Synovial fibroblast
Citrullination of fibronectin modulates synovial fibroblast behavior
... We assessed whether citrullinated fibronectin would alter matrix degradation, a pathologic function of syno- vial fibroblasts in rheumatoid arthritis. We found no dif- ference in the number of degrading cells in the ...
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Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis
... reduced synovial fibro- blast migration, but that FAK protein itself did not appear to be ...reduce synovial fibroblast migration in transwell experi- ...in synovial fibroblast ...
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The effect of bacterial products on synovial fibroblast function: hypermetabolic changes induced by endotoxin
... The effects of bacterial products on selected synovial fibroblast functions were studied. Extracts of commonly encountered microorganisms were prepared by sonic or mechanical disruption. “Purified” ...
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Fibroblast biology Effector signals released by the synovial fibroblast in arthritis
... The synovial fibroblast has emerged as a pivotal effector cell in the inflamed joint, based on its ability to degrade the extracellular matrix and to provide chemotactic and activa- tion signals to resident ...
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Functional analysis of an arthritogenic synovial fibroblast
... lung fibroblast; MHC = major histocompatibility complex; MMP = matrix metalloproteinase; PBS = phosphate-buffered saline; PCR = polymerase chain reaction; RA = rheumatoid arthritis; RT = reverse transcriptase; ...
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Influences of gamma interferon on synovial fibroblast like cells Ia induction and inhibition of collagen synthesis
... adherent synovial fibroblastlike cells continued to be Ia-positive when examined as long as 10 d after the removal of gamma ...fibroblasts. Synovial cells that could be induced to express Ia also bound a ...
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In vitromodel for the analysis of synovial fibroblast mediated degradation of intact cartilage
... In an attempt to replace, or at least reduce, the number of ani- mal experiments, several co-culture models of cartilage destruction have been established to date. Besides differ- ences in the co-cultured cell types and ...
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The Vitamin D Receptor Regulates Rheumatoid Arthritis Synovial Fibroblast Invasion and Morphology
... some proliferator-activated receptor gamma (Pparγ) and retinoic acid receptor gamma (Rxrγ), as well as NR target genes in syn- ovial tissues of protected rats, suggesting a new antiinflammatory and homeostatic role for ...
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A cell cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis
... of synovial fluids collected from patients with RA (or control agents) were added to the top wells and the chambers were incubated overnight at ...basic fibroblast growth fac- tor (bFGF; R&D Systems, ...
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Fibroblast biology Signals targeting the synovial fibroblast in arthritis
... guides fibroblast migration as an immobilized substrate and attractant in the leading edge of the pannus (haptotaxis) ...of synovial lining and lymphocyte migration ...the synovial membrane [45]. ...
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Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis
... on synovial tissue and uncoupling of bone metabolism through a paracrine ...by synovial fibro- blasts that extends beyond DKK1 with an increase in several antagonists and a suppression of ...
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Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys?
... the synovial cavity ...normal synovial joints of mice carrying green-fluorescent protein (GFP)- positive bone marrow comprised approximately 1% of GFP-positive (bone marrow-derived) fibroblast-like ...
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The proinflammatory cytokines IL 1β and TNF α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2 ETS1 pathway
... As an E3 ubiquitin ligase on the ER membrane, SYN functions as an ER-associated degradation system in both yeast and mammals [8,9]. The biological functions of SYN were analyzed in SYN transgenic mice and heterozygous ...
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Transcriptional profiles discriminate bone marrow derived and synovium derived mesenchymal stem cells
... the synovial membrane by the same protocol as that used for synovial fibroblast cultivation, suggesting that MSC correspond to a subset of the adherent cell population, as MSC from the stromal ...
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NF κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony stimulating factor
... RA fibroblast-like synovial cells (FLS) were prepared from the synovial tissues as described previously [22], and were cul- tured in DMEM with heat-inactivated 10% FCS (Sigma- ...
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Fibroblast-like synovial cell production of extra domain A fibronectin associates with inflammation in osteoarthritis
... OA synovial tissue, induction of ED-A fibronectin production by TGFβ, and co-localization of ED-A fibronectin and αSMA in the OA ...OA synovial fluid ...
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Current perspectives on synovitis
... of synovial tissue may also play an important role in the development of rational therapies in which biotech- nology products are used to influence defined patho- genetic mechanisms ...
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The inhibitory activity of human interleukin 1 receptor antagonist is enhanced by type II interleukin 1 soluble receptor and hindered by type I interleukin 1 soluble receptor
... monocytes/macrophages. At the inflammatory site, IL-1 is a potent inducer of the production of prostaglandin E2 (PGE2) and metalloproteinases on fibroblast-like cells, thus triggering tissue damage. The biological ...
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Chemerin activates fibroblast like synoviocytes in patients with rheumatoid arthritis
... FLS: fibroblast-like synoviocyte; IFN: interferon; IL: interleukin; JNK: c-Jun N- terminal kinase; mAb: monoclonal antibody; MAPK: mitogen-activated protein kinase; MEK: mitogen-activated protein kinase kinase; ...
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Fucosyltransferase 1 mediates angiogenesis, cell adhesion and rheumatoid arthritis synovial tissue fibroblast proliferation
... RA synovial fibroblasts, qPCR was ...RA synovial fibroblasts was significantly higher than in nonstimulated NL synovial fibroblasts ...RA synovial fibroblasts was also significantly elevated ...
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