T cell receptor for antigen
Identification of a New Tuberculosis Antigen Recognized by γδ T Cell Receptor
... ␥␦ T cells plays an important role in mycobacterial infection. The ␥␦ T cells activated by Mycobacterium tuberculosis-derived nonpeptidic, phosphorylated biometabolites (phosphoantigens) provide only ...
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T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
... ⫹ T-cells Exhibit Substantial Diversity in Their Ability to Recognize Natural Tumor Epitopes—It is established that the ELAGIGILTV and EAAGIGILTV peptides exhibit differential binding to HLA A*0201 (34, ...higher ...
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Antigen-Driven T-Cell Selection in Patients with Cervical Cancer as Evidenced by T-Cell Receptor Analysis and Recognition of Autologous Tumor
... one T-cell population could be potentially “masked” if the same TCR VA or VB family shows a polyclonal composition ...target cell line Daudi or the NK-sensitive target cell line K562 served as ...
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Chimeric antigen receptor-modified T cell therapy in chronic lymphocytic leukemia
... TRUCK T cells [14] and CAR-T with suicide genes [15, ...of T cells in patients and make “off-the-shelf” come true by editing genes of T cell receptor and human leukocyte ...
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CRISPR-Cas, a robust gene-editing technology in the era of modern cancer immunotherapy
... tumor-specific T-cells into patients, a so called “adoptive cell transfer”, or ACT, ...allogeneic T-cells is dependent on the employment of a gene-editing tool to modify donor-extracted ...
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Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
... of T lymphocytes that contains clones responsive to tumor ...renal cell carcinoma (2) and glioma (3), it is not broadly applicable to multiple cancer types because of the low fre- quency of TILs within the ...
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Molecular analysis of the helper T cell response in murine interstitial nephritis T cells recognizing an immunodominant epitope use multiple T cell receptor V beta genes with similarities across CDR3
... target antigen, 3M-1. Evaluation of the T cell receptor (TCR) V beta repertoire used by these autoreactive T cells reveals the use of several V beta genes, but with some preference for ...
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Detection of monoclonal immunoglobulin heavy chain gene rearrangement (FR3) in Thai malignant lymphoma by High Resolution Melting curve analysis
... of antigen receptor gene rearrangement including T cell receptor (TCR) and immunoglobulin heavy chain (IgH) by polymerase chain reaction followed by heteroduplex has currently become ...
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Bias toward use of a specific T cell receptor beta chain variable region in a subgroup of individuals with sarcoidosis
... of T cell antigen receptor beta variable (V) regions may be manifested in T lymphocytes that accumulate in nonmalignant, T cell- mediated human disorders, a V beta ...
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Critical factors in chimeric antigen receptor-modified T-cell (CAR-T) therapy for solid tumors
... Unlike the intravenously infused CAR-T co-circulation with cancer cells in hematological cancers, a solid tumor has a hostile TME which presents a major hurdle in the CAR-T exertion effect. The TME is ...
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Structure and function of the T cell antigen receptor
... This has been further supported by more recent experiments in which a heterologous receptor that activates the inositol phospholipid pathway, the human muscarinic receptor subtype 1, whe[r] ...
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CAR-T “the living drugs”, immune checkpoint inhibitors, and precision medicine: a new era of cancer therapy
... bispecific T cell engagers, and antibody- drug conjugates make the antibody-directed agents more powerful with less ...for T cells have led to the revolution of modern cancer ...chimeric ...
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<p>Coexistence Of A Huge Venous Thromboembolism And Bleeding Tendency In Cytokine Release Syndrome During CAR-T Therapy</p>
... Abstract: Chimeric antigen receptor (CAR)-modi fi ed T cell therapy is increasingly adminis- tered for hematological malignancies. Cytokine release syndrome (CRS) is a common and severe ...
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From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma
... adoptive cell immunotherapy, which uses chimeric antigen receptor-modified T cells (CAR-T) or genetically modified NK cells, has been shown to be a promising strategy for the treatment ...
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Cancer biomarkers for targeted therapy
... bispecific T cell engagers, and antibody-drug ...B cell maturation antigen, and CD138 are targets for cancer immunotherapeutic agents, including the chimeric antigen receptor - ...
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Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases
... resting T cells, CD45 may counteract the neg- ative regulation of Csk by dephosphorylating the nega- tive regulatory, and to a lesser extent the autocatalytic, tyrosine in SFKs, providing a pool of ...
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Molecular characterisation of the T-cell receptors expressed in rheumatoid arthritis patients
... Structure of T cell antigen receptor fi chain in synovial fluid cells from patients with rheumatoid arthritis.. Elevation of a 10 T cell subset in peripheral blood and synovial fluid of [r] ...
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Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1.
... Although it remains possible that stimulation of the T-cell antigen receptor may indirectly activate T-cell gene products, for example, tumor necrosis factor alpha, which activate the HI[r] ...
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Metabolic communication in tumors: a new layer of immunoregulation for immune evasion
... tumor antigen-specific T cells due to clonal deletion; 2) poor activation of innate immune cells and accumulation of tolerigenic antigen-presenting cells in the tumor microenvironment; 3) formation ...
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MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells
... Then, T cells were collected from a healthy donor, activated by CD3/ CD28, expanded by IL-2 and transfected by mCAR lenti- virus to produce mCART, which showed high transfec- tion efficiencies and appropriate ...
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