T helper type 1 (Th1), T helper type 2 (Th2)
In vitro Effects of Propranolol on T Helper Type 1 Cytokine Profile in Human
... Introduction: Cytokines are a large group of proteins play a key role in inflammation. Down-regulation of pro-inflammatory cytokines has beneficial effect on heart function. Propranolol, as a non selective beta- ...
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Multiple myeloma presenting as cutaneous leukocytoclastic vasculitis and eosinophilia disclosing a T helper type 1/T helper type 2 imbalance: a case report
... LV is a systemic inflammatory disorder mostly involv- ing small vessels and is characterized by: segmental, angiocentric, neutrophilic inflammation; endothelial cell damage; and fibrinoid necrosis [1]. In MM, LV ...
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Plasma levels of monokine induced by interferon-gamma/chemokine (C-X-X motif) ligand 9, thymus and activation-regulated chemokine/chemokine (C-C motif) ligand 17 in children with Kawasaki disease
... (ESR). T cells activation has been reported to be participated in the immunological pathogenesis [3, 4], and some pro- inflammatory cytokines of T cells, such as interleukin-4 (IL-4), interferon-gamma ...
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Determinant in Human Immunodeficiency Virus Type 1 for Efficient Replication under Cytokine-Induced CD4+ T-Helper 1 (Th1)- and Th2-Type Conditions
... induced Th1- and IL-4-induced Th2-type culture cells before HIV-1 infection were compared by using a CCR5- or CXCR4- specific MAb and FACS ...IL-12-induced Th1-type culture cells ...
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T-helper-1, T-helper-17, T-regulatory lymphocytes in hypertensive patients with diabetes mellitus type 2 or impaired glucose tolerance: association with clinical and metabolic parameters in a case control study
... and Th1-lymphocytes after PBMC activa- tion, as well as reduced ratios Treg/Th17 and Treg/Th1 appeared to be the most important parameters in hyper- tensive DM2 ...
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Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome
... predominant type (C-IBS) or diarrhea-predominant type (D-IBS) according to the Roman III diagnostic criteria [7] were recruited for this study, including 20 PI-IBS patients with a history of acute enteritis ...
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Follicular helper T cell signature in type 1 diabetes
... that T cells responding to pancreas-derived self antigen upregulate this activation marker ...conventional T cells responding to tissue- derived self antigen were archetypal Tfh cell genes (Table 1 ...
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Purified protein derivative of Mycobacterium tuberculosis and excretory secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
... that T cells with stable Th1 or Th2 functional pattern exist not only in mice but also in humans and suggest that in the course of natural immunization certain infectious agents preferentially expand ...
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Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer
... differentiation; Th1: type 1 T helper; PD‑L1: programmed cell death ligand‑1; PD‑1: programmed cell death protein‑1; TIL: tumor infiltrating lymphocyte; TIM: ...
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Distinct gene expression profiles of human type 1 and type 2 T helper cells
... in Th2 cells compared to Th1 ...for Th2 cells, the IL-12 is neutralized in the medium with an antibody, whereas in the Th1 cells the STAT4 is strongly ...the type I interferon ...
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Decoy receptors in the regulation of T Helper cell type 2 response
... (Fig. 1). Two IL-13 binding chains have been identi- fied, IL-13R 1 and IL-13R 2, and these are members of the class I cytokine receptor ...IL-13R 1 chain has a longer intracellular domain ...
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SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses
... Experimental allergic airway inflammation. Mice were sensitized with OVA to induce allergic airway inflammation in a protocol optimized for mice on C57BL/6J strain background, as described previously (Fallon et al., ...
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T Helper 1/T Helper 2 Cytokine Imbalance in Respiratory Syncytial Virus Infection Is Associated With Increased Endogenous Plasma Cortisol
... CONCLUSIONS. In this study, we demonstrate that during the acute phase of RSV infection, there is an increase in the level of plasma cortisol that is parallel to the decrease in IL-12 and IFN- ␥ production. These ...
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T Helper 22 Pathway Evaluation in Type 1 Diabetes and Its Complications
... Fresh peripheral blood mononuclear cells (PBMCs) were separated from 2 ml of anti-coagulated blood by Ficoll-Hypaque (Lymphodex, innoTRAin, Germany) density gradient centrifugation. At least one million PBMCs were ...
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Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN gamma secreting TH1 cells in humans
... ducing T helper 2 (TH2)-type cells in the anti-CD4 treated group was observed, numbers of IFN- g –producing T helper 1 (TH1)-type cells remained ...
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Local Expression of T Cell Subsets in Sensitized and Unsensitized Experimental Cystic Echinococcosis.
... promoting Th1 cell differentiation (Uemura et ...of Th2 cells (Lundi et ...regulatory T cells (Babu et al. 2005). In addition to cytotoxic T cell which is known as cytotoxic T ...
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T-helper 1 versus T-helper 2 lymphocyte immunodysregulation is the central factor in genesis of Burkitt lymphoma: hypothesis
... Malaria and malnutrition, both very common in Equato- rial Africa, are thought to play part in the immunological events leading to lymphomagenesis [10-12]. Specifically, Malaria is known to alter cytokine production ...
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Relevance of tumor-infiltrating lymphocytes in breast cancer
... TNBC and HER2-positive breast cancers, although the reasons for this are not fully understood [39, 64–66]. The studies indicating a positive relationship between TILs and responses to NAC are summarized in Table ...
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Decreased T helper 17 cells in tuberculosis is associated with increased percentages of programmed death ligand 1, T helper 2 and regulatory T cells
... Peripheral blood from the enrolled subjects was sam- pled into heparin-containing tubes. Mononuclear cells were immediately isolated using Ficoll-Paque PLUS (GE Healthcare Life Sciences, Sweden), and were then suspended ...
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Th1/Th17 polarization persists following whole cell pertussis vaccination despite repeated acellular boosters
... Our results demonstrate that priming in the first few months after birth with the aP or wP vaccines induces different T cell pheno- types. Ex vivo analysis of pertussis responses revealed that, while original wP ...
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