T(D)CDD
Acute Exposure to TCDD Increases Liver Disease Progression in Mice With Carbon Tetrachloride-Induced Liver Injury
... Although TCDD induces the transcription of Cyp1a1, TCDD is not a viable substrate for this enzyme and therefore cannot be ...of TCDD within cells, which can be up to ten days in hepatocytes ...
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Exposure to the Environmental Endocrine Disruptor TCDD and Human Reproductive Dysfunction: Translating Lessons from Murine Models
... In addition to the consequences of industrialization, human toxicant exposures have long been associated with military service. During the American war in Vietnam, thousands of pounds of the highly toxic herbicide and ...
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Long Term Fate of Agent Orange and Dioxin TCDD Contaminated Soils and Sediments in Vietnam Hotspots
... Agent Purple was a patented mix of 50% butyl D and 50% butyl T with the T component including butyl and isobutyl esters. However, the most commonly used herbicide was Agent Orange, a synthetic growth regulator consisting ...
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Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells
... the TCDD-treated cells and control AEC using an RNA extraction solution ...of TCDD-treated cells and the control AEC using an oligo-dT primer with a T7-pro- moter sequence at the ...
9
Consequences of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on Hepatic Stellate Cell Activation and Extracellular Matrix Remodeling During Chronic Liver Injury
... for TCDD toxicity. For example, TCDD is known to decrease vitamin A storage in the liver, which supports the notion that TCDD may modulate the ability of HSCs to regulate retinoid homeostasis ...
117
Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels
... CYP1B1, a cytochrome P450 (CYP) enzyme, was the most highly expressed CYP gene in human brain micro- vessels [1]. Expression of genes encoding CYP enzymes is regulated in several peripheral tissues by transcription ...
12
Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study
... Prenatal TCDD exposure was examined in two ways: 1) maternal initial (1976) serum TCDD level and 2) esti- mated TCDD at ...Initial TCDD levels were assessed to examine whether the primary dose ...
9
Learning behavior in rat offspring after in utero and lactational exposure to either TCDD or PCB126
... low TCDD dose that did not affect the dams did disrupt the offspring’s learning behavior when the offspring was challenged by various behavioral tests, such as matching-to-sample learning tasks in monkeys [19], a ...
12
Rat Peripheral Blood Lymphocytes as a Surrogate for Expression of TCDD Inducible Genes
... determining TCDD inducibility in correlation with tissues using conventional RT-PCR due to the high sample requirement for a statistically significant number of data ...
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Assessing ecotoxicological effects of 2,3,7,8-TCDD, 1,2,3,7,8-PeCDD, and 2,3,4,7,8-PeCDF in soil using Allivibrio fischeri
... and biomagnification occurs through the food chain. The toxic effects of dioxins and dioxin-like compounds are determined relative to a reference compound, usually 2,3,7,8-tetrachlorodibenzo-p-dioxin ...
6
<p>TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP), A Novel Therapeutic Target Of Breast Cancer</p>
... To further evaluate the priority targets above, we chose TIPARP (TCDD-inducible poly-ADP-ribose polymerase) as a promising drug target in breast cancer and performed con fi rmatory studies for it. TIPARP is a ...
14
A dispersion model for the hepatic uptake and elimination of TCDD
... of TCDD in animals have generally used the \well-stirred" or \venous-equilibrium" model to describe events occurring in the liver [6, ...of TCDD, including TCDD-binding to the Ah receptor ...
24
In Utero Exposure to 2,3,7,8 Tetrachlorodibenzo p Dioxin Affects the Development of Reproductive System in Mouse
... utero TCDD exposure on expression of androgen ...μ TCDD concentration on GD ...from TCDD exposed group on PND 30 and PND 60 (Magnifi- cation: × ...day; TCDD, ...
8
Aryl Hydrocarbon Receptor-Mediated Inhibition of Osteogenesis in a Teleost Model In Vivo and Human Mesenchymal Stromal Cells In Vitro.
... nM TCDD due to a high rate of survivorship to 20 dpf (larval stage) of 85 ± 11% and 49 ± 24%, ...nM TCDD demonstrated gross skeletal morphological deficits including dorsalization of the tail, a truncated ...
258
1253.pdf
... contamination of 2,4,5-T ranged from 1 to 70 ppm; the Council of Scientific Affairs reported in 1982 that this contamination has been regulated at less than 0.01 ppm. The infamous herbicide Agent Orange consisted of a ...
45
Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study
... to TCDD, EMSA experiments were performed against the candidate ...Because TCDD-activated AhR translocates into the nucleus with ARNT and binds to DNA, EMSA was per- formed in the presence of AhR and ARNT ...
11
Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells: an immunotoxicology study
... Perhaps the best studied stromal cell-blood cell interac- tion is that which occurs between bone marrow stroma and developing B lymphocytes [6-9]. Of particular interest in these studies is the contribution of stromal ...
13
<p>Aryl hydrocarbon receptor acts as a tumor suppressor in a syngeneic MC38 colon carcinoma tumor model</p>
... low TCDD-dependent cyp1a1 expression when compared to Hepa1c1c7 cells, suggesting that the receptor, which is detectable by Western analysis (data not shown), might not be ...
16
Dulich, Felix (2009): N-Myristoyltransferase 2-abhängig induzierbare Myristoylierung von PRS4, p22 und Gai2. Dissertation, LMU München: Fakultät für Biologie
... Diese Ergebnisse deuten darauf hin, dass es in 5L-Zellen einige myristoylierte Proteine gibt, u. a. die hier identifizierten, deren Myristoylierungsstatus durch TCDD induzierbar ist, während er bei anderen ...
134
The protective action of tocopherol and acetylsalicylic acid on the behavior of rats treated with dioxins
... of TCDD connected with generating a large number of free radicals, TNF and pros- taglandins which affect the functioning of the CNS, induce depression, apathy and lethargy ...
10