T cell infiltration
Macrophage IFN-I signaling promotes autoreactive T cell infiltration into islets in type 1 diabetes model
... LCMV-specific T cell expansion when P14 T cells are not adoptively trans- ferred into Rip-GP mice prior to infection (Figure ...+ T cell infiltration into the pancreatic islets ...
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Prognostic significance of PD-L1 expression and CD8+ T cell infiltration in pulmonary neuroendocrine tumors
... various cell types including tumors. In both melanoma and squamous cell carcinoma of head and neck (HNSCC), INF-г has been highlighted as a major cytokine driving PD-L1 expression [16, ...CD8+ T ...
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Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB CD8 T-cell infiltration
... of T-cell biomarkers in human cancer has been the focus of much ...type-1 T-cell activity is important for prolonged patient survival [8, ...facilitate T-cell infiltration ...
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CD8/CD45RO T cell infiltration in endoscopic biopsies of colorectal cancer predicts nodal metastasis and survival
... CD8 T-cell infiltration in the preoperative biopsy was significantly associated with favorable overall survival (CD8i p = ...tumor. Infiltration by CD45ROs cells was independently associated ...
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Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy
... of T cells, we sought to examine the impact of therapy on the TRAMP-C2 prostate tumor cells ...tumor cell proliferation was significantly diminished in the remaining hypoxic zones of these cancers ...
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Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy
... as toll like receptor 4 (TLR4) and purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7) [12, 13] and the local expression of genes [such as myxovirus (influenza virus) resistance 1 (MX1)]) that are tied to the ...
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Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice
... In this study, we examined the influence of a peripheral infection with a respiratory pathogen Bordetella pertussis on AD-like pathology in transgenic mice that overexpress amyloid precursor protein (APP) with the ...
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CD4+ follicular helper T cell infiltration predicts breast cancer survival
... S+SN–treated donor cells) suggests that their position and prev- alence within the tumor dictates responsiveness, with extensively infiltrated tumors successfully sequestering higher concentra- tions of leukocytes in ...
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B cell, CD8 + T cell and gamma delta T cell infiltration alters alveolar immune cell homeostasis in HIV infected Malawian adults
... the cell pellet was resuspended and washed with PBS by spinning in a centrifuge at 500g for ...the cell pellet was resuspended in complete ...the cell pellet contained <5% bronchial epithelial ...
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Clinical impact of tumor DNA repair expression and T cell infiltration in breast cancers
... understood, immune effector cells, their cytokine secretions, or cancer cell immunogenicity may influence biology and antitumor response in breast cancer. In addition, chemotherapy-induced Treg depletion, could ...
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Murine Model of Interstitial Cytomegalovirus Pneumonia in Syngeneic Bone Marrow Transplantation: Persistence of Protective Pulmonary CD8-T-Cell Infiltrates after Clearance of Acute Infection
... a T-cell-driven immuno- pathology but is caused primarily by cytolytic infection, with a likely contribution of cytokines and chemokines secreted by infected cells as well as by alveolar macrophages and, ...
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Tissue T and B cell infiltration of primary and metastatic cancer
... lymphocytic infiltration. T cells predominated in the infiltrates in primary tumors (mean 80%, range 50- 100%) and this pattern was evident regardless of anatomic site or the presence or absence of ...
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Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses
... the T cells in long-term survivors with pancreatic cancer target neoantigens ...extensive infiltration are major indicators of favorable patient prognosis and positive therapeutic responses in treating ...
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Ambivalent Role of the Innate Immune Response in Rabies Virus Pathogenesis
... ⫹ T cell infiltration into the RABV-infected NS was ...migratory T cells have been shown to also participate in RABV morbidity (19, 21, 59), both the limited inflammation and ...
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Serum response factor modulates neuron survival during peripheral axon injury
... and T cell activation in axonal ...d.p.i., T cells entered the transected facial nucleus in control infected animals (K; the insert shows individual T cells), but not the intact facial nucleus ...
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Neuroinflammation in Parkinson’s disease and its potential as therapeutic target
... Minocycline is a semi-synthetic, second-generation tetracycline analog, which, as a lipophilic molecule, can easily get through the BBB and has been reported to have anti-inflammatory and neuroprotective properties in ...
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The immune system in sporadic inclusion body myositis patients is not compromised by blood flow restricted exercise training
... stem cell (satellite cell) prolifera- tion and capillary neoformation also seem warranted to gain a deeper understanding of the potential benefits of BFRE intervention in this frail patient ...
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Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models
... lymphocyte infiltration prominently contributes to brain inflammation during the delayed phase of ische- mia, we further compared the brain lymphocyte infiltra- tion in photothrombosis and MCAO mice at 14 days ...
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T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response
... in T cells is dispensable for pathogen response and clearance, but necessary for robust mem- ory recall responses ...sis. T cell responses are critical for controlling JHMV replication within the CNS ...
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Gut microbiota modulate dendritic cell antigen presentation and radiotherapy induced antitumor immune response
... with T cells from OT1 mice. (B) Purified T cells were in vitro–stimulated with aCD3/aCD28 in the presence or absence of 100 μM C4/butyrate in a IFN-γ ELISPOT ...
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