T cell immunity
Surface receptor Toso controls B cell–mediated regulation of T cell immunity
... B cell numbers at sites of inflammation and results in impaired T cell responses upon influ- enza ...on T cell immunity, we sought to investigate the effects of anti-Toso ...
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Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans
... cross-reactive T cell responses and the influence of DENV serostatus on T cell immunity to ...preexisting T cell responses against DENV recognize peptide sequences located ...
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Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment
... naive T cell activation without inducing exhaustion marker upregu- lation and without affecting antigen-specific CTL ...on T cell immunity, we evaluated markers for T cell ...
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CD4 T Cells Promote CD8 T Cell Immunity at the Priming and Effector Site during Viral Encephalitis
... D4 T cells play critical roles in controlling viral infections by promoting CD8 T cell responses as well as humoral immu- ...CD8 T cell immunity is elicited prior to production ...
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Pyruvate controls the checkpoint inhibitor PD L1 and suppresses T cell immunity
... anti–PD-L1 antibodies, which rescue the induction of antiviral T cell immunity. Remarkably, aberrant PD-L1 expression on immu- nosuppressive CAD macrophages, a feature shared with cancer cells, is ...
15
APRIL modulates B and T cell immunity
... USA). Cell isolation. T and B cells were purified by negative selection from lymph nodes or spleens using either B220 or ...instructions. Cell populations isolated by this method were at least 95% ...
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AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma
... MA-specific T cell response because MAGE antigens are AIRE-dependent antigens expressed by mTECs [17-21] and have been suggested to be tumor rejection antigens [22, ...MAGEB2-specific T cell ...
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Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity
... squamous cell carcinoma (HNSCC) patients were characterized by increased num- bers of CD39 + Tregs, which hydrolyzed ATP at higher rates, and produced higher levels of adenosine than Tregs from healthy individuals ...
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NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines
... on T cells in the tumors ...depleting cell subsets in vivo ...immune cell influx in the tumor ...CD8 T cells in the tumor at the early relapse phase ...
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Discovering naturally processed antigenic determinants that confer protective T cell immunity
... protective immunity against lethal respiratory VACV infection (10, ...protective immunity. Our strategy, in which fundamental insights into T cell epitope processing and presentation were used ...
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Kunjin Virus Replicon Vaccine Vectors Induce Protective CD8+ T-Cell Immunity
... One particular feature of flaviviruses may prove to be ben- eficial for the use of their replicons as safe vaccine vectors. Flaviviruses, in general, have shown no evidence of recombi- nation between different viruses or ...
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Alteration of T cell immunity by lentiviral transduction of human monocyte derived dendritic cells
... The effect of the IL-10 LV siRNAs was then examined in DCs by co-transduction using a reporter LV and the IL-10 LV-siRNAs. The transduced DCs were then treated with LPS and analyzed for IL-10 expression as described ...
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TNF α is critical for antitumor but not antiviral T cell immunity in mice
... The absence of TNF-α does not alter the kinetics or magnitude of LCMV-induced autoimmune diabetes in RIP-GP or P14/RIP-GP animals. (A) RIP-GP mice were infected with LCMV Arm. Blood glucose levels were measured at ...
14
CD8<sup>+</sup> memory T-cell inflation renders compromised CD4<sup>+</sup> T-cell-dependent CD8<sup>+</sup> T-cell immunity via naïve T-cell anergy
... BL6-10 Ova tumor cells. The mice were killed 3 weeks after the tumor-cell challenge, and tumor-cell lung colonization (tumor colonies) was counted in a blind fashion. Tumor-cell colonies on freshly ...
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MAVS Is Essential for Primary CD4+ T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection
... antigen-presenting cell functions and influencing T cell responses during microbial ...host immunity against the live attenuated West Nile virus (WNV) vaccine strain, the nonstructural (NS) ...
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Role of persistent CMV infection in configuring T cell immunity in the elderly
... CD8+ T cells which accumulate progressively with age resemble CD8+ T cells that are driven to the end-stage of replicative senescence in cell culture in response to repeated rounds of antigen- driven ...
6
Role of IL 17 in HIV specific CD8+T cell immunity
... Data indicated that compared to the control vaccine, IL-13 inhibitor vaccine showed enhanced IL-17 A expression by HIV -specific CD8+T cells at effector stage and following surrogate inf[r] ...
202
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells
... NK cell–mediated killing of virus infected cells can contribute to elimination of viral infections ...NK cell–mediated attack of antiviral T cells can limit T cell immunity (24, ...
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BK Polyomavirus specific T cell immune responses in kidney transplant recipients diagnosed with BK Polyomavirus associated nephropathy
... the immunity during 2–3 weeks period ...BKPyV-specific T cell recovery at each center. Although viral-specific T cell immunity can be measured by various methods, in- cluding ...
8
Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection
... vector-elicited T cell immunity and protection against highly virulent SIV challenge in CMV positive animals ...their T cell targeting phenotype since they elicited CD8 + T cells ...
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