
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Interventions in randomised controlled trials in surgery: issues to consider during trial design
... a surgical operation, anaesthetic and aftercare should be described in the trial protocol is ...each trial group, ensuring that they are actually different from one ...similar surgical ...
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Surgical treatment versus expectant care in the management of incomplete miscarriage: a randomised controlled trial
... unnecessary surgical interventions while maintaining low morbidity and mortality and is considered suitable for women with no maternal anaemia and RPC which has an AP diameter of 15 mm-50 mm on TVS [1-4, ...
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Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial
... A computer-generated random number table was used to randomise a consecutive sequence of numbers into two groups — intervention and control — in permuted blocks of 20 with a 1:1 ratio. These numbers were used to label ...
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Protocol for Physiotherapy OR Tvt Randomised Efficacy Trial (PORTRET): a multicentre randomised controlled trial to assess the cost-effectiveness of the tension free vaginal tape versus pelvic floor muscle training in women with symptomatic moderate to severe stress urinary incontinence
... invasive surgical procedure, the Tension-free Vaginal Tape (TVT) has rapidly become the gold standard in surgical treatment of stress urinary ...a randomised clinical ...
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Minimally invasive non surgical vs surgical approach for periodontal intrabony defects: a randomised controlled trial
... Methods: This is a parallel-group, single-centre, examiner-blind non-inferiority randomised controlled trial with a sample size of 66 patients. Inclusion criteria are age 25 – 70, diagnosis of ...
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CASINO: Surgical or Nonsurgical Treatment for cervical radiculopathy, a randomised controlled trial
... the trial and are also responsible for the implementation of the trial data management using ProMISe software, WA and BKo are co-designers of the protocol and deliver input from a general practitioners ’ ...
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Protocol for the ProFHER (PROximal Fracture of the Humerus: Evaluation by Randomisation) trial: a pragmatic multi centre randomised controlled trial of surgical versus non surgical treatment for proximal fracture of the humerus in adults
... part surgical neck fractures (28% of the whole population), followed by 3 part greater tuberosity and surgical neck fractures ...domised controlled trials (RCTs) to inform management decisions for ...
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Negative pressure wound therapy versus usual care for Surgical Wounds Healing by Secondary Intention (SWHSI trial): study protocol for a randomised controlled pilot trial
... intention). Surgical Wounds Healing by Secondary Intention (SWHSI) are often more complex to manage, and require additional treatments during the course of ...Previous randomised controlled trials ...
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Varied flushing frequency and volume to prevent peripheral intravenous catheter failure: a pilot, factorial randomised controlled trial in adult medical surgical hospital patients
... The small pilot sample and single site setting impact on the interpretation and generalisability of the results. It was not possible to mask the respective interventions, and so there was potential for outcome assessment ...
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‘The trial is owned by the team, not by an individual’: a qualitative study exploring the role of teamwork in recruitment to randomised controlled trials in surgical oncology
... This study has explored the importance of teamwork in recruitment to a multicentre study in upper gastro- intestinal cancer involving treatments delivered by dif- ferent clinical specialties. The importance of the weekly ...
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Therapeutic options for chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review
... eight randomised controlled studies included (Tau 2 = ...clinical trial is underway to observe whether alpha lipoic acid, an antioxidant with anti- inflammatory properties may prove effective to ...
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Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness
... Venous blood was taken on admission for immediate measurement of haemoglobin (Hb), blood glucose, lac- tate, malaria parasitaemia, and HIV status. Hb was mea- sured using the HaemoCue Hb 301 system (HaemoCue AB, ...
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Strengthening and stretching for rheumatoid arthritis of the hand (SARAH) : design of a randomised controlled trial of a hand and upper limb exercise intervention ISRCTN89936343
... For the within-trial analysis, costs incurred and Quality-Adjusted Life Years (QALYs) attained over the twelve month study period will be estimated at the indi- vidual patient level. The EuroQol (EQ-5D) will be ...
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How can we improve stroke thrombolysis rates? A review of health system factors and approaches associated with thrombolysis administration rates in acute stroke care
... 90:10” trial found an 11 % relative improvement in some aspects of initial assessment and care for stroke patients following collaborative quality improvement ...
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Effect of herbal extract granules combined with otilonium bromide on irritable bowel syndrome with diarrhoea: a study protocol for a randomised controlled trial
... If the Subject’s Global Assessment of Relief on the Likert scale is ‘0’ or ‘1’ for more than 2 weeks between weeks 8 and 12, then the symptoms will be considered to have improved sufficiently. Based on this, we will ...
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