T cell receptor signaling
HIV-1 Nef: a multifaceted modulator of T cell receptor signaling
... which T-lymphocyte hyperactivation and sub- sequent depletion was observed ...ger T-cell receptor signaling and IL-2 production by virtue of an ITAM motif not present in any other Nef ...
11
T cell receptor signaling for γδT cell development
... γδΤ17 cell phenotype at the expense of the γδΤ1 cell phenotype ...γδT1 cell development also requires costimulation via CD27, a TNF receptor superfamily protein expressed in γδT1 cells, but ...
11
Role of cytoskeletal remodeling in T cell receptor signaling and integrin activation at the immunological synapse
... The above-mentioned models are not mutually exclusive and could be mechanically linked. The assembly of MCs in the presence of a flowing cytoskeleton suggests that the cytoskeleton can provide a transient scaffold, a ...
244
Regulation of T Cell Receptor Signaling by Diacylglycerol Kinases and Phosphatidylinositol Transfer Proteins
... intracellular signaling domain (Curran et ...productive signaling from CARs allows appropriate cellular activation, cytotoxicity, and persistence to specific tumor antigens, and how to induce productive ...
155
Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling
... intrathymic T cell devel- opment and TCR-mediated signaling in the ...TCR signaling and enhanced thymocyte ...TCR signaling in developing thymocytes may block positive selection ...
12
Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus.
... In T cells, stimulation of TCR triggers the phosphorylation of both tyrosine residues on the ITAM from the TCR, and the phosphorylated ITAM pro- vides the binding site for a T-cell-specific tyrosine ...
7
Viral Modulation of T-Cell Receptor Signaling
... Since T cells represent the main site of HIV replication in vivo, per- haps it should not be surprising that HIV is a talented manip- ulator of T-cell ...TcR signaling is to ...
11
Inappropriate costimulation and aberrant DNA methylation as therapeutic targets in angioimmunoblastic T-cell lymphoma
... of T cell receptor signaling or costimulatory pathways, other than RHOA ...Ras/Raf/MAPK/ERK signaling pathways were ...in T cell receptor signaling or costi- ...
8
Oncogenic Protein Kinase D3 Regulating Networks in Invasive Breast Cancer
... tumor cell transformation of colon cancer and modulate cancer related STAT-β-catenin pathway ...of T cells through the T cell antigen receptor (TCR) is essential for thymocyte ...
11
Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in tourette syndrome: a pilot study
... IL-4 Signaling, B cell receptor sig- naling, T cell receptor signaling, and glucocorticoid receptor ...with cell death, behav- ior, as well as nervous system ...
8
Defective expression of p56lck in an infant with severe combined immunodeficiency
... 1 T cells. T cells from this patient showed poor blastogenic responses to various mitogens and ...Other T cell antigen receptor– induced responses, including upregulation of CD69, were ...
10
CISH promoter polymorphism effects on T cell cytokine receptor signaling and type 1 diabetes susceptibility
... on T cell function during allergic, malignant, and infectious diseases ...regulated T cell activation and polarization of CD4 + and CD8 + T cells [12, ...increased T REG function ...
8
T cell receptor (TCR) transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFβ) signaling mediate superior tumor regression in an animal model of adoptive cell therapy
... TGFβ receptor complex, intracellular kinase do- main phosphorylates SMAD2 and SMAD3 protein, which translocate to the nucleus along with SMAD4, forming a complex that regulates gene ...intracellular ...
8
Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy
... cancer cell lines, AKT is capable of phosphorylating FOXO1 at these sites, causing cytoso- lic sequestration and preventing DNA binding ...human T cells, we performed confocal immunofluorescence imaging of ...
18
Recent Advances in T Cell Signaling in Aging
... activated T cell) regulatory sequence or the whole IL-2 promoter ...stimulated T cells ...in T cell signaling re- mains ...antigen receptor is a 95 kDa protein known as ...
13
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
... in T cell development and function and contribute to both the promo- tion and attenuation of T cell ...the receptor type PTP CD45 is required for Lck activation and the promotion of TCR ...
18
Using random walks to identify cancer-associated modules in expression data
... dataset: cell-cycle control, DNA replication/repair, cellular adhesion/migration, apoptosis, angiogenesis, evasion of the immune response and ...with cell cycle control, growth signaling, focal ...
25
The CD4 Receptor: An Indispensable Protein in T Cell Activation and A Promising Target for Immunosuppression
... in T cell activation, the CD4 receptor is suggested to be involved in peripheral T cell differentiation towards the Th2 ...+ T cells were activated in vitro in the presence of a ...
18
Antigen receptor signaling in the rheumatic diseases
... that T-cell hyper-respon- siveness can also break tolerance may be the Cbl/Cbl-b double-deficient ...antigen receptor signal transduction machinery for degradation, Cbl and Cbl-b serve as negative ...
9
A CD4+T cell antagonist epitope down regulates activating signaling proteins, up regulates inhibitory signaling proteins and abrogates HIV specific T cell function
... of T cell signaling, including STAT-3 and −5 phosphorylation, at early time points with either Ag or Ag + Ant treatment supports delivery of an early activation ...However, signaling is only ...
16