T helper Type 2
An IL 13 inhibitor blocks the development of hepatic fibrosis during a T helper type 2–dominated inflammatory response
... fibrosis. T-helper type 2 (Th2) cytokines dominate the immune response in mice infected with Schistosoma man- soni, yet the specific contributions of IL-13 and IL-4 to the development of ...
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Multiple myeloma presenting as cutaneous leukocytoclastic vasculitis and eosinophilia disclosing a T helper type 1/T helper type 2 imbalance: a case report
... chain type) with leukocytoclastic vasculitis and ...a T helper type 1/T helper type 2 imbalance and T regulatory cells, and was successfully treated with ...
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Neither T-helper type 2 nor Foxp3+regulatory T cells are necessary for therapeutic benefit of atorvastatin in treatment of central nervous system autoimmunity
... naïve T cells isolated from 4-GET mice differentiate into eGFP + T cells in vitro (Additional file 1: Figure ...naïve T cells upon αCD3/αCD28 ...naïve T cells, indicating that Th2 ...
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SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses
... we observed consistent blunting of IL-6–induced STAT3 phosphorylation (Fig. 4 E and Fig. S3 C). Interestingly, SOCS2 expression was induced after IL-6 and TGF- stimulation (Fig. S3 E) and, when stimulated under Th17 ...
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Plasma levels of monokine induced by interferon-gamma/chemokine (C-X-X motif) ligand 9, thymus and activation-regulated chemokine/chemokine (C-C motif) ligand 17 in children with Kawasaki disease
... (ESR). T cells activation has been reported to be participated in the immunological pathogenesis [3, 4], and some pro- inflammatory cytokines of T cells, such as interleukin-4 (IL-4), interferon-gamma ...
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Effect of <em>Ascaris lumbricoides</em> infection on T helper cell type 2 in rural Egyptian children
... significant (P,0.01). In addition, the mean concentration of IL-5 for those with mild infection was 380.95 ± 9.8 pg/mL, and this was statistically different from those with moderate infection of 406.54 ± 29.0 pg/mL ...
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T Helper 1/T Helper 2 Cytokine Imbalance in Respiratory Syncytial Virus Infection Is Associated With Increased Endogenous Plasma Cortisol
... plasma cortisol was observed in infants with mild as well as in those with severe disease, the imbalance of the Th1/Th2 response, with a deficient type 1 response, was present only in those cases with severe ...
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Epidermal Growth Factor Receptor Expression Licenses Type 2 Helper T Cells to Function in a T Cell Receptor Independent Fashion
... induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resis- tance in a T cell receptor (TCR)-independent ...on T ...
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Expression of intelectin-1 in bronchial epithelial cells of asthma is correlated with T-helper 2 (Type-2) related parameters and its function
... attracts T-helper (Th)1 cells [20] and strongly induced by ...produce type I IFN and CXCL10 after stimulation with double stranded RNA [22], perhaps contributing to the pathogenesis of viral ...
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T-helper-1, T-helper-17, T-regulatory lymphocytes in hypertensive patients with diabetes mellitus type 2 or impaired glucose tolerance: association with clinical and metabolic parameters in a case control study
... mellitus type 2 (DM2) and impaired glucose tolerance (IGT), but immune regulatory mechanisms involved in these processes are studied ...of T-helper-1 (Th1), Th17 and T-regulatory ...
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Egyptian Study of Post-transplant sCD30 as a Predictor of Kidney Graft Outcome
... Abstract Background: Previous studies revealed the potential value of the soluble CD30 level (sCD30) a marker for T helper 2-type cytokine-producing Tcells as biomarker for the risk of acute ...
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The Role of Eosinophils in the Regulation of CD4+ T helper 2 Regulated Inflammation
... and T lymphocytes, in the same manner as T cell hybridomas have been used by others (Del Pozo et ...wild type mice following sensitisation and subsequent airways challenge with OVA (Figure ...wild ...
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In vitro Effects of Propranolol on T Helper Type 1 Cytokine Profile in Human
... In the present study we showed that propranolol inhibited the PHA-induced secretion of IL-2 and IFN- γ by human leukemic T (Molt-4 and Jurkat) cells. Decrease of IFN-γ by propranolol in our findings is ...
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T Helper 22 Pathway Evaluation in Type 1 Diabetes and Its Complications
... The results were expressed as mean±SD. The normality of the quantitative variables was confirmed by Kolmogorov-Smirnov test. The groups were compared by chi square test for gender of participants and independent ...
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Interleukin-17 and type 17 helper T cells in cancer management and research
... Several protocols that could affect the Th17 polarization are already in place for the treatment of inflammatory disorders, like mAbs against IL-23 and IL-6R, or IL-1R antagonists and small-molecule inhibitors that ...
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T helper cell mediated-tolerance towards fetal allograft in successful pregnancy
... in rejecting allografts [13], indicating that some Th1- dependent effector mechanisms play a central role in acute allograft rejection of transplanted tissues [14]. On the other hand, the production of the ...
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Purified protein derivative of Mycobacterium tuberculosis and excretory secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
... that T cells with stable Th1 or Th2 functional pattern exist not only in mice but also in humans and suggest that in the course of natural immunization certain infectious agents preferentially expand T cell ...
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Distinct gene expression profiles of human type 1 and type 2 T helper cells
... the type I interferon receptors. Functional receptors for FGF in some human T cells have been reported by Zhao et ...of T helper cell develop- ment, depending on the state of differentiation ...
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Decoy receptors in the regulation of T Helper cell type 2 response
... IL-13R 2 appears to have evolved to specifically inhibit the IL-13–mediated func- tions, though in the present schistosome infection study only an affect on fibrosis has been ...IL-13R 2-Fc fusion protein ...
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Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN gamma secreting TH1 cells in humans
... ducing T helper 2 (TH2)-type cells in the anti-CD4 treated group was observed, numbers of IFN- g –producing T helper 1 (TH1)-type cells remained stable, resulting in a ...
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