T brucei
Pharmacological Investigation of Solanum Incanum Against P. Falciparum, L. infantum, T. cruzi and T. brucei : A Role of Antioxidant Effect and Clinical overview
... Solanum incanum antiprotozoal effect has been reported for the first time against P. falciparum, L. infantum, T. brucei and T. cruzi. S. incanum fruits had stronger antioxidant profile. Among tested ...
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A differential role for actin in the life cycle of T brucei
... lectin, from the Golgi to the endosomal/lysosomal compart- ments (Brickman and Balber, 1993, 1994; Nolan et al, 1997, 1999). Presumably, loss of traffic from the pocket leads to an accumulation of these proteins in the ...
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Analysis of risk factors for T brucei rhodesiensesleeping sickness within villages in south east Uganda
... The infection occurs in two distinct forms: East-African (T. b. rhodesiense) and West-African trypanosomiasis (T. b. gambiense). Although human-infective parasites have also found in animals in West Africa ...
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Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
... Inducible RNAi knockdown of TbCet1. TbCet1 was depleted in T. brucei by using a tetracycline-inducible RNAi system as described previously (45). A 352-bp DNA fragment of the TbCET1 open reading frame (from ...
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Cryptic Paraflagellar Rod in Endosymbiont-Containing Kinetoplastid Protozoa
... or T. brucei genomic DNA templates (prepared as described in reference ...and T. brucei templates generated amplicons encoding fragments of both PFR1 and PFR2 proteins, whereas those from ...
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INVESTIGATION OF LIVESTOCK FOR PRESENCE OF TRYPANOSOMA BRUCEI GAMBIENSE IN TAFA LOCAL GOVERNMENT AREA OF NIGER STATE, NIGERIA
... Blood samples from a total of 460 animals made up of 177 white Fulani/Zebu cattle, 209 Yankasa sheep, 61 red Sokoto goats, 12 local dogs and 1 monkey were examined individually for the presence of pathogenic trypanosomes ...
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TbDSS-1, an Essential Trypanosoma brucei Exoribonuclease Homolog That Has Pleiotropic Effects on Mitochondrial RNA Metabolism
... Trypanosoma brucei, posttranscriptional mechanisms of gene regulation are of major ...in T. brucei also require an extensive RNA editing process involving uridine insertion and deletion to form ...
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Whole Genome sequencing of Trypanosoma brucei reveals introgression between subspecies that is associated with virulence
... of T. brucei are present in the ...tween T. b. brucei and ...African T. b. brucei is more similar to ...between T. b. rhodesiense and West African T. b. ...
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Trypanosoma brucei RRM1 Is a Nuclear RNA Binding Protein and Modulator of Chromatin Structure
... SR proteins in higher eukaryotes have multiple functions in tran- scription, RNA processing, RNA export, and control of stability (58). Importantly, they can link transcription to chromatin struc- ture by binding nascent ...
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Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling
... of T. brucei and in the culture medium are Na + and K + ...of T. brucei are low- Na + and high-K + cells [22], only a salinomycin-mediated transport of Na + from the exterior to the interior ...
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Mitochondrial DNA Ligases of Trypanosoma brucei
... the T. brucei sequence. The T. brucei ligase sequences have also been compared to other ligase sequences (Table ...the T. brucei mitochondrial LIG k␣ and LIG k  sequences to ...
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Multiple Triclosan Targets in Trypanosoma brucei
... Triclosan did not ameliorate T. brucei infections in mice. We tested the efficacy of triclosan in an in vivo mouse model of T. brucei infection. Although we used up to 50 mg of triclosan/kg of ...
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Cerebral vessel laminins and IFN γ define Trypanosoma brucei brucei penetration of the blood brain barrier
... Trypanosoma brucei. T. brucei para- sites are transmitted by the tsetse fly, and after the initial skin infection, the parasites spread via the lymph and blood circula- tion within the ...which ...
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Rab23 is a flagellar protein in Trypanosoma brucei
... Genomes were chosen for sampling based on three main criteria: i) proposed position in the evolutionary tree of eukaryotes [21] ensuring adequate representation of major supergroups, ii) completeness of the sequenced ...
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Domestic pigs as potential reservoirs of human and animal trypanosomiasis in Northern Tanzania
... In Tanzania AAT has a large impact on animal health, second only to tick-borne East Coast Fever [59]. Cattle make up the majority of livestock kept in Tanzania and the main pathogenic species to affect cattle are ...
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Genome-Wide Analysis of C/D and H/ACA-Like Small Nucleolar RNAs in Leishmania major Indicates Conservation among Trypanosomatids in the Repertoire and in Their rRNA Targets
... of T. brucei C/D and H/ACA RNAs ...in T. brucei (14 C/Ds and 10 H/ACAs) in these ...the T. brucei homologue ...in T. brucei, are present in two separate ...in ...
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Regulation of the Cell Division Cycle in Trypanosoma brucei
... Cytokinesis is the final step of cell division and requires a complex interplay of many regulatory proteins at the cytokinesis initiation site and on the cleavage furrow. It also requires the interplay be- tween the ...
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The roles of cytoplasmic aspartate aminotransferase in trypanosoma brucei
... in T. brucei, where the final step in methionine regeneration would be the TbcASAT catalysed transamination of KMTB with an amino group abstracted from other amino acids ...
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Haematological indices in Trypanosoma brucei brucei (Federe isolate) infected Nigerian donkeys (Equus asinus) treated with homidium and isometamidium chloride of ciprofloxacin in broiler chickens after single intravenous and intraingluvial administration
... with T. b. brucei (Federe isolate) was ...with T. brucei brucei (Federe isolate) developed symptoms of trypanosomosis; anaemia, lymphocytosis and ...of T. brucei ...
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The Trypanosomal Transferrin Receptor of Trypanosoma Brucei—A Review
... the T. brucei ES’s, the BSF trypanosome also has a more limited repertoire of ESAGs (Figure 3) ...the T. brucei clade, sequencing has revealed about 12 polymorphic genes comprising the ESAGs, ...
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