SYNTHETIC-LETHAL
Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer
... Synthetic lethal interactions of FBXW7 and its validation Having identified FBXW7 as a candidate gene worth exploring further, its yeast ortholog and expression in other cancers was ...
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Predicting synthetic lethal genetic interactions in Saccharomyces cerevisiae using short polypeptide clusters
... Protein synthetic lethal genetic interactions are useful to define functional relationships between proteins and ...of synthetic lethal genetic interactions remains ...yeast synthetic ...
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ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.
... ARID1A/ATRi synthetic lethal interaction using a number of orthogonal ...the synthetic lethality was not specific to VE-821 (Supplementary Figure ...
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Synthetic Lethal Interactions Suggest a Role for the Saccharomyces cerevisiae Rtf1 Protein in Transcription Elongation
... our synthetic lethal screen, we also examined if rtf1⌬ chd1 double mutant strains exhibit any genetic interac- ...no synthetic phenotypes for these strains (data not ...
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Ranking novel cancer driving synthetic lethal gene pairs using TCGA data
... potential synthetic lethality pairs for further experimental validation represent an attractive ...of synthetic lethal gene pairs for cancer ...
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Identification of potential synthetic lethal genes to p53 using a computational biology approach
... candidate synthetic lethal genes to p53 using gene expression ...druggable synthetic lethal genes to ...p53 synthetic lethal ...putative synthetic lethality relationships ...
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The pkaB Gene Encoding the Secondary Protein Kinase A Catalytic Subunit Has a Synthetic Lethal Interaction with pkaA and Plays Overlapping and Opposite Roles in Aspergillus nidulans
... is lethal, indicating that PkaB and PkaA are essential for viability of ...a synthetic lethal interaction with PkaA, and it plays an overlapping role in vegetative growth and spore germination in the ...
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PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency
... survival. PARG depletion had no impact on the viable cell number at 72 h after siRNA transfection of MDA- MB-468 cells, and did not affect the clonogenic survival of MDA-MB-468 cells, inferring that PARG-deficiency is ...
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Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer
... The role of BRG1 in cancer appears to be dependent on tumor type and subunit (25, 31). Frequent mutation and/or loss of expres- sion of the catalytic subunit of BRG1 has been reported (26, 27). Nevertheless, an ...
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Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)
... Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline ...
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CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours.
... KRAS synthetic lethal interactions, we first generated and validated an isogenic cell line system to model the presence or absence of oncogenic KRAS ...
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Synthetic lethal interaction of cetuximab with MEK1/2 inhibition in NRAS -mutant metastatic colorectal cancer
... Cetuximab synergistically triggers apoptotic cell death with MEK1/2 inhibitors in NRAS mutant mCRC cells To mechanistically explore the apparent synthetic lethal interaction between cetu[r] ...
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Hocke, Sandra (2016): A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers. Dissertation, LMU München: Medizinische Fakultät
... of synthetic lethal interactions of ATR with ...synthetically lethal effects only in one cell line (U2OS bone osteosarcoma cells) (130), our study provides data on the specific killing of cells ...
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Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma
... called synthetic lethal (a type of genetic interaction described in [4]) when a simultaneous mutation of both genes leads to cell death, but a single mutation of either does ...throughput synthetic ...
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Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer
... be synthetic lethal with six key DNA-damage response (DDR) genes in these ...(synthetic) lethal upon knockdown in these cell ...identifies synthetic lethal combinations in ...
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Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors
... ago, synthetic lethal approaches induced by Poly-(ADP-ribose)-polymerase (PARP) inhibitors (PARPi) have given renewed enthusiasm to developing anticancer treatments that can specifically target cancer cells ...
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Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
... of synthetic lethal genes which are involved in RAS processing ...same synthetic lethal effects were reconfirmed in isogenic matched Ba/F3 cells with a NRAS ...RAS synthetic ...
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Predicting synthetic lethal interactions using conserved patterns in protein interaction networks.
... PARP inhibitors are the most developed therapies that exploit SSL interactions. The PARP inhibitor Olaparib, has been approved for the treatment of patients with recurrent, platinum- sensitive, high-grade serous ovarian ...
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Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib.
... Ovarian cancer is the most lethal gynaecological malignancy. The OCCC subtype presents a particular clinical management challenge as it is invariably characterised by resistance to standard chemotherapy as well as ...
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High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma
... The identification of HHT in our screen demonstrates that we can successfully find drugs that act as synthetic lethal agents when combined with VHL mutation using this strategy. HHT is a natural plant ...
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