Target Organs
Equine Herpesvirus 1 Bridles T Lymphocytes To Reach Its Target Organs
... ABSTRACT Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. “Hijacked” ...
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Sex differences of inflammation in target organs, induced intraperitoneal injection of lipopolysaccharide, depend on its dose
... the target organs manifested as severe endotoxemia and sex differences of pathological changes in the lungs and liver were not ...the organs of the immune system in females and males, as well as the ...
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Sub-chronic inhalation of lead oxide nanoparticles revealed their broad distribution and tissue-specific subcellular localization in target organs
... The lung represents an organ with maximum exposure to PbO nanoparticles and susceptibility to any toxic effects. As macrophages have difficulties identifying such small par- ticles and carrying out phagocytosis, lung ...
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Target organs for lymphocystis disease virus replication in gilthead seabream (Sparus aurata)
... internal organs, such as intestine, liver, spleen, kidney and brain, from asymptomatic, diseased and recovered gilthead seabream ...the organs analysed, including necrotic changes in liver and kidney, ...
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Acquisition of viral DNA sequences in target organs of chickens infected with avian myeloblastosis virus.
... To determine whether the increase in AMV DNA content represented the acquisition of new complete DNA copies of the AMV genome or amplification of preexisting endogenous sequences, H-labe[r] ...
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Thioredoxin 1 confines T cell alloresponse and pathogenicity in graft versus host disease
... Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective therapeutic procedure to treat hematopoietic malignan- cy such as leukemia through donor lymphocyte–mediated antitu- mor response, known as the ...
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Gene expression studies of host response to Salmonid alphavirus subtype 3 experimental infections in Atlantic salmon
... in target organs [32] with reproducible ...primary target organs (pancreas and heart) and concomitantly, an assessment of virus replication levels in these organs; secondly, an ...
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Different approaches for objective scoring of experimental post-operative adhesions in the rat model—a description
... Measurement can be classified into different categories of scales [16]. Categorical scoring systems relate to unordered features of peritoneal adhesions. The central tendency of a sample of categorical measurements may ...
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Cytokine mediators of chronic graft versus host disease
... In the clinic, the nature of cells infiltrating target organs remains poorly defined, likely reflecting differences over time and within individual organs. Nevertheless, Th1/Tc1, Th17/Tc17, and RORγT ...
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Therapeutic arthropods and other, largely terrestrial, folk-medicinally important invertebrates: a comparative survey and review
... Traditional healing methods involving hundreds of insect and other invertebrate species are reviewed. Some of the uses are based on the tenet of “ similia similibus ” (let likes be cured by likes), but not all ...
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Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans
... the target organs, and the algorithm requires the net accumulated radioactivity in source or- gans as an input ...source organs was derived from PET measure- ments and the organ volumes of the ...
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Subchronic oral toxicity of silver nanoparticles
... the target organs for silver nano- particles were shown to be the liver in a 28-day oral toxicity study [9] and the liver and lungs in a 90-day inhalation study ...the target organ and the tissue ...
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Impacts of microcystin, a cyanobacterial toxin, on laboratory rodents in vivo
... DISCUSSION AND CONCLUSIONS MC-LR is the most common cyanotoxin known to be hepatotoxic in mammals; however, summarized data presented in Tab. I-III demonstrate besides its hepatotoxicity several further adverse ...
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Preparation and preclinical evaluation of a 68Ga-labelled c(RGDfK) conjugate comprising the bifunctional chelator NODIA-Me
... [ nat Ga]3 = 205.1 ± 1.4 nM, c(RGDfK) 2 = 159.5 ± 1.3 nM) as determined in competitive cell binding experiments in U-87 MG cell line. In small-animal PET imaging and ex vivo biodistribution studies, the radiotracer [ 68 ...
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Therapeutic use of a receptor mimic probiotic reduces intestinal Shiga toxin levels in a piglet model of hemolytic uremic syndrome
... The probiotic strain expressing globotetraose used in this study was designed specifically to bind and neutralize Stx2e, the toxic principal of piglet edema disease. This construct was effective at neutralizing 98.4% of ...
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Detection of Visna Maedi virus in mesenteric lymph nodes and in other lymphoid tissues of sheep three years after respiratory infection
... The finding of both the proviral DNA and the viral capsid antigen in the mesenteric lymph nodes of sheep three years after infection by the respira- tory route was unexpected. In only one case was a weak positivity in ...
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Analysis of apyrase 5' upstream region validates improved Anopheles gambiae transformation technique
... mosquito target organs (primarily midgut, hemocoel and salivary glands), mainly in the yellow fever vector Aedes aegypti and in the Asian malaria vector Anopheles stephensi ...
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Knowledge gaps in host-parasite interaction preclude accurate assessment of meat-borne exposure to Toxoplasma gondii
... gondii predilection tissue in infected animals and (ii) the number of cysts that may be detected in non-target organs and (iii) the actual presence of viable cysts in seropositive and[r] ...
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Regulation of the synthesis of nerve growth factor
... Regulation of NGF synthesis in peripheral target organs after nerve transections: the iris as a model svstem In a first approach to test whether the state of innervation Ebendal, Olson &[r] ...
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THE EFFECT OF USING PET CT FUSION ON TARGET VOLUME DELINEATION AND DOSE TO ORGANS AT RISK IN 3D RADIOTHERAPY PLANNING OF PATIENTS WITH NSSLC
... of target volume delineation based on CT scan alone, which will eventually affect target volume coverage, ...planning target volume (PTV), as well as dose to the surrounding normal tissues at ...
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