T helper type 1, Th1
Multiple myeloma presenting as cutaneous leukocytoclastic vasculitis and eosinophilia disclosing a T helper type 1/T helper type 2 imbalance: a case report
... chain type, stage IIIA according to the Durie-Salmon system and stage II according to the International Sta- ging ...days 1, 4, 8, and 11; lenalidomide, 15 mg/day, days 1–21, and dexamethasone 20 ...
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In vitro Effects of Propranolol on T Helper Type 1 Cytokine Profile in Human
... In our study, propranolol reduced IFN-γ and IL-2 (Th1 cytokines) production. As Th1 cells have essential anti-tumor properties, 29 we might conclude that propranolol decreases anti-cancer immune responses. ...
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Plasma levels of monokine induced by interferon-gamma/chemokine (C-X-X motif) ligand 9, thymus and activation-regulated chemokine/chemokine (C-C motif) ligand 17 in children with Kawasaki disease
... (ESR). T cells activation has been reported to be participated in the immunological pathogenesis [3, 4], and some pro- inflammatory cytokines of T cells, such as interleukin-4 (IL-4), interferon-gamma ...
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Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer
... differentiation; Th1: type 1 T helper; PD‑L1: programmed cell death ligand‑1; PD‑1: programmed cell death protein‑1; TIL: tumor infiltrating lymphocyte; TIM: ...
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Determinant in Human Immunodeficiency Virus Type 1 for Efficient Replication under Cytokine-Induced CD4+ T-Helper 1 (Th1)- and Th2-Type Conditions
... IL-12-induced Th1-type culture, in contrast to NCN-SM, which could not efficiently ...duced Th1-type culture indicated that the V3 loop sequence of M-tropic HIV-1 may be necessary for ...
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Distinct gene expression profiles of human type 1 and type 2 T helper cells
... the Th1 cells the STAT4 is strongly ...the type I interferon receptors. Functional receptors for FGF in some human T cells have been reported by Zhao et ...in Th1 cells was ...of T ...
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Follicular helper T cell signature in type 1 diabetes
... the type of immune response that underlies autoim- mune tissue destruction is a critical step in designing appropri- ate immunomodulatory ...of type 1 diabetes (T1D), current dogma holds that ...
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Local Expression of T Cell Subsets in Sensitized and Unsensitized Experimental Cystic Echinococcosis.
... promoting Th1 cell differentiation (Uemura et ...regulatory T cells (Babu et al. 2005). In addition to cytotoxic T cell which is known as cytotoxic T lymphocyte, cytolytic T cell, CD8+ ...
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T Helper 22 Pathway Evaluation in Type 1 Diabetes and Its Complications
... but T-cells appear to play a pivotal role in the destruction process of the insulin-producing beta cells and the potential contributions of T helper (Th1/Th2) subsets in the disease process ...
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Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN gamma secreting TH1 cells in humans
... CD45RA(neg)/R0(pos) T cells. Notably, within the CD45RA(pos) subset, T cells with phenotypic evidence of prior activation, ...IL-4-producing T helper 2 (TH2)-type cells in the anti- CD4 ...
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Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome
... predominant type (C-IBS) or diarrhea-predominant type (D-IBS) according to the Roman III diagnostic criteria [7] were recruited for this study, including 20 PI-IBS patients with a history of acute enteritis ...
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Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load
... Immunophenotyping. For surface phenotyping, frozen peripheral blood mononuclear cells (PBMCs) were thawed, rested, and stained using a LIVE/DEAD Aqua dead cell staining kit (Thermo Fisher Scientific, Waltham MA, USA) per ...
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The pro-inflammatory potential of T cells in juvenile-onset systemic lupus erythematosus
... + T cells are known to regulate B cell autoantibody production through provision of co- stimulatory signals and cytokines ...individual T cell subsets in JSLE whilst central to dis- ease progression remains ...
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<em>Chlamydia trachomatis</em> recombinant MOMP encapsulated in PLGA nanoparticles triggers primarily T helper 1 cellular and antibody immune responses in mice: a desirable candidate nanovaccine
... Despite decades of effort in development of a C. tracho- matis vaccine, there is still no effective vaccine against this pathogen. To our knowledge, our study is the first to docu- ment encapsulation of full-length rMOMP ...
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Co Immunization of Plasmid DNA Encoding IL 12 and IL 18 with Bacillus Calmette Guérin Vaccine against Progressive Tuberculosis
... of IL-12 DNA vaccine constructs with the BCG vaccine in- duced more protective efficacy than the BCG vaccine at later stage of infection, and this vaccine efficiently inhibited the growth of M. tuberculosis in the ...
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Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in Helicobacter-infected BALB/c mice
... IFN-γ is known to play a role in mucosal antibody responses and to promote B cell isotype switching [31– 34]. IFN-γ deficiency in BALB/c mice, however, had no effect on total IgA and IgG levels in gastric juices (Fig. ...
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HIV integrase and the swan song of the CD4 T cells?
... Considering NHP models, a simple question must be asked –WHY do these viruses, albeit “cytolytic” after in vitro stimulation, not cause in their hosts a very rapid depletion of CD4 T lymphocytes, in all models of ...
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The role of IFN gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity
... the Th1-vs-Th2 dichotomy provided the paradigm according to which cell-mediated autoimmune diseases engage Th1 cells and their respective cytokines, while humorally mediated autoimmune diseases engage Th2 ...
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Abnormal T regulatory cells (Tregs: FOXP3+, CTLA 4+), myeloid derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC
... + T cells were isolated from BMCs obtained from 30 women with LLABCs and 8 HFDs using micro beads and LS filtration columns placed in the magnetic field of a MACS separator (Miltenyi ...+ T cells in TCM ...
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Relevance of tumor-infiltrating lymphocytes in breast cancer
... or HMGB1 (TLR4) leads to enhanced production of IL-1β, and consequently activation of both innate and adaptive immune responses [23]. Interestingly, the observation of enhanced antitumor immunity following treatment ...
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