T helper type 2 (Th2) cell
Simultaneous disruption of Interleukin (IL) 4 and IL 13 defines individual roles in T Helper cell Type 2 mediated responses
... in T helper type 2 (Th2) cell ...a Th2-like response, we have compared the responses of the double-deficient mice with those generated by wild-type, IL-4–deficient, ...
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Multiple myeloma presenting as cutaneous leukocytoclastic vasculitis and eosinophilia disclosing a T helper type 1/T helper type 2 imbalance: a case report
... myeloma cell growth by the blockade of NF-κB and down-regulation of cytokines, such as IL-6 ...CD8 T cells, and repair T-helper sub- sets with the Th1/Th2 response ...of Th2 ...
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SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses
... Th cell subsets (Murphy and Stockinger, 2010). T cell plasticity and lineage fate are also governed by the cytokines they encounter after antigen recog- ...+ T cell differentiation ...
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Cell fate decision: T helper 1 and 2 subsets in immune responses
... [100]. T cells from mice deficient in the p38 upstream kinase MKK3 have an intrin- sic defect to produce normal levels of IFN- γ , even when provided with APCs from a wild-type B6 mouse ...
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Decoy receptors in the regulation of T Helper cell type 2 response
... the Th2 cytokine receptors have been identified in serum or urine, but their functional importance remains ...IL-13R 2 appears to have evolved to specifically inhibit the IL-13–mediated func- tions, though ...
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Determinant in Human Immunodeficiency Virus Type 1 for Efficient Replication under Cytokine-Induced CD4+ T-Helper 1 (Th1)- and Th2-Type Conditions
... in cell proliferation among infected cells were not observed during these experiments, it is unlikely that the low level of HIV-1 replication with NL4-3, CNC-DX, and NCN-SM infection is due to its cytotoxic effect ...
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Distinct gene expression profiles of human type 1 and type 2 T helper cells
... human T cells has been reported [1,31]. The expression profile of the type 2 cells has somewhat fewer inflammatory mediators than Th1 ...in Th2 cells than in Th1 ...classical Th2 ...
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Follicular helper T cell signature in type 1 diabetes
... the type of immune response that underlies autoim- mune tissue destruction is a critical step in designing appropri- ate immunomodulatory ...of type 1 diabetes (T1D), current dogma holds that Th1 cells ...
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Epidermal Growth Factor Receptor Expression Licenses Type 2 Helper T Cells to Function in a T Cell Receptor Independent Fashion
... that Th2 cells contribute to worm expulsion at the site of infection (Anthony et ...how Th2 cells are activated at the site of infection. A number of cell types, such as macrophages, endothelial ...
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Local Expression of T Cell Subsets in Sensitized and Unsensitized Experimental Cystic Echinococcosis.
... Th cell differentiation (Levy and Darnell, 2002; Zhu et ...Th1 cell differentiation (Uemura et ...of Th2 cells (Lundi et ...regulatory T cells (Babu et al. 2005). In addition to cytotoxic ...
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Effect of <em>Ascaris lumbricoides</em> infection on T helper cell type 2 in rural Egyptian children
... Th1 cells are known by their production of IL-2 and INF- γ . INF- γ stimulates resting macrophages and causing them to secrete an assortment of molecules, as TNF- α , reactive oxygen intermediates, and nitrous ...
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Th1/Th17 polarization persists following whole cell pertussis vaccination despite repeated acellular boosters
... function of childhood vaccination. In a first series of cross-sectional experiments, we examined whether the difference in polarization between aP and wP donors was still detected in adulthood. These donors were ...
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Alterations in cytotoxic and helper T cell function after infection of T cell clones with human T cell leukemia virus, type I
... this helper function became independent of DPw2-stimulation and persisted even when the cytotoxic activity was ...OKT4+ T cell clone thus could simultaneously manifest both cytotoxic and ...
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Cellular Immune Responses to Recombinant Mycobacterium bovis BCG Constructs Expressing Major Antigens of Region of Difference 1 of Mycobacterium tuberculosis
... of Th2 cy- tokine IL-5, but they could induce secretion of detectable levels of the anti-inflammatory cytokine IL-10, which was secreted in re- sponse to the peptide pools of PE35, CFP10, and ESAT6, from ...
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Original Article Transformations of peripheral T cell subset distributions in oral cancer patients and the effect of P53 gene therapy in a short time
... and T cell function due to the lack of a costimulatory signal ...dendritic cell maturation and antigen-presenting ability, as well as directly inhibit T cell proliferation and function ...
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Transcriptional Regulation of T Helper 17 Cell Differentiation
... γ t , ROR α is induced by TGF β plus IL-6 in a STAT3-dependent manner, and promotes Th17 cell dif- ferentiation through direct activation of IL-17 gene trans- ...γ t and RORα ...
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IL 10 inhibits metalloproteinase and stimulates TIMP 1 production in human mononuclear phagocytes
... stimulation in the biosynthesis of TIMP-1. TIMP-2 production was not affected. IL-10 regulated the expression of 92-kD gelatinase and TIMP-1 at the pretranslational level. Furthermore, IL-10 regulation was ...
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Cell-Mediated Immune Response to Human Papillomavirus Infection
... The most persuasive evidence for the association between cellular immune defects and HPV infection and related mor- bidities comes from persons with HIV infection. Such individ- uals show increased prevalence of ...
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Relevance of tumor-infiltrating lymphocytes in breast cancer
... The success of checkpoint inhibitors is highly dependent on the extent of a pre-existing immune response against the tumor, and the ability of immune-targeted therapies to re-stimulate/activate immune subsets. Because ...
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Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome
... or biochemical abnormalities, it has been viewed as a somatic manifestation of psychological stress. IBS is associated with abnormal intestinal motion and sensa- tions, intestinal infection, hypothalamic-pituitary-gut ...
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