SW1990 cells
Huachansu injection inhibits metastasis of pancreatic cancer in mice model of human tumor xenograft
... of SW1990 cells as well as the cell viability of three cell lines (SW1990, BxPC3 and CF-PAC1), and in vivo the number of liver metastases was decreased, accompanied with the ratio of liver-body ...
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Original Article SphK1 is involved in the progression of human pancreatic cancer
... Abstract: Sphingosine kinase 1 (SphK1) expression is elevated in various cancers and is associated with shorter survival times for patients. However, the effect of SphK1 in pancreatic cancer (PC) remains unclear. In this ...
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Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro
... melanoma cells by regulating the gene transcription of ...in SW1990 cells, and IL-6 significantly increased MMP-2 mRNA and protein expression in Capan-2 cells through activation of the Stat3 ...
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<p>Honokiol Suppressed Pancreatic Cancer Progression via miR-101/Mcl-1 Axis</p>
... and SW1990 cells were seeded in a 96-well plate at a density of 1500 ...and cells were washed with phosphate buffered saline (PBS). Then, the cells were incubated with MTT (5 mg/mL) for 3 h at ...
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Luteolin decreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6 induced epithelial–mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cells
... Notes: Two cell lines were treated with luteolin at concentrations of 0, 20, 40, 80, and 160 μM for 24 hours. (A) Fold change in cell viability of sW1990 and Panc-1 cells. (B) Single and merged images show ...
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LncRNA DLX6-AS1 promoted cancer cell proliferation and invasion by attenuating the endogenous function of miR-181b in pancreatic cancer
... DLX6‑AS1 knock‑down inhibited tumor growth in vivo SW1990 cells stably transfected with shDLX6-AS1 or shNC were injected into the nude mice. As shown in Fig. 6a, DLX6-AS1 knockdown inhibited tumor growth ...
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Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism
... in SW1990 cells ...of SW1990 cells treated with increasing doses of AO for 48 ...of SW1990 cells in the S phase ...untreated cells) and a decrease in the percentage of ...
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Bioinformatics analysis combined with experiments to explore potential prognostic factors for pancreatic cancer
... were selected for further study because the expression levels of DLGAP5 in SW1990 and Capan-2 cells were highest. The knockdown efficiency was evaluated by siRNA knockdown of DLGAP5, RT-qPCR, and Western ...
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Development of a novel method to evaluate sialylation of glycoproteins and analysis of gp96 sialylation in Hela, SW1990 and A549 cell lines
... carcinoma, SW1990 pancreatic adenocarcinoma, and A549 lung adenocarcinoma ...in SW1990 cells was 30–40 % lower than that in A549 and HeLa cells, and the amount of sialylated gp96 in ...
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Metabolic flux-driven sialylation alters internalization, recycling, and drug sensitivity of the epidermal growth factor receptor (EGFR) in SW1990 pancreatic cancer cells
... of SW1990 cells had a similar ...untreated cells, we concluded that the previously-reported dimerization mechanism offered, at most, only a partial explanation for the impact of 1,3,4-O-Bu 3 ManNAc ...
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mir-329 restricts tumor growth by targeting grb2 in pancreatic cancer
... pancreatic cancer cell lines by transfecting miR-329 mimics or miR-329 scramble (miR-NC) into BxPC3 and SW1990. The upregulated level of miR-329 was confirmed by qPCR after transfection (Figure 2A). Then we ...
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Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma
... control cells receiving DNA damage, a little cleaved PARP-1 would be detected because of the cell cycle arrest and thus, the cells had enough time to repair the double-strand ...and SW1990 ...
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FOLFOX regimen plus dendritic cells–cytokine-induced killer cells immunotherapy for the treatment of colorectal cancer: a meta-analysis
... Purpose: To systematically investigate the efficacy and safety of the combination of FOLFOX (oxaliplatin, 5-fluorouracil, and leucovorin) regimen and cocultured dendritic cells and cytokine- induced killer ...
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Mast cells positive to tryptase, endothelial cells positive to protease-activated receptor-2, and microvascular density correlate among themselves in hepatocellular carcinoma patients who have undergone surgery
... mast cells positive to the antitryptase ...mast cells. Big arrows indicate single mast cells adjacent to a microvessel and double small arrows indicate red immunostained tryptase forming a ...
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<p>Targeting Pancreatic Cancer Cells and Stellate Cells Using Designer Nanotherapeutics in vitro</p>
... treated cells illustrating the internaliza- tion of nanoparticles (Figure ...trypsinized cells captured after treatment with targeted nanoconjugates also con fi rmed enhanced cellular uptake of targeted ...
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<p>DEP Domain-Containing Protein 1B (DEPDC1B) Promotes Migration and Invasion in Pancreatic Cancer Through the Rac1/PAK1-LIMK1-Cofilin1 Signaling Pathway</p>
... in PC cells. Furthermore, our data showed that EHop-016, an inhibitor of Rac1 and potentially an anti-metastatic cancer drug, 32 could effectively suppress the Rac1/PAK1-LIMK1- co fi lin1 pathway activation induced ...
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Original Article Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
... of cells was harvested 24 hours after radiation treatment, and the cells were placed in Eppendorf tubes for centrifugation at 12,000 rpm for 1 ...of Sw1990 pancreatic cancer ...
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Embryonic stem cells differentiate into insulin producing cells without selection of nestin expressing cells
... Cells were suspended in lysis buffer (4 M guanidinium thiocyanate, 25 mM sodium citrate, pH 7; 0.5% sarcosyl, 0.1 M β -mercaptoethanol). Total RNA was isolated by the single step extraction method according to ...
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Elimination of mouse tumor cells from neonate spermatogonial cells utilizing cisplatin-entrapped folic acid-conjugated poly(lactic-co-glycolic acid) nanoparticles in vitro
... green cells indicate the TUNel-positive apoptotic ...apoptotic cells increased after 48 hours in the group treated with 2 mg/ ml cDDP/Plga NPs: (A) TUNel assay; (B) DaPI staining; and (C) ...el4 ...
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Dendritic cells fused with different pancreatic carcinoma cells induce different T-cell responses
... after the second stimulation by DCs fused with QGP-1, as a cell line that induced a low level of cytotoxicity, or DCs fused with KP-3L, as a cell line that induced a high level of cytotoxicity. As a control, cytokines in ...
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