T cell repertoire
The LCMV gp33-specific memory T cell repertoire narrows with age
... specific T cell ...the repertoire is stable for seven months and only begins to contract after that ...in repertoire complexity is not ...LCMV repertoire as a result of infection with ...
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Characterization of T cell repertoire in patients with graft versus leukemia after donor lymphocyte infusion
... b repertoire was that all four patients displayed a markedly skewed Vb repertoire in peripheral T cell samples obtained before ...Vb repertoire was characterized by multiple clonotypic ...
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Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide
... PB T cell repertoire is quite clonal during the first posttrans- plant year and remains so for multiple years after ...like repertoire apparently deriving from the donor memory ...recipient ...
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Host Ethnicity and Virus Genotype Shape the Hepatitis B Virus-Specific T-Cell Repertoire
... HBV-specific T-cell responses present in patients with HBV infection, but these variables shape distinct HBV-specific T-cell ...CD8 T-cell repertoire of ethnically ...
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Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire
... the T-cell repertoire during human cytomegalovirus (CMV) infection and demonstrate that primary co-infection with genetic variants of CMV was coincident with development of strain-specific ...
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Stochastic competitive exclusion in the maintenance of the naïve T cell repertoire
... The T cell repertoire exhibits a large diversity of its antigen receptors (TRCs); a human possesses approxi- mately 10 7 − 10 8 TCRs (Arstila et ...the T cell maturation process ...
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Organ specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide
... to T cells through polymorphism at the pep- tide-binding groove (11–15), it has been postulated that efficient binding of organ-specific self-peptides by dis- ease-associated MHC molecules leads to T ...of ...
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A new mechanism shapes the naïve CD8+ T cell repertoire: the selection for full diversity
... TCR repertoire unique to each mice (Turner et ...“public” T cell response, in which multiple individuals sharing identical in responding to a same pMHC epitope, giving a much more limited TCRB ...
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The Cytomegalovirus-Specific CD4+ T-Cell Response Expands with Age and Markedly Alters the CD4+ T-Cell Repertoire
... CD4 T cells and a profound alteration of the global T-cell ...CD4 T cells to stimulation in vitro with superan- ...of T cells that pro- duced IL-2 in response to superantigen, and while ...
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Decline of influenza-specific CD8+ T cell repertoire in healthy geriatric donors
... functional T cell repertoire are also known to occur in cytomegalovirus (CMV)-specific T cell responses in the geriatric ...+ T cell diversity and their immune response to ...
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Recall T cell responses to bluetongue virus produce a narrowing of the T cell repertoire
... bulk T cell responses corre- late weakly with the control of virus replication, whereas T cell responses to subdominant epitopes can play an important role in limiting infection [42, ...of ...
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Reduced T cell repertoire restrictions in abatacept treated rheumatoid arthritis patients
... Figure 2 Analysis of T-cell repertoire. TCRBV chain perturbations were determined by CDR3 spectratyping analysis in samples of RA patients, obtained before (T0) and after 12 months (T12) of ABA ...
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T cell repertoire remodeling following post transplant T cell therapy coincides with clinical response
... adoptive T cell therapy (ACT) approach to restore immunological control in patients with CMV compli- ...CMV-specific T cells using a customized peptide pool containing 30 HLA class I and ...
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Microchimerism maintains deletion of the donor cell–specific CD8+ T cell repertoire
... donor cell–specific T cell rep- ertoire required the engrafted cells to be experimentally ...donor cell–specific T cell repertoire as the responsible mechanism of CTL ...
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Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection
... of T-cell sequencing in the transplant field has been increasingly ...and T cell re- sponse to different viral infections using NGS-DNA- based platform demonstrated the feasibility of tracking ...
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Specific T cell activation in an unspecific T cell repertoire
... negatively-selecting cell, and (ii) its presentation level, ...naïve T-cells in the mature TCR repertoire, as illustrated in Figure 7: the thymic presentation level determines the truncation point of ...
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Molecular characterization of T cell receptor beta variable in the peripheral blood T cell repertoire in subjects with active tuberculosis or latent tuberculosis infection
... + T-cell cytokine profiles in peripheral blood [41], and Nemeth, et ...the T cell response to a recom- binant and methylated heparin-binding haemagglutinin (HBHA) of MTB produced in ...+ ...
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Nondeletional T-Cell Receptor Transgenic Mice: Model for the CD4+ T-Cell Repertoire in Chronic Hepatitis B Virus Infection
... rHBeAg and synthetic peptides. An Escherichia coli-derived rHBeAg corre- sponding in sequence to serum-derived HBeAg encompassing the 10 precore amino acids remaining after cleavage of the precursor and residues 1 to 149 ...
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Ageing, autoimmunity and arthritis: T cell senescence and contraction of T cell repertoire diversity – catalysts of autoimmunity and chronic inflammation
... naive T cells that lack any features of regulatory cells but that have the potential of homeostatic ...clonal T-cell populations can selectively inhibit the division of T cells of their own ...
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T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
... the T-cell response in comparison with the native antigen (33, ...best T-cell ...⫹ T-cell ...mobilized T-cell pop- ulation with respect to recognition of the ...
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