T helper
Identification of global regulators of T-helper cell lineage specification
... CD4+ T cells [29]. Additionally it has binding sites for both GATA-3 and T-bet, master transcription factors for Th1 and Th2 cells where T-bet induces and GATA-3 inhibits the transcription of the ...
11
Multiple myeloma presenting as cutaneous leukocytoclastic vasculitis and eosinophilia disclosing a T helper type 1/T helper type 2 imbalance: a case report
... a T helper type 1/T helper type 2 imbalance and T regulatory cells, and was successfully treated with bortezomib, lenalidomide, and ...
6
T Helper 1/T Helper 2 Cytokine Imbalance in Respiratory Syncytial Virus Infection Is Associated With Increased Endogenous Plasma Cortisol
... ⫹ T cells. These lymphocytes can be subdivided into 2 subsets, T helper 1 (Th1) and Th2, on the basis of the cytokine profiles they ...1 T cells produce interferon ␥ (IFN- ␥ ), an essential ...
11
Induction of rabies virus-specific T-helper cells by synthetic peptides that carry dominant T-helper cell epitopes of the viral ribonucleoprotein.
... To determine whether RNP-specific T-helper cells cross-reacted with the RNP or N protein from different rabies or rabies-related viruses, BALB/c mice were immunized with ERA BPL s.c., an[r] ...
8
The Newly Identified T Helper 22 Cells Lodge in Leukemia.
... + T cells in the pathogenesis of ...patients, T helper (Th) type 1 cells are significantly decreased in newly-diagnosed or relapsed/refractory patients compared with complete remission or healthy ...
12
Decreased T helper 17 cells in tuberculosis is associated with increased percentages of programmed death ligand 1, T helper 2 and regulatory T cells
... conclusion and performing regression analysis were not possible. Second, patients had comorbidities of cancer and diabetes mellitus were included and the disease spectrum was heterogeneous Both factors might have ...
8
Transcriptional Regulation of T Helper 17 Cell Differentiation
... of T helper subsets, Th17, has recently been identified as an IL- 17-producing CD4+ Th cell, and its functions and regulatory mechanisms have been extensively characterized in immune ...γ t, IRF4, ...
8
Individual T helper cells have a quantitative cytokine memory
... more T-bet mRNA and protein than their IFN-γ lo and IFN-γ – counterparts ...between T-bet and IFN-γ expression in fully committed Th1 cells at the single-cell level by coexpression ...more T-bet ...
71
Identification of a T-helper cell epitope on the rotavirus VP6 protein.
... that are relevant for protection. Moreover, particular attention must be paid to heterotypic responses, since in humans there are at least four different epidemiologically important rota- virus G serotypes (35). The ...
8
T helper subset development: roles of instruction, selection, and transcription
... of T cells, in contrast, are not well ...precommitted T cells, or the instructive actions of cytokines on naive uncommitted T cell pre- cursors ...naive T cells may already be clonally ...
6
Cytokines and T Helper Cells in Diabetic Nephropathy Pathogenesis
... Diabetic Nephropathy (DN) is considered the main cause of end stage kidney disease around the world. However, its pathogenesis is not completely established. More than just a direct consequence of chronic glycemic ...
17
T cell receptor independent immunosuppression induced by dexamethasone in murine T helper cells
... The immune and inflammatory responses are largely inhibited by glucocorticosteroids. In thymocytes, for example, glucocorticosteroids cause apoptosis, whereas they suppress the activity of phospholipase A2 and the ...
6
T-helper 1 versus T-helper 2 lymphocyte immunodysregulation is the central factor in genesis of Burkitt lymphoma: hypothesis
... Malaria and malnutrition, both very common in Equato- rial Africa, are thought to play part in the immunological events leading to lymphomagenesis [10-12]. Specifically, Malaria is known to alter cytokine production ...
5
Alveolar T helper 17 responses to streptococcus pneumoniae are preserved in ART untreated and treated HIV infected Malawian adults
... HIV-1-infected participants were divided into two sub- groups based on whether they were on ART or not at the time of recruitment. First line ART consisted of stavudine, lamivudine, and nevirapine, or tenofovir, ...
9
Plasma levels of monokine induced by interferon-gamma/chemokine (C-X-X motif) ligand 9, thymus and activation-regulated chemokine/chemokine (C-C motif) ligand 17 in children with Kawasaki disease
... AST: Aspartate aminotransferase; C: Cys; CAA: Coronary artery aneurysm; CAL: Coronary artery lesions; CC: Cys-Cys; CK-MB: Creatine kinase-MB; CRP: C-reactive protein; CXC: Cys-X-Cys; CX3C: Cys-X-3Cys; EDTA: Ethylene ...
6
Disrupted balance of CD4+ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia
... of T helper 22 (Th22), Th17, Th1, Th2, follicular T helper (Tfh) cells and regulatory T cells (Tregs) as well as their effector cytokines in BM and PB from active ITP patients and ...
17
Local Expression of T Cell Subsets in Sensitized and Unsensitized Experimental Cystic Echinococcosis.
... of T cell subsets, T-helper 1 (Th1), T-helper 2(Th2), T regulatory ...and T cytotoxic (CD8) in sensitized (immunized using hydatid cyst fluid antigen) and unsensitized ...
11
Follicular helper T cell signature in type 1 diabetes
... obtain sufficient cells of each type, cells from 14 mice were pooled to generate each sample. Mice were randomly assigned into groups. Three to six replicates were collected per experimental group (each replicate ...
13
Effective antigen presentation to helper T cells by human eosinophils
... (p<0.001) increases in proliferation were observed when eosinophils had been pulsed by pre-incubation with the allergens HDM (Figure 1A) or TG (Figure 1B) at final concentrations of 1000, 1500 or 2500 IU/ml, compared ...
20
A detailed phenotypic analysis of immune cell populations in the bronchoalveolar lavage fluid of atopic asthmatics after segmental allergen challenge
... Although inflammation is critical to the pathogenesis of asthma, the exact cell types present in the lung and their differentiation state remain not well defined. In this report, we characterized the immune cell ...
8