Synthesis and Biological Evaluation
Synthesis and biological evaluation of indoles
... their biological activities evaluated in recent ...the synthesis of various 2-(2-amino ethyl)- indoles and 2-(2-aminopropyl) indoles prepared for biological ...the synthesis of the title ...
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Chemical synthesis, hydrolytic stability, and biological evaluation of 4’ thionucleosides and their analogs
... mentioned biological applications of the 4’- thionucleosides, it appears important to also compare their intrinsic chemical properties to those of their native counter- ...their synthesis and ...
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Molecular Design, Synthesis, Characterization and Biological Evaluation of 1-Substituted Tetrahydropyrimidine Derivatives by Leuckart Reaction.
... DESIGN, SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 1-SUBSTITUED TETRAHYDROPYRIMIDINE DERIVATIVES BY LEUCKART REACTION” was done by ...
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Design Synthesis, Characterization and Invitro Biological Evaluation of Novel Series of 1- Substituted Isatin Derivatives by Mannich Reaction.
... DESIGN SYNTHESIS, CHARACTERIZATION AND INVITRO BIOLOGICAL EVALUATION OF NOVEL SERIES OF 1- SUBSTITUTED ISATIN DERIVATIVES BY MANNICH REACTION was done by Mr ...
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Design Synthesis Characterization and Biological Evaluation of Some Novel Benzothiazole Derivatives as Anti Tubercular Agents Targeting Glutamine Synthetase 1
... “DESIGN, SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL BENZOTHIAZOLE DERIVATIVES AS ANTI-TUBERCULAR AGENTS TARGETING GLUTAMINE SYNTHETASE 1” submitted by the candidate bearing ...
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The Design, Synthesis, and Biological Evaluation of Steroid-Derived Inhibitors of the Sonic Hedgehog Signaling Pathway
... high-throughput biological evaluation, we are continuing to design and synthesize novel antagonists of the SHH pathway in hopes to further understand the binding pocket of ...
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Synthesis and Biological Evaluation of Some Novel 3,4-Disubstituted Isocoumarins
... There are several examples reported in literature where the presence of nitrogen atom in compounds, in various forms, has shown tremendous therapeutic applications. In continuation of our efforts to adapt ...
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Synthesis and biological evaluation of chalcones having heterosubstituent(s)
... In this sequence a series of chalcones were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines.. In addition the synthetics reduced M[r] ...
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DESIGNING, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL PYRIDAZINONE DERIVATIVES
... and synthesis of selected 6-(4-methylphenyl)-4,5-dihydropyridazin-3(2H)-one, 6-(4- benzylphenyl)-4,5-dihydropyridazin-3(2H)-one and 6-(4-phenoxyphenyl)-4,5-dihydropyridazin-3(2H)-one derivatives was carried out ...
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TOWARDS THE TOTAL SYNTHESIS OF PHORBOXAZOLE A, SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN ANALOGUES AS DNA GYRASE INHIBITORS AND DEVELOPMENT OF NEW SYNTHETIC METHODOLOGIES
... The present studies demonstrate the synthesis of these hybrid molecules and evaluate their antibacterial activity as well as their ability to inhibit DNA gyrase. These new coumarin based hybrids exhibit moderate ...
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Synthesis and biological evaluation of ? -aroylpropionic acid based 1,3,4-oxadiazoles
... A fair number of compounds were found to have good antiinflammatory activity in carrageenan-induced rat paw edema test, while a few compounds showed significant antibacterial activity.[r] ...
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Synthesis and biological evaluation of triazine derivatives
... 1, 2, 4-triazine heterocyclic entity are very interesting components in terms of their biological properties, such as antifungal, antibacterial and herbicidal. Synthesized compounds 4a-4l were tested against a ...
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
... Regiospecific Synthesis of 1,4,5-Trisubstituted-1,2,3-triazole via One-Pot Reaction Promoted by Copper(I) ...Salt. Synthesis 2005, 8, ...Catalyzed Synthesis of ...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF 1,3-THIAZINES- A REVIEW
... The multifaceted chemical potential of 1, 3-thiazine- a six membered motif/species containing nitrogen and sulphur in the ring has led to unabated research in their synthetic methodologies. This paper summarizes various ...
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The Design, Synthesis, and Biological Evaluation of Dimeric Β-Carbolines Based on the Structure of Neokauluamine and the Study of Manzamine A Dimerization Toward Neokauluamine
... interesting biological activities of dimeric β-carboline (25) against various NSCLC cell lines led us to further study its cellular mechanism to induce cell death in H1299 ...
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Design, synthesis, and biological evaluation of novel <strong>EF24 </strong>and <strong>EF31 </strong>analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer
... Moreover, biological assays of anti-PC efficacy of D6 indicated effective inhibition of proliferation, as well as the activation of IKK β /NF- κ B pathway, and induction of apoptosis of PC ...
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Synthesis and biological evaluation of delavayin-C
... total synthesis of cyclic peptide, cyclo(gly-tyr-tyr-tyr-pro-val-pro), it was disconnected into three dipeptide units, Boc-gly- tyr-OMe 1, Boc-tyr-tyr-OMe 2, Boc-pro-val-OMe 3 and a single amino acid methyl ester ...
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Synthesis and Biological Evaluation of N-heterocycles for Activity on Monoamine Transporters and Exploration of Iridium Chemistry for Synthesis of Medicinally Important Molecules
... for synthesis of Altinicline (SIB-1508Y), a preclinical drug candidate for Parkinson’s ...the synthesis of nicotine-related ...the synthesis of nicotine related compounds, and the first total ...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF 1-SUBSTITUTED IMIDAZOLE DERIVATIVES
... General procedure for the synthesis of compounds (P1-P14) 9 : To a well-stirred solution of 4-(1H- imidazol-1-yl)benzoyl chloride (0.01mol) and triethylamine (0.01mol) in benzene, substituted anilines (P1-P10) and ...
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Insilico design, synthesis, characterization and biological evaluation of some novel 1 hydroxynapthelene 2 yl derivatives
... few Synthesis of 1-(1-hydroxynaphthalen ethanone from α-napthol and to synthesize 1 hydroxynapthalen-2-yl derivatives by reacting 1 hydroxynapthalen-2-yl) ethanone with substituted benzaldehydes ...
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