T-cell reconstitution
Frequency analysis of TRBV subfamily sjTRECs to characterize T-cell reconstitution in acute leukemia patients after allogeneic hematopoietic stem cell transplantation
... diverse T-cell repertoire is dependent on thy- mic production of T cells from hematopoietic progeni- ...that T-cell reconstitution was due rather to post-thymic ...
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Interleukin-27 promotes CD8+ T cell reconstitution following antibody-mediated lymphoablation
... stem cell trans- plantation, and autoimmunity ...memory T cells appear to be more resistant to depletion, having been observed in transplant recipients treated with ATG or anti-CD52 mAb (CAMPATH-1) in ...
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IL 7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation
... apoptotic T cells in the periphery than do healthy controls, and this was associated with GVHD, human leukocyte antigen disparity, time after transplant, and the expression of Fas and Bcl-2 (73, ...peripheral ...
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T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection
... + T cell lymphopenia (<100 cells/mL) at the initi- ation of treatment, often in the presence of an identifiable ...using T-cell repopulation of lymphopenic murine hosts harboring ...
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Peptide vaccination in the presence of adjuvants in patients after hematopoietic stem cell transplantation with CD4+ T cell reconstitution elicits consistent CD8+ T cell responses
... ALL: Acute lymphoblastic leukemia; AML: Acute myeloid leukemia; ATG: Anti-thymocyte globulin; BM: Bone marrow; Bu: Busulfan; (c)GvHD: (Chronic) Graft-versus-host disease; CLL: Chronic lymphocytic leukemia; CMML: Chronic ...
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CD4+ T-Cell Reconstitution Reduces Cytomegalovirus in the Immunocompromised Brain
... ⫹ T cells might play a pivotal role in combating CMV infection (19, ...⫹ T cells were the major effector cells against virus within the ...of T-cell subsets was done using negative selection ...
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Analysis of the adult thymus in reconstitution of T lymphocytes in HIV 1 infection
... peripheral T-cell reconstitution in thymec- tomized patient ...peripheral T cells and not from new cells from a thymus, then analysis of the TCR repertoire during HAART treat- ment would be ...
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Extrathymic development of murine T cells after bone marrow transplantation
... Restoring T cell competence is a significant clinical challenge in patients whose thymic function is severely compromised due to age or cytoreductive ...extrathymic T cell development in ...
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Rapid reconstitution of CD4 T cells and NK cells protects against CMV reactivation after allogeneic stem cell transplantation
... antigen-specific T-cell responses is often elaborate and patient-specific reagents are needed, a more general measure for immune reconstitution, including absolute cell counts, would be ...
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Immune reconstitution of HLA A*0201/BMLF1 and HLA A*1101/LMP2 specific Epstein Barr virus cytotoxic T lymphocytes within 90 days after haploidentical hematopoietic stem cell transplantation
... and T cell reconstitution and arrived at a similar conclusion, demonstrating that the effective- ness of preemptive intervention may be limited in patients who lack EBV-specific T cell ...
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Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients
... CD3+ T cell reconstitution was delayed with persistent CD4+ T cell ...B cell levels were inversely associated with clinical response, suggesting that pathogenic B cell ...
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Human Cytomegalovirus Specific T Cell Immune Reconstitution in Preemptively Treated Heart Transplant Recipients Identifies Subjects at Critical Risk for Infection
... of T-cell immune reconstitution and a higher incidence of late-onset CMV disease (3, 5, 17, 21, ...antiviral T- cell immune reconstitution ...immune reconstitution. Thus, ...
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Reconstitution of hepatitis B virus (HBV)-specific T cell responses with treatment of human immunodeficiency virus/HBV coinfection
... CD8 cell specificities in secondary lymphoid organs during treatment with lamivudine in HIV-negative pa- tients with HBV infection [6] suggests the potential for a more complete reconstitution of the ...
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Cytokine Modulation of Thymopoiesis
... requires T cells to respond to an infinite number of antigens without attacking the ...of T cells that ensures the selection of a diverse TCR repertoire able to react with foreign peptides and have a ...
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Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults.
... + T-cell immunity and naturally-acquired influenza-specific antibody responses in HIV-infected ...+ T-cells and not influenza-specific CD8 + T cells were associated with lower virus shedding ...
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Original Article Reconstitution and clinical significance of T cell subsets in the early stage after related HLA-mismatched peripheral blood hematopoietic SCT without T-cell depletion in vitro
... matured T lymphocytes, so it would affect the engraftment and increase the risk of GVHD occurrence after RHNT-PSCT [10, ...of T lymphocyte subsets, and primarily investigating the relationship between the ...
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HIV-Associated Cryptococcal Immune Reconstitution Inflammatory Syndrome is Associated with Aberrant T Cell Function and Increased Cytokine Responses
... compared circulating T cell memory subsets and cytokine responses among 17 HIV-infected 30.. Ugandans with CM: 11 with and 6 without CM-IRIS.[r] ...
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Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft versus host disease
... Regulatory T cells (Tregs) have been shown to enhance immune reconstitution and prevent graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation; however, it is unclear how ...
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PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice
... for T cell activation. Thus, absence of PKCθ selectively impairs T cell activation by low-level and low-affinity TCR ...allow T cell activa- tion by lower-affinity antigens ...
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High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor(-)/CD52(-) T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell-Depleted Allogeneic Stem Cell Transplantation
... progenitor cell carrying a single PIGA mutation that generally affects multiple hematopoietic cell ...GPI/CD52-negative cell populations found in ALM-based T-cell depleted alloSCT ...
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