Synthetic analogues
The role of carboxylic group position on the antiradical activity of synthetic analogues of oat antioxidants
... Immediate reaction with free radicals is highly desirable property of antioxidant. The reaction of cinnamoyl anilines with DPPH achieved the plateau within few minutes, but the reaction of corresponding piperidinium ...
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Exploiting Cancer Cell Mitochondria as a Therapeutic Strategy: Structure Activity Relationship Analysis of Synthetic Analogues of Pancratistatin
... the synthetic derivatives of pancratistatin for this ...(CA4) analogues for the synthetic CA4 ...providing synthetic analogues of curcumin for the synthetic curcumin ...
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Novel synthetic analogues of Fluoxetine as potent and selective anti-TB agents
... Our group has recently reported anti-TB activity for fluoxetine. This drug is a very important ingredient in antidepressant formulations currently used around the world. Hence, it cannot be considered for drug ...
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Anti-Cancer Properties of Synthetic Analogues of the Natural Compounds Colchicine and Curcumin
... to! natural! curcumin.! We! showed! that,! like! curcumin,! our! compounds! induced! apoptotic! morphology! in! SUM! 149! nuclei! and! cells.! We! saw! that! the! nuclei! of! the! treated! cells! were! brightly! stained! ...
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Synthesis and antioxidant activities of naturally occurring alpinum isoflavone, 4′ O methylalpinum isoflavone and their synthetic analogues
... Naturally occurring isoflavone viz, alpinum isoflavone, 4 ′ -O-methylalpinum isoflavone, and a series of five analogues were synthesized by prenylation of isoflavone (4) which was synthesized from phloroglucinol. ...
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Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis
... 14 In summary, parasitic worm products are increasingly being considered as novel therapeutics for human illnesses associated with aberrant inflammatory responses (reviewed by Rzepecka and Harnett, 2014). We have ...
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Characterization of the LM5 pectic galactan epitope with synthetic analogues of β-1,4-d-galactotetraose
... β-1,4-tetragalactoside analogues 1-3 (Figure 1). In the three synthetic oligosaccharides, the axial C4-OH in the non-reducing end residue was replaced with C4-F, C4-OMe and the C4-epimer, ...
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<p>Molecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib</p>
... The surface expression of P-selectin was studied in a FACSCalibur fl ow cytometer (Becton-Dickinson, San Jose, CA, USA) using the fl uorescently labeled monoclo- nal antibody (anti-CD62P-PE) as we previously described with ...
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Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis
... Results: The most bioactive sub-fractions derived from CG comprised of ethyl gallate, gallic acid and polyphenols. Five alkyl/alkenyl gallates were synthesized. A preliminary structure-activity relationship of gallic ...
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The Effects of Hydrogen Bonding on the Reactivity of Synthetic Ada Repair Protein Analogues
... metalloprotein, synthetic analogues are complexes that mimic the primary (and sometimes secondary) coordination sphere present in the active site of the ...as synthetic analogues being easier ...
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A Combination of Short and Simple Surfactant Protein B and C Analogues as a New Synthetic Surfactant: In Vitro and Animal Experiments
... in 2015, which showed stable reproducibility. SP-CL16 has poly-Leucine residues, unlike human SP-C, which has poly-Valine residues. This prop- erty confers more stable amphipathic features. Furthermore, there is another ...
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Synthetic BicycIic Analogues of Quassinoids
... amoebicidal and antifeedant.' Two examples of the quassinoids are bruceantin 1 and dehydrobruceantin 2.~The features considered important for biological activity in the quassinoids inclu[r] ...
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SYNTHETIC STUDIES TOWARDS THE COMMON POLYKETIDE FRAGMENT OF HOIAMIDES, AZUMAMIDE-E ANALOGUES, 1,2,3-TRIAZOLES AND PEPTIDOFOLDAMERS
... 3. Parallel to its effect on cell cycle arrest, compounds 1, 2 and 3 were found to inhibit cellular histone deacetylase activity derived from cell lysate directly. The histone deacetylase activity was almost completely ...
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Molecular Docking and Synthesis of 1, 2, 4 - Triazin Analogue of Diclofenac as Potential Ligand for Chlorpromazine Induced Parkinson’s in Rat Model
... 7.1 Synthetic scheme of designed compounds 51 7.2 Ft-ir analysis of diclofenac analogues 52 7.3 Molecular docking studies of 1, 2, 4-triazin derivative of 56 diclofenac on molecular dock[r] ...
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Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues
... It is known that natural products tend to target multiple mechanisms leading to tumor inhibition. Oridonin is a naturally occurring 7,20-epoxy-ent-kaurane diterpenoid isolated from Isodon rubescens traditionally used in ...
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Synthetic Characterization & Antimicrobial Screening of Some Novel 6-Fluorobenzothiazole Substituted [1, 2, 4] Triazole Analogues
... The fungal activity of the compounds was determined by means of the disc-diffusion method.. The inhibition zones were measured with a caliper considering the total diameters.[r] ...
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Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62
... and here we demonstrate that four synthetic ES-62 SMAs - 11a, 11e, 11i and 12b, are similarly capable of targeting these cells. Studies in vitro revealed that like ES-62, the SMAs render bmDCs refractory to full ...
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TOWARDS THE TOTAL SYNTHESIS OF PHORBOXAZOLE A, SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN ANALOGUES AS DNA GYRASE INHIBITORS AND DEVELOPMENT OF NEW SYNTHETIC METHODOLOGIES
... scarce natural products arrest cancer cell growth in S phase at low to subnanomolar concentrations, making them promising candidates for therapeutic development. The enormous biological activity and the fascinating ...
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Absorption, Plasma Transport, and Cellular Retention of Cobalamin Analogues in the Rabbit: EVIDENCE FOR THE EXISTENCE OF MULTIPLE MECHANISMS THAT PREVENT THE ABSORPTION AND TISSUE DISSEMINATION OF NATURALLY OCCURRING COBALAMIN ANALOGUES
... Cbl analogues were bound with low affinity by intrinsic factor, and none of these [ 57 Co]Cbl analogues were taken up by the ileum or absorbed into the body in amounts comparable to that of [ 58 ...Cbl ...
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Adefovir dipivoxil is less expensive than lamivudine and associated with similar prognosis in patients with hepatitis B virus-related hepatocellular carcinoma after radical resection
... Results: Despite significant improvement in HBV-DNA and alanine aminotransferase level in the LAM group after 1 year of antiviral therapy, these parameters did not differ significantly between the two groups over the ...
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