T-cell homeostasis
Effects of IL 7 on memory CD8+ T cell homeostasis are influenced by the timing of therapy in mice
... + T cell memory, and insufficient IL-7 is believed to limit survival and the persistence of memory CD8 + T ...mouse T cell response to lymphocytic choriomeningitis virus, IL-7 enhanced ...
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Rotavirus Infection Alters Peripheral T-Cell Homeostasis in Children with Acute Diarrhea
... CD8 T lymphocytes in acute-phase PBMC from most ...that T- cell lymphopenia and altered homeostasis of peripheral T lym- phocytes are a common manifestation in children with acute ...
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Quorum-Sensing in CD4+ T Cell Homeostasis: A Hypothesis and a Model
... global T cell pool, including maintenance of the naïve pool and control of the size of the activated T cell ...Treg cell subset extend to all subpopulations on the CD4 + T ...
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Role of Thymic Output in Regulating CD8 T-Cell Homeostasis during Acute and Chronic Viral Infection
... CD8 T-cell responses were compared between mice that were either sham thymec- tomized or thymectomized (Thx) at ⬃ 6 weeks of ...CD8 T cells or the proliferative renewal and maintenance of virus- ...
11
Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers
... different T-cell homeostatic parameters can predict CD4 T-cell loss in ECs by comparing data from EC patients showing significant CD4 decline (cases) and EC patients showing stable CD4 counts ...
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Increased replication of CD4+ naive T cells and changes in T cell homeostasis in a case of acute exacerbation of juvenile idiopathic arthritis: a case comparison study
... heterogeneous T cell- mediated autoimmune ...that T cells play an important role in the pathogenesis of the ...disturbed T cell homeostasis and diminished thymus output, which ...
8
The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT
... in T cell activation and ...direct T-T cell inter- action required for their activation and ...activated T cells and immature dendritic ...purified T cells, suggesting ...
11
T cell homeostasis and systemic autoimmunity
... “bystander” T cells coinjected with a small number of syngeneic T cells (differentiated by allelic markers and intracellular dyes) can inhibit expansion of the latter in a lym- phopenic ...naive T ...
7
Collagen deposition in HIV 1 infected lymphatic tissues and T cell homeostasis
... 21. Schacker, T., et al. 2000. Rapid accumulation of human immunodeficiency virus (HIV) in lym- phatic tissue reservoirs during acute and early HIV infection: implications for timing of anti- retroviral therapy. ...
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CCL17 expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice
... Atherosclerosis is a chronic inflammatory disease of the arterial wall, modulated by immune responses (1). Besides monocytes/ macrophages, other mononuclear cells, namely T cells and DCs, can be detected within ...
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Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation
... Altered cytokine milieu during reconstitution of Tregs and Tcons after allogeneic HSCT. Homeostatic cytokines in plasma were measured at 3, 6, 9, 12, 18, and 24 months after HSCT. (A) Median values (pg/ml) with ...
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Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 inregulating T cell homeostasis
... T cell receptor engagement by peptide- MHC complexes induces the phosphory- lation of immunoreceptor tyrosine-based activation motifs within the intracellular tails of the TCR / CD3 complex by the ...
7
CD28 co-stimulation in T-cell homeostasis: a recent perspective
... Abstract: T-cells play a key role within the adaptive immune system mediating cellular immunity and orchestrating the immune response as a ...the T-cell receptor but in addition co-stimulation via ...
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Wiskott Aldrich syndrome protein is required for regulatory T cell homeostasis
... Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency disorder characterized by opportunistic, viral, and bacterial infections due to abnormal lymphocyte function. Affected individuals also have thrombocytopenia ...
13
Ageing, autoimmunity and arthritis: T cell senescence and contraction of T cell repertoire diversity – catalysts of autoimmunity and chronic inflammation
... the T-cell system. Age-dependent changes in T-cell homeostasis are accelerated in patients with ...memory T cells is less diverse, possibly as a result of thymic insufficiency, ...
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Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation
... effector T cells [9], and the decrease of Th1 and Th17 cells ...B cell activa- tion and differentiation into plasmablasts and immuno- globulin production ...
10
MiStImm: an agent-based simulation tool to study the self-nonself discrimination of the adaptive immune response
... B cell clones are confronted with an overwhelming quantity of soluble self ...B cell receptors (BCRs) will present self peptides in their surface major histocompatibility complex II (MHCII) molecules to ...
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The Role of SLP-76 in the Homeostasis of CD4+ T Cells
... individual cell basis through activation of alternative pathways, for example in response to homeostatic ...individual cell survival is unlikely to account for the divergence seen between turnover and ...
137
CD8+ T cells in beige adipogenesis and energy homeostasis
... agitation. Cell suspension was topped up to 10 ml by DMEM medium and then passed through 100-μm filters to generate single-cell suspensions, before being centrifuged at 300 g for 5 minutes to separate ...
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Naive T cell survival and homeostasis analysis of monoclonal and polyclonal T cell populations
... mature T and/or B ...and T cells for thymic organisation has already been demonstrated (Ritter and Boyd, 1993), but is the structure of peripheral lymphoid organs in congenitally deficient animals disrupted ...
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