T-Lymphocyte Epitopes
Rational Design of a Multiepitope Vaccine Encoding T-Lymphocyte Epitopes for Treatment of Chronic Hepatitis B Virus Infections
... HLA-A02 epitopes, yet the HLA-B07 epitopes were minimally immunogenic after DNA injection in the HLA transgenic ...HLA-A02 epitopes (pol 562 and env 335) that could not be resolved by mass spectrom- ...
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HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load
... HLA-B57 epitopes has also been found to select for specific viral escape variants, leading to, at times, dramatic increases in viral loads (6, ...of epitopes, this could explain why both of these alleles ...
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Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection
... cytotoxic T lymphocyte (CTL) response could be responsible for viral persistence during chronic hepatitis B virus ...CTL epitopes in the hepatitis B virus in several HLA-A2-positive patients with ...
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DNA and Modified Vaccinia Virus Ankara Vaccines Encoding Multiple Cytotoxic and Helper T-Lymphocyte Epitopes of Human Immunodeficiency Virus Type 1 (HIV-1) Are Safe but Weakly Immunogenic in HIV-1-Uninfected, Vaccinia Virus-Naive Adults
... The eight-color ICS protocol was previously validated (36) for detec- tion of live gamma interferon (IFN- ␥ )- and interleukin-2 (IL-2)-secreting CD3 ⫹ CD8 ⫹ and CD3 ⫹ CD4 ⫹ HIV-1-specific T cells. In addition, ...
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Between-Host Evolution of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1: an Approach Based on Phylogenetically Independent Comparisons
... Experimental studies (1, 6, 14, 26) have established that natural selection driven by host CTL is a major factor in the diversification of SIV within an individual infected host, but it has been much more difficult to ...
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Multiple HLA A11-restricted cytotoxic T-lymphocyte epitopes of different immunogenicities in the Epstein-Barr virus-encoded nuclear antigen 4.
... A total of 26 All-restricted clones isolated from polyclonal cultures of donor 1 were tested for recognition of the five epitope regions within EBNA4 by using both the panel of recombina[r] ...
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Dissection of H-2Db-restricted cytotoxic T-lymphocyte epitopes on simian virus 40 T antigen by the use of synthetic peptides and H-2Dbm mutants.
... The inability of mutant class I antigens of bml3SV and bml4SV cells to present an endogenously processed T antigen to CTL clone Y-1 and that of bml4SV cells to present the T antigen to t[r] ...
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Human Immunodeficiency Virus Mutations during the First Month of Infection Are Preferentially Found in Known Cytotoxic T-Lymphocyte Epitopes
... CTL epitopes reported in the Los Alamos National Laboratory HIV immunology ...CTL epitopes. A virus sequencing and reported CTL epitopes database analysis therefore support a model where a ...
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HIV-1 Gag Cytotoxic T Lymphocyte Epitopes Vary in Presentation Kinetics Relative to HLA Class I Downregulation
... ⫹ T lymphocyte, with an eclipse period of approximately 1 to 2 days before the release of new virions (13, 26, ...into epitopes via the HLA-I ...
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Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection
... escaping epitopes could have been underestimated if subjects were screened after escape had ...both epitopes, the immunologically susceptible form (position 1 of KW9 and position 9 of QR9, corresponding to ...
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Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins
... + T cell epitopes have been ...CTL epitopes (EL) showed no response in another study [23], and also in this ...CTL epitopes of EBOV-NP using overlap- ping ...CTL epitopes in EBOV-NP ...
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Identification of CD8+ cytotoxic T lymphocyte epitopes from porcine reproductive and respiratory syndrome virus matrix protein in BALB/c mice
... + T cells producing IFN-g on days 3, 5 and 12 after boosting with rWR-PRRSV-M was determined using flow cytometric ...+ T lymphocytes were acquired per sample and the number of IFN-g-secretion CD3 ...
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Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.
... The observation that p53, which is immunologically self, may carry an immunogenic epitope was not a priori self-evident. True, in the absence of nonself proteins, class I molecules are loaded with self peptides (reviewed ...
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Definition of human immunodeficiency virus type 1 gp120 and gp41 cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I alleles in simian-human immunodeficiency virus-infected rhesus monkeys.
... cytotoxic T-lymphocyte (CTL) responses in vaccinated and virus-infected ...CTL epitopes in SHIV-infected rhesus monkeys and characterized the major histocompatibility complex (MHC) class I alleles ...
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The Use of Epstein-Barr Virus-Transformed B Lymphocyte Cell Lines in a Peptide-Reconstitution Assay: Identification of CEA-related HLA-A*0301-Restricted Potential Cytotoxic T-Lymphocyte Epitopes
... 8. Nijman HW, JGA, et al. Identi- fication of peptide sequences that trigger HLA A2.1 restricted cytotoxic T lymphocytes. Eur J Immunol 9. Zeh HJ, Leder GH, Lotze MT, et al. de- termination of peptide class I ...
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Definition of Five New Simian Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitopes and Their Restricting Major Histocompatibility Complex Class I Molecules: Evidence for an Influence on Disease Progression
... CTL epitopes (five from SIV and three from HIV Env), five of which are bound by the same molecule, Mamu- ...of epitopes and has relied predominantly on Mamu- A*01-positive ...CTL epitopes and four ...
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Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape
... of epitopes by high-avidity CTLs was observed in patients with chronic HIV infection ...some epitopes in vivo might be due to insufficient antiviral pressure ...CTL epitopes (22) have also been ...
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Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen.
... ovalbumin epitopes dissociate at different rates; similar amounts of class I com- plexes were stabilized on the surface of RMA/s cells following extended incubation in the presence of these peptides ...of ...
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Identification and Antigenicity of Broadly Cross-Reactive and Conserved Human Immunodeficiency Virus Type 1-Derived Helper T-Lymphocyte Epitopes
... helper T lymphocytes (HTL) play a key role in the immune control of HIV type 1 (HIV-1) infection, and as such are an important target of potential HIV-1 ...HTL epitopes in HIV-1 that might serve as vaccine ...
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High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control
... these epitopes may contribute dispro- portionately to the observed association between Gag-specific responses and relative HIV control, we assessed the functional avidities of these responses in ...B57-KF11 ...
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