T-cell lymphomas
Clinicopathological Correlation and Outcome in peripheral T cell lymphomas (PTCL): A Retrospective study
... Angioimmunoblastic T cell lymphoma (AITL) (18.5%) and NK/T- cell lymphoma ...large cell lymphomas (ALCL) ...associated T-cell lymphomas (EATL) (4.7%), ...
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Genome-Based Identification of Cancer Genes by Proviral Tagging in Mouse Retrovirus-Induced T-Cell Lymphomas
... The identification of tumor-inducing genes is a driving force for elucidating the molecular mechanisms underlying cancer. Many retroviruses induce tumors by insertion of viral DNA adjacent to cellular oncogenes, ...
7
Tumor progression in murine leukemia virus-induced T-cell lymphomas: monitoring clonal selections with viral and cellular probes.
... To evaluate whether these primary T-cell lymphoma tissues are composed of oligoclonal cell populations and to monitor tumor progression, primary BALB/c and C57BL T-cell lymphomas were tr[r] ...
12
Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
... thymic lymphomas based on its frequent inactivation in T-ALLs, hemizygous- deletion of Bcl11b prevented lethal thymic lymphoma in ~50 % ATM − / − mice and only 2/11 ATM − / − Bcl11b +/ − mice developed ...
5
Selection for c-myc Integration Sites in Polyclonal T-Cell Lymphomas
... Evidence for modulation of c-myc overexpression. Several types of evidence argue that there is selection for particular TBLV insertion sites near c-myc. First, although viruses con- taining four-repeat LTR enhancers ...
13
The c-myc Locus Is a Common Integration Site in Type B Retrovirus-Induced T-Cell Lymphomas
... induces T-cell lymphomas at a lower fre- quency (6, 7, ...MMTV-induced T-cell tumors have acquired new copies of MMTV proviruses in chromosomal DNA in addition to endogenous MMTVs found ...
6
Novel targeted therapies of T cell lymphomas
... T cell lymphomas (TCL) comprise a heterogeneous group of non-Hodgkin lymphomas (NHL) that often present at an advanced stage at the time of diagnosis and that most commonly have an aggressive ...
38
Hematologic toxicity is rare in relapsed patients treated with belinostat: a systematic review of belinostat toxicity and safety in peripheral T-cell lymphomas
... Peripheral T-cell lymphomas (PTCLs) are an aggressive and diverse group of lymphomas with a T-cell ...peripheral T-cell lymphoma, belinostat, histone deacetylase ...
12
Immunophenotyping of Nodal Peripheral T-cell Lymphomas and its Association with Epstein-Barr Virus
... Peripheral T-cell Lymphomas (PTCL) exposes interesting features such as T-cell marker downregulation and paradoxically, the presence of reactive, clustered large- sized CD20 positive ...
8
The diagnosis and management of NK/T-cell lymphomas
... NK/T-cell lymphomas. Plas- macytoid dendritic cell neoplasms, formerly erroneously classified as blastoid NK-cell lymphomas, are localized mainly to the skin but may also involve ...
13
Bendamustine for the treatment of relapsed or refractory peripheral T cell lymphomas: A French retrospective multicenter study
... Between November 2009 and March 2015, 138 PTCL patients were treated with bendamustine in 27 centers. Population median age was 64 (28-89) years with male/ female ratio of 1.4. There were mainly angio-immunoblastic (AITL ...
11
Epstein-Barr virus (EBV) gene expression in EBV-positive peripheral T-cell lymphomas.
... Although the 209-bp product representing EBNA2 mRNA was readily detected in the cDNA preparation from the B95-8 lymphoid cell line, the spliced product representing the EBNA2 mRNA was no[r] ...
6
Vorinostat approved in Japan for treatment of cutaneous T-cell lymphomas: status and prospects
... cutaneous T-cell ...cutaneous T-cell lymphoma but less so against other types of ...cutaneous T-cell lymphoma and other ...
10
Amplification and novel locations of endogenous mouse mammary tumor virus genomes in mouse T-cell lymphomas.
... Transplanted tumors recovered from the same mouse strain and shown to be of independent origin by chromosomal analysis, by the presence of JH immunoglobulin gene rearrangements, or by th[r] ...
10
New molecular insights into peripheral T cell lymphomas
... peripheral T and NK cells (PTCLs) constitute about 12% of all lymphoid neoplasms (see WHO classification 2008 and ...γδ T lymphocytes, elements of the innate immune system, and αβ T cells that ...
9
Recombinative events of the T cell antigen receptor delta gene in peripheral T cell lymphomas
... productive rearrangements could be ascribed to V delta 1J delta 1 joining in 3 cases and VJ delta 1 joining in 2 cases according to the combined pattern of DNA hybridization with the appropriate probes and of cell ...
8
Brentuximab vedotin for treatment of relapsed or refractory malignant lymphoma: results of a systematic review and meta-analysis of prospective studies
... SALCL, T-cell lymphomas, and B-cell lymphomas – we knew that mixing these heterogeneous lymphoma subtypes would make our meta-analysis less valuable, but the final results still showed ...
7
Molecular advances in cutaneous T-cell lymphoma
... Cutaneous T cell lymphomas (CTCLs) are malignancies derived from skin- homing T cells. Mycosis fungoides (MF), the most common CTCL, typically presents with patches and plaques especially on ...
19
Case Report Primary natural killer/T-cell lymphoma of the cervix: a case report and literature review
... NK/T-cell lymphomas have a nasal lesion or disseminated disease, and pure extranasal disease is ...NK/ T-cell lymphoma have been reported in the lit- erature [7, 14, ...
7
Clinicopathological Features of Cutaneous Lymphomas and T-Cell Receptor Gamma Gene Rearrangement Studies in Early Stage Mycosis Fungoides
... Cutaneous lymphomas (CL) are extranodal non-Hodgkin lymphoma of malignant, mature T and B lymphocytes that target the skin and have various distinct clinicopathological entities with varied natural ...
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