T cell depletion
Apoptosis and T-cell depletion during feline infectious peritonitis.
... of T cells (14, 15, ...in T cells can nevertheless induce T-cell depletion. T-cell suppression may enhance viral replication during ...that cell-mediated immunity ...
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HIV 1 infection and CD4 T cell depletion in the humanized Rag2 / γc / (RAG hu) mouse model
... human cell engraftment in peripheral blood and to detect various human hemat- opoietic cell populations in different lymphoid ...single cell preparations were made followed by RBC lysis. Cell ...
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Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion
... CD4 T cell immunity in reactiva- tion, monkeys were treated with a single 50-mg/kg dose of a humanized monoclo- nal anti-CD4 antibody; within 1 week, circulating CD4 T cells were reduced from 40 to ...
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Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV 1 and SIV infections
... The link established here among fibrosis, damage to the LT niche through loss of access and a source of IL-7 on the FRC network, and naive T cell depletion clearly argues for therapeu- tic approaches ...
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CD4 T Cell Depletion at the Cervix during HIV Infection Is Associated with Accumulation of Terminally Differentiated T Cells
... (TD) T cells during HIV infection is associated with CD4 T cell loss and HIV disease ...memory T cells at the cervix. We found that CD4 T cell depletion at the cervix ...
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Alloantigen specific t cell depletion from haematopoietic stem cell grafts for the prevention of graft versus host disease
... delayed T cell reconstitution and depressed T cell function (Keever et ...donor T cells present in the graft (Roux et ...naïve T cells also appear early on either via a thymic or ...
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A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion
... large-scale depletion of T cells during human roseolovirus infection, but to our knowledge, such studies may not have been systematically conducted, and T-cell depletion may occur at a ...
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Impaired CD4 T Cell Memory Response to Streptococcus pneumoniae Precedes CD4 T Cell Depletion in HIV-Infected Malawian Adults
... selective depletion of pneumococcal- specific T cells when compared with immunity to ...memory T cell depletion, including mucosal compartmentaliza- tion of pneumococcal-specific ...
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IL 7 receptor blockade following T cell depletion promotes long term allograft survival
... B cell–deficient muMT mice and treated recipients with the same treatment protocols used in wild-type mice to investigate whether the absence of B cells affects graft ...hand, T cell depletion ...
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Naïve T-Cell Dynamics in Human Immunodeficiency Virus Type 1 Infection: Effects of Highly Active Antiretroviral Therapy Provide Insights into the Mechanisms of Naïve T-Cell Depletion
... CD4 depletion (21, 29, ...CD4 depletion (11, 12), such a hypothesis is inconsistent with the rapid reduction in proliferation of CD4 ⫹ as well as CD8 ⫹ T cells after viral suppression with HAART, ...
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Transient CD4+ T Cell Depletion Results in Delayed Development of Functional Vaccine-Elicited Antibody Responses
... ⴙ T cell help is required at the time of adenovirus (Ad) vector immunization for the development of functional CD8 ⴙ T cell responses, but the temporal requirement for CD4 ⴙ T ...
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Mechanisms of HIV-1-mediated CD4+ T cell depletion in lymphoid tissue
... direct cell death observed in a relevant lymphoid ...host cell membrane (but not CXCR4 binding efficiency) was found to be the most dominant factor that allowed for enhanced pathogenesis by the R3A ...of ...
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High levels of T lymphocyte activation in Leishmania HIV 1 co infected individuals despite low HIV viral load
... + T cells levels in relation to HIV-1 infected patients without ...+ T cell levels, suggesting that activation could also contribute to the T cell depletion ...
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Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large animal model
... vivo T cell–depleting ...without T-cell depletion, bone marrow engraftment could not be achieved in minia- ture swine unless doses of whole-body irradiation (WBI) exceeded 1000 cGy ...
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Understanding the benign nature of SIV infection in natural hosts
... In striking contrast to HIV infection, natural SIV infection of African nonhuman primates is asymptomatic and usually does not induce significant CD4 + T cell depletion despite high levels of virus ...
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Chronic CD4+ T-Cell Activation and Depletion in Human Immunodeficiency Virus Type 1 Infection: Type I Interferon-Mediated Disruption of T-Cell Dynamics
... ⫹ T-cell activation in CD4 ⫹ T-cell ...⫹ T-cell activation would be reflected by transcriptional changes in CD4 ⫹ T cells activated in ...⫹ T cells from untreated ...
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vaccines-04-00030.pdf
... Treg cell development and function, as well as human immunity and immunopathogenesis of HIV-1 ...CD4+ T cell ...Treg cell depletion from humanized mice to determine the role of Tregs in ...
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Distinct roles of CD4+T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model
... + T cells in human health and immunity was dramatically displayed early in the AIDS epidemic as patients presenting with reduced CD4 + T cell counts developed opportunistic ...+ T cells, the ...
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PD L1 serves as a double agent in separating GVL from GVHD
... same T cells and remains a significant clinical problem associated with substantial morbidity and ...+ T cell depletion on GVL versus GVHD and revealed that depletion of CD4 + T ...
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Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells
... regulated cell proliferation was further demonstrated. Cell cycle analysis was per- formed by flow cytometry in U251 cells after TMPO knockdown ...the cell proportion in the G0/G1 phase ...the ...
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