Target antigen
Chromatin as a target antigen in human and murine lupus nephritis
... obvious target structures in nephritic kidneys – nucleosomes released from dead ...this target structure, the antibodies remain nonpathogenic epi- phenomena despite their diagnostic ...
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Isolation of the target antigen of human anti tubular basement membrane antibody associated interstitial nephritis
... reactivity. Neither pooled normal human sera nor sera from patients with a variety of renal lesions not associated with alpha TBM-Ab (including interstitial nephritis and antiglomerular basement membrane disease) were ...
6
A tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines
... to target ratios of 5:1 and above effectively eliminated leukemia cells in CTL assays, when the lower effector to target ratio of 1:1 was used, we could still harvest the surviving leukemia cells and ...
17
Emphasis on the Role of PF4 in the Incidence, Pathophysiology and Treatment of Heparin Induced Thrombocytopenia
... PF4 target antigen might support an adaptive immune response, whereas a more transient exposure might result in only T-cell independent antibody produc- tion with the absence of an immune memory ...
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Late-phase expression of a murine cytomegalovirus immediate-early antigen recognized by cytolytic T lymphocytes.
... First, presentation of IE target antigen is not correlated with intranuclear presence of the major IE protein, but rather with its synthesis, and second, infected fibroblasts are suscept[r] ...
5
Effector mechanisms in organ specific autoimmunity I Characterization of a CD8+ T cell line that mediates murine interstitial nephritis
... This target antigen-specific effector T cell line, M52, was derived from bulk populations of CD8+ T cells isolated from susceptible animals immunized to produce ...
10
Antibody-drug conjugates--an emerging class of cancer treatment.
... of antigen expression varies greatly and depends on other target antigen properties such as the internalisation rate and binding affinity, as well as other ADC characteristics, such as cytotoxic ...
6
Identification of a new glycoprotein of herpes simplex virus type 1 and genetic mapping of the gene that codes for it.
... Preliminary immunoprecipitation experiments indicated that the target antigen was a glycoprotein of about 59,000 molecular weight, and reaction of the antibody with intertypic recombinan[r] ...
9
Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges
... the target antigen, the modified T cells with the second or third generation CARs usually demonstrate sustained proliferation, enhanced production of cytokines and tumor lytic activity, and reduced ...
7
Engineering switchable and programmable universal CARs for CAR T therapy
... chimeric antigen receptor (CAR) has a fixed design, and one type of CAR T cells can only target one antigen ...the antigen recognition domain is split from the signaling domain of a ...
9
Dendritic Cell Migration Limits the Duration of CD8+ T-Cell Priming to Peripheral Viral Antigen
... little antigen initially could utilize the refractory period of DC migration to establish a low-level infection, preventing adequate priming of T CD8 ⫹ that can clear all infected ...
9
Redundancy and Plasticity of Neutralizing Antibody Responses Are Cornerstone Attributes of the Human Immune Response to the Smallpox Vaccine
... surface antigen target in a majority of vac- cinees as determined by microarray ELISA and anti-H3 IgG exhibited the best correlation with the neutralizing antibody titer, to test the prediction that anti-H3 ...
18
A quantitative method for measuring the transfection efficiency of CD19-directed chimeric antigen receptor in target cells
... mine the ratio of infected cells to total cells. In addition, an antibiotic-resistance gene used in a recombinant vector is another method of screening for infected cells or valid cells with removing the uninfected ...
6
Identification Of Protein Profile Of A. Fumigatus For Diagnostic Intrest From Clinical Isolates
... The incidence of Aspergillus invasive disease has extensively increased in the last two decades. Invasive aspergillosis is the common fungal pathogen detected in tertiary care hospitals [1]. Characterization of the ...
6
Ahn_unc_0153D_18919.pdf
... digitally imaged at 20X objective using the Aperio ScanScope XT (Leica). TMA slides were de-arrayed to visualize individual cores and each core was visually inspected. Folded tissues were excluded from the analysis using ...
199
Mapping of B-cell epitopes of the human hepatitis B virus X protein.
... The carboxy-terminal half of the HBx antigen was the most frequent target for anti-HBx antibodies in sera of patients with viral hepatitis and contained an immunodominant antigenic regio[r] ...
8
Fast DNA Serotyping of Escherichia coli by Use of an Oligonucleotide Microarray
... Eight target sequences (isla29-O145_11, sil-inv-O145_11, rfbU-O157_11, sil-inv-O157_11, sil1-O157_11, sil2-O157_11, fliC-H01_11, and fliC-H46_11) showed strong cross-reactions with about 20% of all ...seven ...
10
Development of an ELISA for sensitive and specific detection of IgA autoantibodies against BP180 in pemphigoid diseases
... major target of pemphigoid autoantibodies is the bullous pemphigoid antigen of 180 kDa (BP180), also referred to as collagen XVII, a hemidesmosomal trans- membrane protein with a type II orientation whose ...
10
Anti liver endoplasmic reticulum autoantibodies are directed against human cytochrome P 450IA2 A specific marker of dihydralazine induced hepatitis
... identified as cytochrome P-450IA2 (P-450IA2) by (a) comparison of immunoblotting patterns with anti-human P-450IA2 and anti-rat P-450IA2 and with five anti-LM sera, and (b) specific immunoinhibition of microsomal ...
8
Lipopolysaccharide as an Antigen Target for the Formulation of a Universal Vaccine against Escherichia coli O111 Strains
... an antigen target for immunotherapy or vaccination (2, 10, 11, 51, ...O antigen, were able to protect human pa- tients against death from bacteremia due to Gram-negative bacteria (58) and sepsis when ...
9