T-cell Activation and Proliferation
Helios Expression Is a Marker of T Cell Activation and Proliferation
... Foxp3+ T-regulatory cells (Tregs) normally serve to attenuate immune responses and are key to maintenance of immune ...CD4+ T cells. We investigated Helios expression in murine and human T cells ...
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T cell activation without proliferation in juvenile idiopathic arthritis
... and activation phenotype of T cells in synovial fluid (SF) from patients with juvenile idiopathic arthritis (JIA) is associated with T-cell proliferation in ...and activation ...
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Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism
... suppress T cell pro- liferation in vitro via rapid and selective degradation of tryptophan by ...the T cell–derived signals IFN- g and CD40- ...Purified T cells activated under ...
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HIV Immunopathogenesis: Inhibition of CD4+ T Cell Activation
... CD4+ T cell ...human T regulatory cells (Treg) using an in vitro model ...CD4+ T cell proliferation is independent of ...CD4+ T cell immunity were then moved to an ...
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Spatial Dynamics and the Mechanoresponse in CD4+ T Cell Activation
... where the immune system fails in one of these two primary tasks. A failure in targeting a valid antigen leads to proliferation of undesired cells, whereas an unintended response against native tissue leads to ...
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Control of immunoregulatory molecules by miRNAs in T cell activation
... the T lymphocyte promoting cell survival, proliferation and production of effector molecules, such as ...either T cell activation (booster) or inhibition ...
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CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation
... MUC1-targeted T cells retained effector function in the suppressive tumor microenvironment, we paired our CAR with a chimeric receptor designed to harness and invert the inhibitory effects of tumor-produced ...
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T cell activation promotes tumorigenesis in inflammation associated cancer
... promotes proliferation of Tax expressing LGL cells that have been recruited to the wound ...the activation of T- cells that have also been recruited to the ...Activated T-cells release ...
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Coordinate Regulation of T Cell Activation by CD2 and CD28 1
... to T cells lacking only CD2 or CD28, we found that T cells deficient in both proteins were severely im- paired in their ability to be activated and proliferate in response to stimulation by either soluble ...
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Fc γ receptors and the complement system in T cell activation
... + T cells directly in vivo, wild-type and CD11c-DTR transgenic mice were injected with CFSE-labelled OVA-specific CD4 + T cells and immunized with ...induces T-cell prolifer- ation in both ...
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A global transcriptional view of apoptosis in human T-cell activation
... of T-cell activation by mediating the induction of various genes that control T-cell proliferation, activa- tion and survival ...in T-cell activation is far ...
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Original Article CD4 T cell proliferation and inhibition of activation-induced cell death (AICD) in childhood asthma
... + T cells from children in the asthma group was significantly decreased com- pared to that from the children in the normal control group, whereas the Bcl-2 expression was significantly higher than that from ...
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Effects of in vitro corticosteroids on B cell activation, proliferation, and differentiation
... B cell activation, proliferation, and ...as activation and proliferation of high-dose anti-mu or Staphylococcus aureus-stimulated B cells are profoundly suppressed by the presence of in ...
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Reciprocal control of T cell- and APC-activation
... 3A9 T cells, since there is no nom inal antigen present at the first data point (0 nM High starting levels of IL-2 could also be responsible for the slightly but significantly higher levels of background ...
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SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis
... inhibited cell proliferation under hypoxic conditions, possibly due to ineffective deSUMOylation and stablization of Hif-1α related to the SENP-1 ...
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Transcriptional activation of CBFβ by CDK11p110 is necessary to promote osteosarcoma cell proliferation
... Conclusions In conclusion, we have taken a genetic approach to under- standing CDK11 regulated genes in osteosarcoma. A sys- tematic combination of global gene expression profiling and DNA-protein assays has led to a ...
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Transcriptional activation of CBFβ by CDK11p110 is necessary to promote osteosarcoma cell proliferation.
... Immunohistochemical staining on TMA The expression levels of CBFβ and CDK11 were deter- mined based on the immunohistochemistry protocol (Paraffin) from Cell Signaling Technology (Beverly, MA) as previously ...
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LKB1 is essential for the proliferation of T cell progenitors and mature peripheral T cells
... LKB1 fl/fl thymi although there was a population of CD44 ! CD25 low cells that resembled cells in transition from the DN3 to DN4 stage. Numbers of DN4 thymocytes were 1.6–3.7 " 10 6 in LckCre 1 LKB1 1/1 thymi while the ...
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Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation.
... controlling cell growth, survival, fate and pattern of the body ...fibroblast activation in vitro ...with cell proliferation and the expression of myofibroblastic markers in ...
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Frequency, Proliferation, and Activation of Human Memory T Cells Induced by a Nonhuman Adenovirus
... frequencies, proliferation, activa- tion, and phenotypic characteristics of human T cells stimu- lated by CAV-2 virions and capsid proteins versus ...of T-cell proliferative responses and ...
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