T cell exhaustion
The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1
... (T cell immunoglobulin and mu- cin domain-containing protein 3) is correlated with T cell ex- haustion (23, 30, ...terminates T h 1 immunity (64, ...exhausted T cells is in line ...
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IL 12 upregulates TIM 3 expression and induces T cell exhaustion in patients with follicular B cell non Hodgkin lymphoma
... in T cell exhaustion, via an IFN-γ–indepen- dent ...on T cell ...intratumoral T cells that displayed marked functional ...TIM-3–mediated exhaustion of T cells as a ...
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T cell senescence and CAR-T cell exhaustion in hematological malignancies
... TCR-T cell therapy makes use of functionally active T cells isolated from ...These T cells are reconstructed and expanded ex vivo to recognize specific antigens on target cells and are now ...
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In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors
... impact T cell exhaustion and therapeutic efficacy in distant ...impact T cell exhaustion in distant tumors are questions of significant ...
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IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection
... ⫹ T cell responses play an important role in determining the course of a viral ...⫹ T cell responses, leading to chronic ...⫹ T cell dif- ferentiation state, termed ...
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Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection
... CD8 T cells. The reversal of this functional im- pairment in virus-specific T cells remains an ideal strategy for therapeutic intervention in many chronic infections and tu- ...virus-specific T cells ...
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Immunization with Different Viral Antigens Alters the Pattern of T Cell Exhaustion and Latency in Herpes Simplex Virus Type 1-Infected Mice
... ⫹ T cell response (2, ...⫹ T cell epitope (ITAYGLVL) within the signal sequence of gK ...and exhaustion of CD8 ⫹ T cells in the trigeminal ganglia (TG) of latently infected mice ...
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Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion
... ⫹ T cells, improved functionality of these cells, and enhanced control of viral replication ...⫹ T cells upregulate PD-1 in humans compared to CD8 ⫹ T cells specific for nonpersisting viruses such as ...
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T cell exhaustion: from pathophysiological basics to tumor immunotherapy
... CD8 T cell- mediated immune pathologies during early systemic LCMV infection, showing that T cell exhaustion substan- tially contributes to peripheral tolerance and to moderate immune ...
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Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis
... of T cell exhaustion ...with T cell exhaustion ...decreased T cell IL-7 receptor (CD127) expression, and increased PD-1 and PD-L1 expression on T cells and ...
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Control of Virus-Specific CD8+ T-Cell Exhaustion and Immune-Mediated Pathology by E3 Ubiquitin Ligase Cbl-b during Chronic Viral Infection
... of T-cell tolerance by regulating the ubiquitination and degradation of downstream effectors of T-cell anergy (3, 5, 21, 30, 31, 40, ...mature T cells and play a predominant role in ...
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A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment
... + T and CD4 + T cells also expressed higher levels of immune checkpoints on their surface when com- pared with total splenic CD8 + and CD4 + T cells, suggest- ing that the TME induces ...
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Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
... Whether exhaustion among islet-specific cells of slow pro- gressors precedes disease or is merely a consequence of time and disease duration has important implications for disease mechanisms, monitoring, and ...
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Downregulation of CD73 associates with T cell exhaustion in AML patients
... CD8 T cells express higher frequency of negative receptors such as PD-1, LAG-3, and TIGIT indicate that blocking CD73 may upregulate the inhibitory pathways on CD8 T ...CD8 T cells associates with ...
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Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice
... In term of the function of endogenous HMGN1 within nucleus, Michael Bustin and his colleague reported that lack of endogenous HMGN1 in mouse embryonic fibro- blasts increased the sensitivity to ionizing radiation, and ...
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TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti–PD-1/anti–CTLA-4 immunotherapy
... that T cells in AML have increased PD-1 expression compared with nor- mal ...TSC2-null cell lines, we found that ...of T cells into the tumors. These T cells demonstrated enhanced ...
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The chronic stages of bovine Fasciola hepatica are dominated by CD4 T Cell exhaustion
... CD4 T-cells are suppressive toward autologous responsive counterparts. CD4 T-cells taken from animals’ 2 weeks of postinfection were cocultured with autologous CD4 T-cells isolated from the hepatic ...
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Persistent inflammation and T cell exhaustion in severe sepsis in the elderly
... + T cells from elderly patients and aged mice with severe ...quantify T cell ...CD4+ T cells can be clearly assessed by the decrease in CFSE ...CD4+ T cells from elderly healthy donors ...
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Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion
... CD8 T cell effector ...CD8 T cells was coupled to DNA demethylation of the PD-1 transcrip- tional regulatory region ...CD8 T cells retained the unmethylated PD-1 loci even when the viral load ...
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miR-28 modulates exhaustive differentiation of T cells through silencing programmed cell death-1 and regulating cytokine secretion
... T cell exhaustion is a state of T cell dysfunction that arises during many ...of T cells. We demonstrated that the exhausted T cells with inhibitory receptors (IRs) are ...
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