T cell receptors
Activating interactions of sulfanilamides with T cell receptors
... reactive T cells are key features in drug hypersensitivity ...mune receptors such as the human leukocyte antigens (HLA) or the T-cell receptors (TCR) it- self, the pharmacological ...
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MHC restricted fratricide of human lymphocytes expressing survivin specific transgenic T cell receptors
... adoptive T cell therapy using lymphocytes expressing survivin-specific transgenic T cell receptors (Tg-TCRs), we isolat- ed HLA-A2–allorestricted survivin-specific T cells with ...
10
Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq
... Quality control was performed (“Methods” and Additional file 1: Table S1) and 71 samples were subsequently se- lected for processing in scTCRseq (with BLAST eValue threshold 1e-8, minimum supporting read coverage 5, and ...
12
Selective expansion of specific T cell receptors in the inflamed colon of Crohn's disease
... apy. Furthermore, since LPL from disease-active and disease- inactive tissues were derived from adjacent surgical specimens, we minimized repertoire differences that might be caused by cellular compartmentalization, such ...
12
A DOCK8 WIP WASp complex links T cell receptors to the actin cytoskeleton
... 4°C. T cells were adhered to anti-CD3–coated coverslips by centrifugation at 280 ×g for 5 minutes at 4°C, stimulated for 30 minutes at 37°C, and mechanically unroofed with poly-L-lysine–coated covers- lips in PHEM ...
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Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies
... + T cells [12]. Using this method, we isolated numerous multimer + CD8 + T cell clones, however, a significant number of these showed no reactivity against relevant peptide-loaded LCLs, demonstrating ...
14
Public T cell receptors confer high avidity CD4 responses to HIV controllers
... This study was carried out in the framework of the ANRS EP36 HIV Controllers Study Group. We are grateful to the patients who partici- pated in the study. We thank the clinicians who recruited patients for this study: ...
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Molecular characterisation of the T-cell receptors expressed in rheumatoid arthritis patients
... Structure of T cell antigen receptor fi chain in synovial fluid cells from patients with rheumatoid arthritis.. Elevation of a 10 T cell subset in peripheral blood and synovial fluid of [r] ...
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Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells
... Isolation of blood mononuclear cells and tumor-infiltrating cells. Tissue and blood samples were collected from mel- anoma patients (clinical characteristics in Table 1) by the Tissue Resource Core of the Yale SPORE in ...
14
Structure and specificity of T cell receptors expressed by potentially pathogenic anti DNA autoantibody inducing T cells in human lupus
... autoimmune T helper (Th) cells. Herein, we sequenced the T cell receptor (TCR) alpha and beta chain genes expressed by 42 autoimmune Th lines from lupus patients that were mostly CD4+ and represented ...
12
Immune parameters to consider when choosing T-cell receptors for therapy
... of T-cell alloreactivity in the context of TCR therapy is to perform preliminary in vitro screens of the TCR for cross-recognition of cell lines expressing a wide range of allo-HLA ...alloreactive ...
6
Single-cell analysis of glandular T cell receptors in Sjögren’s syndrome
... of T cells or germinal center-like structures in oral symptoms has been ...SG T cell clonal expansion (data not ...CD4 T cells and measures of SG dysfunction and tissue ...SG T cells ...
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Molecular analysis of T cell receptors: Mapping T cell recognition and repertoire in two human immune responses
... specific T cells can be readily isolated from both atopic and non - atopic subjects, they show a m arked difference in their cytokine ...specific T cells from atopies are Th2-like, produce IL-4 and IL-5, ...
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Allorecognition by T Lymphocytes and Allograft Rejection
... recipient T cells in secondary lymphoid organs initi- ates the adaptive inflammatory immune response leading to the rejection of allogeneic ...Allospecific T cells become activated through interaction of ...
10
Degeneracy, as opposed to specificity, in immunotherapy
... human T cell clones can also be induced to secrete the antiinflamma- tory cytokines IL-4 and TGF- β after T cell receptor engagement by APLs (13, ...MBP-reactive T cells isolated from ...
5
Roles of antigen receptors and CA215 in the innate immunity of cancer cells
... single cell, it was first observed that the genes of antigen receptors, including those of immu- noglobulins and T cell receptors (TCRs), were expressed among several different cancer ...
12
Giant Cell Vasculitis Is a T Cell-Dependent Disease
... cells with identical T cell receptors were expanded in different mice that had been engrafted with tissue frag- ments from the same patient, indicating that T cell sur- vival in the arte[r] ...
14
Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse
... isolated T cell responders, purified populations of macrophages were added to the ...resulting cell popula- tion was highly enriched for macrophages as determined by cytofluorometry with MAC-1 and ...
8
Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies
... Cognitive function was measured using Mini- mental State Examination (MMSE) validated in local Singaporean elderly [54]. Presence of medical disorders was ascertained by the subjects’ self-report of a doctor’s diagnosis ...
13
The structure and function of human phosphoinositide 4-kinases
... The finding that Ptdlns 4Kp is sensitive to PI 3-kinase inhibitors is important because it calls the specificity of such reagents into question. Wortmannin has been a valuable tool in dissecting PI 3-kinase function ...
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