Surrogate markers
Validation of a Newly Developed Equation for Estimating Serum Apolipoprotein B: Associations with Cardiovascular Disease Surrogate Markers in Koreans
... CV surrogate markers in order to validate a previously reported apoBE ...gate markers. apoBE had a stronger association with CV sur- rogate markers than estimated or directly-measured ...CV ...
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Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes
... under receiver operating curves (AUC) were calculated and the cut-off values of the vascular assessments with optimal sensitivity and specificity were obtained. These cut-off values were then used in subsequent analysis ...
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Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study
... Several reasons may explain why pivotal trials could have larger treatment effects based on surrogate markers compared with postapproval trials. First, pivotal trials may have more stringent inclusion ...
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Using surrogate markers in primary electronic patient record systems to confirm or refute the diagnosis of diabetes
... The use of plasma glucose levels alone as a non- diagnostic marker to identify diabetic patients was specific and had a high predictive value. The use of plasma glucose levels greater than 7.0 mmol/l (11.1 mmol/l as per ...
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Laboratory Surrogate Markers of Residual HIV Replication among Distinct Groups of Individuals under Antiretroviral Therapy
... We recognize that the retrospective cross-sectional nature of this study may preclude more definite conclusions. The evaluation of only one time point in this group prevents us from understanding the dynamics of these ...
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Development of an algorithm of haematologic parameters as surrogate markers for CD4 cell count in resource-limited settings
... Few studies have been done suggesting the use of different multiple parameters as surrogate markers for the CD4 count. The primary benefit of using these parameters in an algorithm is to increase the ...
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Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis
... for surrogate markers of death using modified versions of the MSS, M-CASS, and MGS scoring systems until 24 h post-operatively, or until endpoint (inability to ambulate) and consequent ...effective ...
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Protein and DNA methylation based scores as surrogate markers for interferon system activation in patients with primary Sjögren’s syndrome
... surface markers have been suggested as surrogate markers for IFN activity in systemic autoimmune diseases or interferonopa- thies such as galectin-9, 41 SIGLEC1, 42 MxA, 43 CXCL10 40 and ...
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Independent associations of total and high molecular weight adiponectin with cardiometabolic risk and surrogate markers of enhanced early atherogenesis in black and white patients with rheumatoid arthritis: a cross sectional study
... Patients with RA experience substantially increased risk for cardiovascular disease [67-72]. Over the recent past, paradoxical positive relations between adiponectin concentrations and cardiovascular risk were reported ...
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Cytokines, Plasma Immune Activation Markers, and Clinically Relevant Surrogate Markers in Human Immunodeficiency Virus Infection
... gate markers or combinations add to prognostic capability (and how far from perfect each is) ...that surrogate markers do ad- vance prognostic capability, the precision of prediction (POP) method ...
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Effects of Pitavastatin on the Intima Media Thickness of the Carotid Artery in Patients with Ischemic Stroke: The Pitavastatin Efficacy Study on Surrogate Markers and Imaging for Stroke (PESSMIST)
... lected surrogate markers as the primary ...gate markers of the risk of stroke [4] [21]. Therefore, these surrogate markers were selected as the end-points in this study, and might also ...
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MODELING OF HIV/AIDS SURVIVAL AND STAGING USING SURROGATE MARKERS
... immunologic surrogate markers such as plasma HIV RNA copies (viral load) and CD4+ cell counts play important roles in survival, staging and evaluating therapies in AIDS clinical ...
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Serial counts of Mycobacterium tuberculosis in sputum as surrogate markers of the sterilising activity of rifampicin and pyrazinamide in treating pulmonary tuberculosis
... treatment. Surrogate markers for relapse are therefore required to obtain a preliminary indication of efficacy and sterilising activity of the drug, even though a phase III trial with estimation of relapse ...
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<p>Usefulness Of Surrogate Markers Of Body Fat Distribution For Predicting Metabolic Syndrome In Middle-Aged And Older Korean Populations</p>
... Two strengths of this study are that it had a relatively large sample and that it compared the predictive powers of four obesity markers for MetS. However, this study has a few limitations. First, because of the ...
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Phenotypic changes on Mycobacterium tuberculosis specific CD4 T cells as surrogate markers for tuberculosis treatment efficacy
... activation markers observed upon treatment initiation contrasted with the minor changes observed for the maturation marker ...of markers are most informative on treatment and disease/infection ...activation ...
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A tool for evaluating the potential for cost-effective outcomes measurement
... using surrogate markers to identify patients at high risk of cardiovascular events who may benefit from intensive ...use surrogate markers to identify patients at high risk of cardio- vascular ...
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The potential role of three-dimensional surface imaging as a tool to evaluate aesthetic outcome after Breast Conserving Therapy (BCT)
... Three-dimensional surface imaging (3D-SI) has been used as a marketing tool in aesthetic breast surgery. Three- dimensional (3D) images are taken and manipulated to illustrate to potential patients how they may appear ...
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“Black Tea Consumption Enhance Antioxidant Status, Reduce Inflammatory Stress vis-a-vis Insulin resistance: Hint from a Small Clinical Cohort Study on Pre-diabetic Subjects” by Sirshendu Chatterjee, Nirmalya Roy, Arpita Saha, Surmi Roy, Ananya Chatterjee, Nandita Hazra, Soma Lahiri, Chittaranjan Maity, Sandip K. Bandyopadhyay, India.
... on surrogate markers of insulin resistance such as serum total antioxidant status, lipid peroxidation, pro and anti inflammatory cytokine ...reducing surrogate markers of insulin resistance ...
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Metabolomics enables precision medicine: "A White Paper, Community Perspective"
... and surrogate markers of diverse disease states; (2) inform on underlying molecular mechanisms of diseases; (3) allow for sub-clas- sification of diseases, and stratification of patients based on metabolic ...
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Spermine Protects Mice Against Lethal Sepsis Partly by Attenuating Surrogate Inflammatory Markers
... Interestingly, most of the cytokines/ chemokines that were inhibited by sper- mine both in vivo and in vitro, have been considered as surrogate markers of lethal experimental sepsis (39,40). For instance, ...
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